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公开(公告)号：EP2041177A2
公开(公告)日：2009-04-01
申请号：EP07777380.2
申请日：2007-06-01
发明人： STEVENS, Sean , HUANG, Tammy T. , MARTIN, Joel H. , FAIRHURST, Jeanette L. , RAFIQUE, Ashique , SMITH, Eric , POBURSKY, Kevin J. , PAPADOPOULOS, Nicholas J. , FANDL, James P. , CHEN, Gang , KAROW, Margaret
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hlL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. The antibody or antibody fragment binds hlL-6R with an affinity at least 2-fold higher relative to its binding to monkey IL-6R.
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公开(公告)号：EP3406634A1
公开(公告)日：2018-11-28
申请号：EP18179622.8
申请日：2014-01-31
发明人： DAVIS, Samuel , SMITH, Eric , PATEL, Supriya , RAFIQUE, Ashique
IPC分类号： C07K16/28
CPC分类号： C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/46 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/53 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94 , C12N15/85
摘要： Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided.
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公开(公告)号：EP2041177B1
公开(公告)日：2011-12-14
申请号：EP07777380.2
申请日：2007-06-01
发明人： STEVENS, Sean , HUANG, Tammy T. , MARTIN, Joel H. , FAIRHURST, Jeanette L. , RAFIQUE, Ashique , SMITH, Eric , POBURSKY, Kevin J. , PAPADOPOULOS, Nicholas J. , FANDL, James P. , CHEN, Gang , KAROW, Margaret
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hlL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. The antibody or antibody fragment binds hlL-6R with an affinity at least 2-fold higher relative to its binding to monkey IL-6R.
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公开(公告)号：EP4417624A2
公开(公告)日：2024-08-21
申请号：EP24172994.6
申请日：2014-01-31
发明人： DAVIS, Samuel , SMITH, Eric , PATEL, Supriya , RAFIQUE, Ashique
IPC分类号： C07K16/28
CPC分类号： C07K16/2887 , C07K2317/3120130101 , C07K16/46 , C07K2317/2420130101 , C07K2317/5220130101 , C07K2317/7120130101 , C07K2317/73220130101 , C07K2317/73420130101 , C07K2317/9420130101 , C07K16/2809 , A61P43/00
摘要： Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided.
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公开(公告)号：EP4263616A1
公开(公告)日：2023-10-25
申请号：EP21844504.7
申请日：2021-12-17
发明人： DUNN, Michael , MORTON, Lori , STAHL, Neil , HUANG, Tammy , CHATTERJEE, Ishita , KAMAT, Vishal , RAFIQUE, Ashique
IPC分类号： C07K16/42 , A61P9/12 , A61K31/165
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公开(公告)号：EP2951207A1
公开(公告)日：2015-12-09
申请号：EP14706169.1
申请日：2014-01-31
发明人： DAVIS, Samuel , SMITH, Eric , PATEL,Supriya , RAFIQUE, Ashique
IPC分类号： C07K16/28
CPC分类号： C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/46 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/53 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94 , C12N15/85
摘要： Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided.
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公开(公告)号：EP3845563A3
公开(公告)日：2021-11-24
申请号：EP20207210.4
申请日：2007-10-02
发明人： STEVENS, Sean , HUANG, Tammy T , MARTIN, Joel H , FAIRHURST, Jeanette L , RAFIQUE, Ashique , TORRES, Marcela , POBURSKY, Kevin J , LEIDICH, Raymond W , WINDSOR, Joan A , MIKULKA, Warren R , AHRENS, Diana M , SHI, Ergang , PAPADOPOULOS, Nicholas J
IPC分类号： C07K16/28 , C12N15/13 , C12N5/12 , A61K39/395 , A61P37/00
摘要： An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (K D ) of less than 200 pM, as measured by surface plasmon resonance.
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公开(公告)号：EP3845563A2
公开(公告)日：2021-07-07
申请号：EP20207210.4
申请日：2007-10-02
发明人： STEVENS, Sean , HUANG, Tammy T , MARTIN, Joel H , FAIRHURST, Jeanette L , RAFIQUE, Ashique , TORRES, Marcela , POBURSKY, Kevin J , LEIDICH, Raymond W , WINDSOR, Joan A , MIKULKA, Warren R , AHRENS, Diana M , SHI, Ergang , PAPADOPOULOS, Nicholas J
IPC分类号： C07K16/28 , C12N15/13 , C12N5/12 , A61K39/395 , A61P37/00
摘要： An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (K D ) of less than 200 pM, as measured by surface plasmon resonance.
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公开(公告)号：EP3119811B1
公开(公告)日：2019-10-30
申请号：EP15715047.5
申请日：2015-03-20
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公开(公告)号：EP2951207B1
公开(公告)日：2018-08-08
申请号：EP14706169.1
申请日：2014-01-31
发明人： DAVIS, Samuel , SMITH, Eric , PATEL,Supriya , RAFIQUE, Ashique
CPC分类号： C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/46 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/53 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2317/94 , C12N15/85
摘要： Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided.
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