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    N-PHENYL ANTHRANILIC ACID DERIVATIVES AND USES THEREOF
    2.
    发明公开
    N-PHENYL ANTHRANILIC ACID DERIVATIVES AND USES THEREOF 有权
    N-苯基苯并噻吩酸衍生物及其用途

    公开(公告)号：EP2203411A2

    公开(公告)日：2010-07-07

    申请号：EP08808058.5

    申请日：2008-09-18

    申请人： Ramot at Tel-Aviv University Ltd.

    发明人： ATTALI, Bernard ,  PERETZ, Asher

    IPC分类号： C07C229/42 ,  C07C229/38 ,  C07C237/34 ,  C07C219/32 ,  A61P9/10 ,  A61P25/16 ,  A61P25/28 ,  A61K31/136

    CPC分类号： C07C237/20 ,  C07C229/42 ,  C07C229/58 ,  C07C233/54 ,  C07C237/32 ,  C07C291/02 ,  C07D207/40 ,  C07D213/80 ,  C07D303/16

    摘要： ABSTRACT Compounds that can be used as openers or blockers of voltage-dependent potassium channels, and which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing or enhancing cortical and/or peripheral neuron activity, compositions containing same and methods utilizing same are disclosed. Also disclosed are modulators of voltage-dependent potassium channels, which exhibit blocking of a TRPV1 channel, and hence are useful in the treatment of TRPV1-related conditions.

    摘要翻译： 摘要可用作电压依赖性钾通道的开放剂或阻断剂的化合物，其可用于通过调节钾离子通量通过电压依赖性钾通道调节中枢或周围神经系统疾病等病症和/或 公开了抑制或增强皮质和/或外周神经元活性，含有其的组合物和使用它们的方法。 还公开了电压依赖性钾通道的调节剂，其表现出阻断TRPV1通道，因此可用于治疗TRPV1相关病症。