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公开(公告)号：EP2833889A4
公开(公告)日：2015-11-11
申请号：EP13773141
申请日：2013-04-04
发明人： SINGH RAJINDER , DUNCTON MATTHEW , ZHANG JING , ALVAREZ SALVADOR , TSO KIN , HOLLAND SACHA , YEN ROSE , KOLLURI RAO , HECKRODT THILO , CHEN YAN , MASUDA ESTEBAN , LI HUI , PAYAN DONALD G , KELLEY RYAN
IPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61P29/00
CPC分类号： C07D471/04 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5386 , A61K31/553 , C07D519/00 , C12N9/12 , C12Q1/485 , C12Y207/11013
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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2.发明公开METHODS FOR TREATING INFLAMMATORY DISORDERS USING 2,4-PYRIMIDINEDIAMINE COMPOUNDS 审中-公开方法炎性疾病的与2,4- PYRIMIDINDIAMINVERBINDUNGEN于治疗
公开(公告)号：EP2387402A4
公开(公告)日：2014-11-12
申请号：EP10732052
申请日：2010-01-13
发明人： LI HUI , MASUDA ESTEBAN , YUNG STEPHANIE , KINOSHITA TAISEI , DING RONGXIAN , SINGH RAJINDER , GURURAJA TARIKERE , PAYAN DONALD , TSO KIN
IPC分类号： A61K31/506 , A61K31/505 , A61P29/00
CPC分类号： A61K31/506
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公开(公告)号：EP2370415A4
公开(公告)日：2012-09-12
申请号：EP09835863
申请日：2009-12-23
发明人： BHAMIDIPATI SOMASEKHAR , LI HUI , SINGH RAJINDER , TAYLOR VANESSA , CLOUGH JEFFREY , MCMURTRIE DARREN
IPC分类号： A61K31/505 , A61P37/06 , C07D239/48
CPC分类号： C07D239/48
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4.发明公开2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATMENT OF INFLAMMATORY DISORDERS 有权2.4 PYRIMIDINDIAMINVERBINDUNGEN炎症性疾病的治疗
公开(公告)号：EP2387565A4
公开(公告)日：2012-07-11
申请号：EP10732053
申请日：2010-01-13
发明人： GURURAJA TARIKERE , PAYAN DONALD , TSO KIN , KINOSHITA TAISEI , DING RONGXIAN , SINGH RAJINDER , YUNG STEPHANIE , LI HUI , MASUDA ESTEBAN
IPC分类号： C07D239/32 , A61K31/495 , A61P29/00 , C07D239/30 , C07D403/12 , C07D451/04
CPC分类号： C07D451/04
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5.发明公开COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 有权ZUSAMMENSETZUNGEN UND VERFAHREN ZUR INHIBIERUNG DES JAK-PFADES
公开(公告)号：EP1904457A4
公开(公告)日：2010-06-02
申请号：EP06784727
申请日：2006-06-08
发明人： LI HUI , THOTA SAMBAIAH , CARROLL DAVID , ARGADE ANKUSH , TSO KIN , SRAN ARVINDER , CLOUGH JEFFREY , KEIM HOLGER , BHAMIDIPATI SOMASEKHAR , TAYLOR VANESSA , COOPER ROBIN , SINGH RAJINDER , WONG BRIAN
IPC分类号： C07D239/48 , A61K31/505 , A61P35/00 , A61P37/06 , A61P37/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/04
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
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公开(公告)号：EP3286181A1
公开(公告)日：2018-02-28
申请号：EP16719191
申请日：2016-04-22
发明人： KELLEY RYAN , LI HUI , HECKRODT THILO , CHEN YAN , MCMURTRIE DARREN , TSO KIN , TAYLOR VANESSA , SINGH RAJINDER , YEN ROSE , MAUNG JACK
IPC分类号： C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/426 , A61P9/00 , A61P35/00 , A61P43/00 , C07D405/04 , C07D413/04 , C07D417/04 , C07D417/14
CPC分类号： C07F9/65586 , C07D405/04 , C07D405/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D471/04
摘要： Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are methods of making and using the compounds and compositions. The disclosed compounds and/or compositions may be used to treat or prevent an IRAK-associated disease or condition.
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公开(公告)号：EP2382210A4
公开(公告)日：2012-06-20
申请号：EP09837134
申请日：2009-12-29
发明人： SINGH RAJINDER , ATUEGBU ANDY , RAMPHAL JOHN , LI HUI , GELMAN MARINA , CLOUGH JEFFREY , VALDEZ CARLOS , BHAMIDIPATI SOMASEKHAR , THOTA SAMBAIAH , MCMURTRIE DARREN
IPC分类号： C07D413/14 , A61K31/506 , A61P35/00 , C07D413/12 , C07D417/12 , C07D487/08 , C07D498/04
CPC分类号： A61K31/5383 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D487/08 , C07D498/04
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8.发明授权METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINEDIAMINE COMPOUNDS 有权方法用2,4嘧啶CONNECTIONS治疗或PRûVENTION自身免疫性疾病
公开(公告)号：EP1534286B1
公开(公告)日：2009-12-09
申请号：EP03784871
申请日：2003-07-29
发明人： SINGH RAJINDER , ARGADE ANKUSH , PAYAN DONALD G , CLOUGH JEFFREY , KEIM HOLGER , SYLVAIN CATHERINE , LI HUI , BHAMIDIPATI SOMASEKHAR
IPC分类号： A61K31/506 , A61K31/519 , A61P37/00
CPC分类号： A61K31/506 , A61K31/519 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04 , Y10S514/825 , Y10S514/903
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systematic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
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公开(公告)号：EP1471915A4
公开(公告)日：2006-02-15
申请号：EP03707654
申请日：2003-01-31
发明人： SINGH RAJINDER , ARGADE ANKUSH , PAYAN DONALD G , MOLINEAUX SUSAN , HOLLAND SACHA J , CLOUGH JEFFREY , KEIM HOLGER , BHAMIDIPATI SOMASEKHAR , SYLVAIN CATHERINE , LI HUI , ROSSI ALEXANDER B
IPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P1/00 , A61P11/06 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D239/28
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signalling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signalling cascades.
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