公开(公告)号：EP1560817A1

公开(公告)日：2005-08-10

申请号：EP03797788.1

申请日：2003-03-26

申请人： Reddy US Therapeutics, Inc.

发明人： TIMMER, Richard, T. ,  ALEXANDER, Christopher, W. ,  PILLARISETTI, Sivaram ,  SAXENA, Uday ,  YELESWARAPU, Koteswar RaoFlat no 21003 ,  PAL, Manojit ,  REDDY, Jangalgar Tirupathy ,  REDDY, Velagala Venkata Rama Murali Krishna ,  ALLURI, Sesha, Sridevi ,  KUMAR, Potlapally, Rajender ,  REDDY, Gaddam, Om, H.No.1, Golden Glean

IPC分类号： C07D251/18 ,  C07D251/70 ,  C07D401/04 ,  C07D407/04 ,  C07D409/04 ,  C07D413/10 ,  C07D417/04 ,  A61K31/53 ,  A61P35/00 ,  A61P19/02 ,  A61P17/06

CPC分类号： C07D413/04 ,  A61K31/53 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/65217 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：EP1796673A2

公开(公告)日：2007-06-20

申请号：EP05799686.0

申请日：2005-09-23

申请人： Reddy US Therapeutics, Inc. ,  Kalleda, Srinivas ,  Padakanti, Srinivas ,  Swamy, Nalivela, Kumara ,  Rao, Yeleswarapu Koteswar ,  Alexander, Christopher W. ,  Khanna, Ish Kumar ,  Iqbal, Javed ,  Pillarisetti, Sivaram ,  Pal, Manojit ,  Barange, Deepak

发明人： PAL, Manojit ,  KALLEDA, Srinivas ,  PADAKANTI, Srivinas ,  KUMAR SWAMY, Nalivela, Plor 191, J.P.N. ,  YELESWARAPU, Koteswar, Rao,Flat 202,Krishna Arcade ,  ALEXANDER, Christopher, W. ,  KHANNA, Ish, Kumar ,  IQBAL, Javed, Flat 101, Sri Krishna Residency ,  PILLARISETTI, Sivaram ,  BARANGE, Deepak, H.No.235, c/o A. Srinivas

IPC分类号： A61K31/506 ,  C07D403/04 ,  C07D239/46

CPC分类号： C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

公开(公告)号：EP1436266A2

公开(公告)日：2004-07-14

申请号：EP02799019.1

申请日：2002-09-23

申请人： Reddy US Therapeutics, Inc.

发明人： TIMMER, Richard, T. ,  ALEXANDER, Christopher, W. ,  PILLARISETTI, Sivaram ,  SAXENA, Uday ,  CAMPBELL, Karen, A.

IPC分类号： C07D251/44

CPC分类号： C07D401/12 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/70 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D453/02

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

摘要翻译： 本发明涉及包含治疗由炎症反应引起的病理生理状况的化合物的方法和组合物。 具体而言，本发明涉及抑制或阻断糖化蛋白质诱导内皮细胞中信号相关炎症反应的化合物。 本发明涉及抑制平滑肌增殖的化合物。 具体而言，本发明涉及通过调节HSPG例如Perlecan来抑制平滑肌细胞增殖的化合物。 本发明进一步涉及化合物用于治疗以平滑肌增殖为特征的血管阻塞性病症如再狭窄和动脉粥样硬化的用途。