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公开(公告)号：EP1383916A2
公开(公告)日：2004-01-28
申请号：EP02723812.0
申请日：2002-04-08
发明人： CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , ZHAO, Haoran
CPC分类号： G01N33/573 , C07K14/4702 , G01N33/505 , G01N2333/9015 , G01N2500/04
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding TRAC1, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, RNAi, and ribozymes, that modulate lymphocyte activation via modulation of TRAC1; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
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公开(公告)号：EP1412745A2
公开(公告)日：2004-04-28
申请号：EP02723908.6
申请日：2002-04-18
发明人： CHU, Peter , JIANG, Yingping , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , SPENCER, Colin , ZHAO, Haoran
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K14/705 , G01N33/56972 , G01N2333/4703 , G01N2500/10
摘要： The present invention relates to regulation of lymphocyte activa tion and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
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