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公开(公告)号：EP2300013B1
公开(公告)日：2017-09-06
申请号：EP09751617.3
申请日：2009-05-21
发明人： WANG, Yihan , HUANG, Wei-Sheng , LIU, Shuangying , SHAKESPEARE, William, C. , THOMAS, R., Mathew , QI, Jiwei , LI, Feng , ZHU, Xiaotian , KOHLMANN, Anna , DALGARNO, David, C. , ROMERO, Jan, Antoinette, C. , ZOU, Dong
IPC分类号： A61K31/505 , A61K31/513
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/587 , C07F9/650941 , C07F9/65122 , C07F9/65127 , C07F9/65216 , C07F9/65217 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
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公开(公告)号：EP0413613B1
公开(公告)日：1994-06-08
申请号：EP90309092.6
申请日：1990-08-20
IPC分类号： C08K5/5397 , C07F9/6521 , C08G79/04 , C08L101/00
CPC分类号： C08L23/02 , C07F9/65217 , C08G73/0246 , C08G73/0273 , C08G73/0638 , C08G79/04 , C08K5/5397 , C08L63/00 , C08L101/00 , C08L2666/22 , C08L2666/14
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3.发明公开N-phenylsulfonyl-N'-pyrimidinyl and triazinyl ureas containing phosporus 失效含有苯二酚的N-苯甲酰基-N'-吡啶二酮和含有磷酸盐的三联脲
公开(公告)号：EP0112803A3
公开(公告)日：1984-11-28
申请号：EP83810604
申请日：1983-12-19
申请人： CIBA-GEIGY AG
发明人： Maier, Ludwig, Dr. , Meyer, Willy , Oertle, Konrad, Dr. , Roloff, Achim, Dr. , Töpfl, Werner, Dr.
CPC分类号： C07D521/00 , A01N57/08 , C07F9/304 , C07F9/3229 , C07F9/3808 , C07F9/3834 , C07F9/4006 , C07F9/4015 , C07F9/4021 , C07F9/4056 , C07F9/5325 , C07F9/65127 , C07F9/65217
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公开(公告)号：EP2300013A4
公开(公告)日：2012-09-12
申请号：EP09751617
申请日：2009-05-21
申请人： ARIAD PHARMA INC
发明人： WANG YIHAN , HUANG WEI-SHENG , LIU SHUANGYING , SHAKESPEARE WILLIAM C , THOMAS R MATHEW , QI JIWEI , LI FENG , ZHU XIAOTIAN , KOHLMANN ANNA , DALGARNO DAVID C , ROMERO JAN ANTOINETTE C , ZOU DONG
IPC分类号： A61K31/505 , A61K31/513
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/587 , C07F9/650941 , C07F9/65122 , C07F9/65127 , C07F9/65216 , C07F9/65217 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
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公开(公告)号：EP1560817A1
公开(公告)日：2005-08-10
申请号：EP03797788.1
申请日：2003-03-26
发明人： TIMMER, Richard, T. , ALEXANDER, Christopher, W. , PILLARISETTI, Sivaram , SAXENA, Uday , YELESWARAPU, Koteswar RaoFlat no 21003 , PAL, Manojit , REDDY, Jangalgar Tirupathy , REDDY, Velagala Venkata Rama Murali Krishna , ALLURI, Sesha, Sridevi , KUMAR, Potlapally, Rajender , REDDY, Gaddam, Om, H.No.1, Golden Glean
IPC分类号： C07D251/18 , C07D251/70 , C07D401/04 , C07D407/04 , C07D409/04 , C07D413/10 , C07D417/04 , A61K31/53 , A61P35/00 , A61P19/02 , A61P17/06
CPC分类号： C07D413/04 , A61K31/53 , C07D251/30 , C07D251/44 , C07D251/46 , C07D251/48 , C07D251/50 , C07D251/52 , C07D251/66 , C07D251/70 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D453/02 , C07D487/04 , C07F9/65217 , C07F9/65583
摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
