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1.发明公开VARIANTS OF HEPATITIS B VIRUS RESISTANT AGAINST SOME NUCLEOSIDE ANALOGUES, BUT SENSITIVE TO OTHERS, AND USES THEREOF 有权对一些核苷类似物敏感和耐药的核苷类似物乙型肝炎病毒的变种及其用途
公开(公告)号：EP1858915A1
公开(公告)日：2007-11-28
申请号：EP06723428.6
申请日：2006-03-14
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn , UNIVERSITÄT ZU KÖLN , Justus-Liebig-Universität Giessen
发明人： SCHILDGEN, Oliver , VOGEL, Martin , MATZ, Bertfried , ROCKSTROH, Juergen , KAISER, Rolf , DAEUMER, Martin , HELM, Martin , WEITNER, Lutwin , SCHEWE, Carl Knud , GERLICH, Wolfram
CPC分类号： C12N7/00 , C07K14/005 , C12N9/1276 , C12N2730/10121 , C12N2730/10122 , C12Q1/706 , C12Q2600/156 , G01N33/5761 , G01N2333/02
摘要： The present invention relates generally to the field of Hepatitis B variants exhibiting a reduced sensitivity to nucleoside analogues both in vivo and in vitro. More in particular, reverse transcriptase mutant rt 1233 V is provided. Present invention provides assays and methods for detecting such variant, which assays are useful in monitoring anti- viral therapeutic regimes and adjusting patient therapy. A diagnostic kit for detecting the presence of an HBV variant in a biological sample has also been described. Finally, the use of a farmaceutical composition to cure a subject suffering from a HBV infection, which HBV is resistant to lamuvidine and/or adefovir has been provided, which farmaceutical composition comprises the nucleoside analogue tenofovir.
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2.发明授权VARIANTS OF HEPATITIS B VIRUS RESISTANT AGAINST SOME NUCLEOSIDE ANALOGUES, BUT SENSITIVE TO OTHERS, AND USES THEREOF 有权对一些核苷类似物敏感和耐药的核苷类似物乙型肝炎病毒的变种及其用途
公开(公告)号：EP1858915B1
公开(公告)日：2014-04-02
申请号：EP06723428.6
申请日：2006-03-14
申请人： Rheinische Friedrich-Wilhelms-Universität Bonn , UNIVERSITÄT ZU KÖLN , Justus-Liebig-Universität Gießen
发明人： SCHILDGEN, Oliver , VOGEL, Martin , MATZ, Bertfried , ROCKSTROH, Juergen , KAISER, Rolf , DAEUMER, Martin , HELM, Martin , WEITNER, Lutwin , SCHEWE, Carl Knud , GERLICH, Wolfram
CPC分类号： C12N7/00 , C07K14/005 , C12N9/1276 , C12N2730/10121 , C12N2730/10122 , C12Q1/706 , C12Q2600/156 , G01N33/5761 , G01N2333/02
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