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公开(公告)号：EP3219312B1
公开(公告)日：2019-01-30
申请号：EP16203827.7
申请日：2005-03-30
申请人： Relypsa, Inc.
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公开(公告)号：EP1732523B1
公开(公告)日：2010-03-17
申请号：EP05732849.4
申请日：2005-03-30
申请人： Relypsa, Inc.
发明人： CHARMOT, Dominique , CHANG, Han, Ting , KLAERNER, Gerrit , COPE, Michael, James , LIU, Mingjun , LIU, Futian , MONG, Tony, Kwok-Kong
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
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公开(公告)号：EP1732524B1
公开(公告)日：2012-08-22
申请号：EP05747062.7
申请日：2005-03-30
申请人： Relypsa, Inc.
发明人： ALPERN, Robert , BUYSSE, Jerry, M. , CHANG, Han, Ting , CHARMOT, Dominique , COPE, Michael, James , FORDTRAN, John , KLAERNER, Gerrit
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising sodiumbinding polymers and pharmaceutical compositions thereof Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hypertension, chronic heart failure, end stage renal disease, liver cirrhosis, chronic renal insufficiency, fluid overload, or sodium overload.
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公开(公告)号：EP1732516B1
公开(公告)日：2009-12-30
申请号：EP05731099.7
申请日：2005-03-30
申请人： Relypsa, Inc.
发明人： CHARMOT, Dominique , FORDTRAN, John , CHANG, Han Ting , CONNOR, Eric , LIU, Mingjun , KLAERNER, Gerrit
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
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公开(公告)号：EP3219312A1
公开(公告)日：2017-09-20
申请号：EP16203827.7
申请日：2005-03-30
申请人： Relypsa, Inc.
发明人： LIU, Mingjun , CHARMOT, Dominique , COPE, Michael James , KLAERNER, Gerrit , MONG, Tony Kwok-Kong , LIU, Futian , CHANG, HanTing
CPC分类号： A61K31/78 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , A61K47/32 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
摘要： The present invention provides methods and compositions for the treatment of ion imbalances. In particular, the invention provides compositions comprising potassium binding polymers and pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are disclosed herein. Examples of these methods include the treatment of hyperkalemia, such as hyperkalemia caused by renal failure and/or the use of hyperkalemia causing drugs.
摘要翻译： 本发明提供了用于治疗离子失衡的方法和组合物。 特别地，本发明提供了包含钾结合聚合物及其药物组合物的组合物。 本文公开了聚合物和药物组合物用于治疗和/或预防有益效果的方法。 这些方法的例子包括治疗高钾血症，例如由肾衰竭引起的高钾血症和/或使用引起高血钾症的药物。
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公开(公告)号：EP2916851A2
公开(公告)日：2015-09-16
申请号：EP13779499.6
申请日：2013-10-08
申请人： Relypsa, Inc.
发明人： KLAERNER, Gerrit , BERMAN, Lance
IPC分类号： A61K31/78 , A61K31/7004 , A61K33/06 , A61P9/12 , A61P13/12
摘要： The present invention generally relates to methods of treating hypertension (HTN) in patients in need thereof wherein the patient optionally further suffers from chronic kidney disease (CKD) or Type II diabetes mellitus (T2DM). The invention also relates to methods of treating hyperkalemia in a patient in need thereof, wherein the patient suffers from CKD, T2DM or HTN and are optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The invention also relates to methods of treating kidney disease in a patient in need thereof, wherein the patient is optionally being treated with an effective amount of a renin-angiotensin-aldosterone system (RAAS) agent. The methods can comprise administering an effective amount of a potassium-binding agent to the patient to lower the patient's blood pressure and/or increase or stabilize the patient's kidney function.
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公开(公告)号：EP1732523B9
公开(公告)日：2010-06-02
申请号：EP05732849.4
申请日：2005-03-30
申请人： Relypsa, Inc.
发明人： CHARMOT, Dominique , CHANG, Han, Ting , KLAERNER, Gerrit , COPE, Michael, James , LIU, Mingjun , LIU, Futian , MONG, Tony, Kwok-Kong
CPC分类号： A61K31/78 , A61K9/14 , A61K9/1635 , A61K9/5026 , A61K9/5031 , A61K31/74 , A61K31/785 , A61K31/795 , A61K31/80 , A61K45/06 , C08F120/06 , C08F128/02 , Y10S514/838 , Y10S514/869 , Y10S514/87 , Y10S514/893
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