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公开(公告)号：EP0205348B1
公开(公告)日：1991-09-25
申请号：EP86304470.7
申请日：1986-06-11
发明人： Artz, Steven Powell
IPC分类号： C07D239/47 , C07D251/16 , C07D239/52 , C07F9/547 , C07D239/42 , C07D251/46 , C07D239/48 , C07D251/22 , C07D405/04 , C07D411/04 , C07D405/12
CPC分类号： C07D521/00 , A01N47/36 , A01N57/24 , C07F9/588 , C07F9/65127 , C07F9/65187 , C07F9/65217 , C07F9/6561
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公开(公告)号：EP0205348A3
公开(公告)日：1987-06-24
申请号：EP86304470
申请日：1986-06-11
发明人： Artz, Steven Powell
IPC分类号： C07D239/47 , C07D251/16 , C07D239/52 , C07F09/65 , C07D239/42 , C07D251/46 , C07D239/48 , C07D251/22 , C07D405/04 , C07D411/04 , C07D405/12
CPC分类号： C07D521/00 , A01N47/36 , A01N57/24 , C07F9/588 , C07F9/65127 , C07F9/65187 , C07F9/65217 , C07F9/6561
摘要： Sulfonylurea derivatives of the formula
wherein
E is CH 2 or a single bond; W is 0 or S; R is H or CH 3 ; R, is halogen, nitro or a specified organic group; R 2 is an organic substituent; A is a mono- or bicyclic heterocyclic group, e.g. pyrimidinyl or triazinyl; and their agriculturally suitable salts exhibit potent herbicidal activity. Some also show a plant growth regulant effect. The novel compounds may be made by a variety of routes, e.g. by reacting an appropriate benzenesulfonyl isocyanate or isothiocyanate with the appropriate heterocyclic amine.摘要翻译： 下式的磺酰脲衍生物：其中E是CH2或单键; W是0或S; R是H或CH 3; R 1是卤素，硝基或特定的有机基团; R2是有机取代基; A是单环或双环杂环基团，例如 嘧啶基或三嗪基; 并且它们的农业上合适的盐表现出有效的除草活性。 有些还显示出植物生长调节剂的作用。 新化合物可以通过多种途径制备，例如， 通过使合适的苯磺酰基异氰酸酯或异硫氰酸酯与合适的杂环胺反应。
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公开(公告)号：EP0149977A3
公开(公告)日：1985-08-28
申请号：EP84810648
申请日：1984-12-19
申请人： CIBA-GEIGY AG
CPC分类号： C07F9/65217 , A01N57/32
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公开(公告)号：EP3210609A1
公开(公告)日：2017-08-30
申请号：EP17162419.0
申请日：2009-05-21
发明人： WANG, Yihan , HUANG, Wei-Sheng , LIU, Shuangying , SHAKESPEARE, William, C. , THOMAS, R., Mathew , QI, Jiwei , LI, Feng , ZHU, Xiaotian , KOHLMANN, Anna , DALGARNO, David, C. , ROMERO, Jan, Antoinette, C. , ZOU, Dong
IPC分类号： A61K31/505 , A61K31/513
CPC分类号： C07F9/6533 , C07D239/48 , C07F9/587 , C07F9/650941 , C07F9/65122 , C07F9/65127 , C07F9/65216 , C07F9/65217 , C07F9/65218 , C07F9/65583 , C07F9/65586 , C07F9/6561 , C07F9/65616 , C07F9/65685 , C07F9/657172 , C07F9/65846
摘要： The invention features compounds of the general formula (VIa) in which the variable groups are as defined herein, and to their preparation and use.
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公开(公告)号：EP2890702B1
公开(公告)日：2016-08-24
申请号：EP13780050.4
申请日：2013-08-28
发明人： ZICH, Thomas , FREIDL, Fritz, Johann , MEHOFER, Bernadette , DÖRING, Manfred , CIESIELSKI, Michael , BURK, Bettina
CPC分类号： C09K21/12 , C07D251/66 , C07F9/44 , C07F9/4476 , C07F9/65217 , C07F9/657154
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