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公开(公告)号：EP3782639A1
公开(公告)日：2021-02-24
申请号：EP20197224.7
申请日：2016-12-08
发明人： BAIK, Andrew , CYGNAR, Katherine
摘要： Compositions and methods for treating lysosomal storage diseases are disclosed. Biotherapeutic complexes containing an internalization effector binding domain and a lysosomal replacement enzyme activity are disclosed. The biotherapeutic complexes are capable of entering cells, segregating to the lysosome, and delivering the replacement enzyme activity to the lysosome.
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公开(公告)号：EP4423119A1
公开(公告)日：2024-09-04
申请号：EP22818964.3
申请日：2022-10-27
发明人： SABIN, Leah , KYRATSOUS, Christos , PEFANIS, Evangelos , MOLLER-TANK, Sven , KATAKOWSKI, Joseph , BAIK, Andrew , CYGNAR, Katherine , SAMAI, Poulami , CALAFATI, Philip
IPC分类号： C07K14/745 , A61K38/36
CPC分类号： C07K14/745 , A61K38/00
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公开(公告)号：EP3386534A2
公开(公告)日：2018-10-17
申请号：EP16829343.9
申请日：2016-12-08
发明人： BAIK, Andrew , CYGNAR, Katherine
摘要： Compositions and methods for treating lysosomal storage diseases are disclosed. Biotherapeutic complexes containing an internalization effector binding domain and a lysosomal replacement enzyme activity are disclosed. The biotherapeutic complexes are capable of entering cells, segregating to the lysosome, and delivering the replacement enzyme activity to the lysosome.
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公开(公告)号：EP3793591A1
公开(公告)日：2021-03-24
申请号：EP19728288.2
申请日：2019-05-17
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公开(公告)号：EP3386534B1
公开(公告)日：2020-09-23
申请号：EP16829343.9
申请日：2016-12-08
发明人： BAIK, Andrew , CYGNAR, Katherine
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公开(公告)号：EP4074331A1
公开(公告)日：2022-10-19
申请号：EP22169278.3
申请日：2016-12-08
发明人： BAIK, Andrew , CYGNAR, Katherine
摘要： Compositions and methods for treating lysosomal storage diseases are disclosed. Biotherapeutic complexes containing an internalization effector binding domain and a lysosomal replacement enzyme activity are disclosed. The biotherapeutic complexes are capable of entering cells, segregating to the lysosome, and delivering the replacement enzyme activity to the lysosome.
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公开(公告)号：EP3448891A1
公开(公告)日：2019-03-06
申请号：EP17724667.5
申请日：2017-04-28
发明人： CYGNAR, Katherine , DELFINO, Frank
IPC分类号： C07K16/28
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公开(公告)号：EP3644722A1
公开(公告)日：2020-05-06
申请号：EP18749203.8
申请日：2018-06-27
发明人： MUJICA, Alexander O. , GUSAROVA, Viktoria , WANG, Cheng , KYRATSOUS, Christos , POTOCKY, Terra , CYGNAR, Katherine , MARTIN, Joel
IPC分类号： A01K67/027 , C07K14/705 , C12N15/86
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公开(公告)号：EP3635009A1
公开(公告)日：2020-04-15
申请号：EP18737065.5
申请日：2018-06-06
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公开(公告)号：EP3319994A1
公开(公告)日：2018-05-16
申请号：EP16741208.9
申请日：2016-07-06
发明人： ANDREEV, Julian , THAMBI, Nithya , DELFINO, Frank , MARTIN, Joel , THURSTON, Gavin , CYGNAR, Katherine , PAPADOPOULOS, Nicholas
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K47/6879 , A61K2039/507 , C07K14/4702 , C07K16/1203 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/2833 , C07K16/2866 , C07K16/2869 , C07K16/2896 , C07K16/32 , C07K2317/21 , C07K2317/31 , C07K2317/35 , C07K2317/76 , C07K2317/77 , C07K2319/00 , C07K2319/30 , C12N9/6454
摘要： The present invention provides multispecific antigen-binding molecules and uses thereof. The multispecific antigen-binding molecules comprise a first antigen-binding domain that specifically binds a target molecule, and a second antigen-binding domain that specifically binds an internalizing effector protein. The multispecific antigen-binding molecules of the present invention can, in some embodiments, be bispecific antibodies that are capable of binding both a target molecule and an internalizing effector protein. In certain embodiments of the invention, the simultaneous binding of the target molecule and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention results in the attenuation of the activity of the target molecule to a greater extent than the binding of the target molecule alone. In other embodiments of the invention, the target molecule is a tumor associated antigen, and the simultaneous binding of the tumor associated antigen and the internalizing effector protein by the multispecific antigen-binding molecule of the present invention causes or facilitates the targeted killing of tumor cells.
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