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    LERCANIDIPINE SALTS
    1.
    发明公开
    LERCANIDIPINE SALTS 有权

    公开(公告)号：EP1799644A1

    公开(公告)日：2007-06-27

    申请号：EP05776228.8

    申请日：2005-08-22

    申请人： Recordati Ireland Limited ,  RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a.

    发明人： LEONARDI, Amedeo ,  MOTTA, Gianni ,  VON RAUMER, Markus

    IPC分类号： C07D211/90 ,  A61K31/4422 ,  A61P9/12

    CPC分类号： C07D211/90

    摘要： The invention relates to new addition salts comprising lercanidipine and an acid counterion selected from the group consisting of: (i) inorganic acids, (ii) sulphonic acids, (iii) monocarboxylic acids, (iv) dicarboxylic acids, (v) tricarboxylic acids, and (vi) aromatic sulphonimides, with the proviso that said acid counterion is not hydrochloric acid. In particular, both amorphous and crystalline salts of lercanidipine with benzenesulphonic and naphthalene- 1,5-disulphonic acids are disclosed, as are amorphous salts of lercanidipine with several other acid counterions.

    摘要翻译： （i）无机酸，（ii）磺酸，（iii）一元羧酸，（iv）二元羧酸，（v）三元羧酸， 和（vi）芳族磺酰亚胺，条件是所述酸抗衡离子不是盐酸。 具体而言，公开了苯基磺酸和萘-1,5-二磺酸的乐卡地平的无定形盐和结晶盐，以及具有几种其他酸抗衡离子的乐卡地平的无定形盐。