公开(公告)号：EP4269430A3

公开(公告)日：2024-01-10

申请号：EP23185050.4

申请日：2014-09-23

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MURPHY, Andrew J ,  THURSTON, Gavin ,  VARGHESE, Bindu ,  GURER, Cagen

IPC分类号： A01K67/027 ,  C12N15/90 ,  C07K14/705

摘要： Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.

公开(公告)号：EP4269430A2

公开(公告)日：2023-11-01

申请号：EP23185050.4

申请日：2014-09-23

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MURPHY, Andrew J ,  THURSTON, Gavin ,  VARGHESE, Bindu ,  GURER, Cagen

IPC分类号： C07K14/705

摘要： Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.

公开(公告)号：EP3434101A1

公开(公告)日：2019-01-30

申请号：EP18192264.2

申请日：2014-09-23

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MURPHY, Andrew J ,  THURSTON, Gavin ,  VARGHESE, Bindu ,  GURER, Cagen

IPC分类号： A01K67/027 ,  C12N15/90 ,  C07K14/705

摘要： Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.

公开(公告)号：EP3175706A1

公开(公告)日：2017-06-07

申请号：EP16206491.9

申请日：2014-09-23

申请人： Regeneron Pharmaceuticals, Inc.

发明人： MURPHY, Andrew J ,  THURSTON, Gavin ,  VARGHESE, Bindu ,  GURER, Cagen

IPC分类号： A01K67/027 ,  C12N15/90 ,  C07K14/705

CPC分类号： A01K67/0278 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/054 ,  A01K2217/072 ,  A01K2227/10 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/0331 ,  A01K2267/0381 ,  A01K2267/0387 ,  A61K49/0008 ,  C07K14/70503 ,  C07K14/70596 ,  C07K16/2809 ,  C07K16/2887 ,  C07K2317/31 ,  C07K2319/00 ,  C12N9/16 ,  C12N15/8509 ,  C12N15/89 ,  C12N15/902 ,  C12N15/907 ,  C12N2015/8518 ,  C12N2015/8527 ,  C12N2015/8572 ,  C12N2800/30 ,  C12Y301/03048 ,  G01N33/5011 ,  G01N33/5088 ,  G01N2500/04 ,  G01N2500/10

摘要： Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.

摘要翻译： 提供了转基因非人动物及其制备和使用方法和组合物，其中遗传修饰包括内源信号调节蛋白基因的人源化，特别是SIRP±基因的人源化。 描述了转基因小鼠，包括从内源SIRP±基因座表达人或人源化SIRP±蛋白的小鼠。