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1.发明授权DERIVATIVES OF N2-(3-PYRIDYL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES 有权用于治疗炎性，自身免疫疾病或增殖性病症Ñ2-（3-吡啶基或苯基）-N4-（哌啶-4-基）-2,4- PYRIMIDINEDIAMIN的合适的衍生物的治疗
公开(公告)号：EP2389373B1
公开(公告)日：2017-05-17
申请号：EP10701773.3
申请日：2010-01-21
发明人： SINGH, Rajinder , LI, Hui , ZHAO, Haoran , KOLLURI, Rao , TSO, Kin , RAMPHAL, John , GU, Shihai , VALDEZ, Carlos , ZHANG, Jing , STAUFFER, Emily , DUNCTON, Matthew , ALVAREZ, Salvador
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , A61K31/506 , A61P37/00
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
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2.发明公开DERIVATIVES OF N2-(3-PYRIDIL OR PHENYL)-N4-(4-PIPERIDYL)-2,4-PYRIMIDINEDIAMINE USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE OR PROLIFERATIVE DISEASES 有权用于治疗炎性，自身免疫疾病或增殖性病症Ñ2-（3-吡啶基或苯基）-N4-（哌啶-4-基）-2,4- PYRIMIDINEDIAMIN的合适的衍生物的治疗
公开(公告)号：EP2389373A1
公开(公告)日：2011-11-30
申请号：EP10701773.3
申请日：2010-01-21
发明人： SINGH, Rajinder , LI, Hui , ZHAO, Haoran , KOLLURI, Rao , TSO, Kin , RAMPHAL, John , GU, Shihai , VALDEZ, Carlos , ZHANG, Jing , STAUFFER, Emily , DUNCTON, Matthew , ALVAREZ, Salvador
IPC分类号： C07D401/12 , C07D401/14 , C07D413/12 , A61K31/506 , A61P37/00
CPC分类号： A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/55 , C07D401/12 , C07D401/14 , C07D413/12
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：EP1383916A2
公开(公告)日：2004-01-28
申请号：EP02723812.0
申请日：2002-04-08
发明人： CHU, Peter , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , ZHAO, Haoran
CPC分类号： G01N33/573 , C07K14/4702 , G01N33/505 , G01N2333/9015 , G01N2500/04
摘要： The present invention relates to regulation of lymphocyte activation. More particularly, the present invention is directed to nucleic acids encoding TRAC1, which is involved in modulation of lymphocyte activation. The invention further relates to methods for identifying and using agents, including small organic molecules, peptides, circular peptides, antibodies, lipids, antisense nucleic acids, RNAi, and ribozymes, that modulate lymphocyte activation via modulation of TRAC1; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression.
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公开(公告)号：EP2387572B1
公开(公告)日：2015-09-16
申请号：EP10732030.1
申请日：2010-01-13
发明人： ZHAO, Haoran , KOLLURI, Rao , VALDEZ, Carlos , TSO, Kin , SINGH, Rajinder , RAMPHAL, John
IPC分类号： C07D498/04 , C07D498/14 , A61K31/5383 , A61K31/535 , A61K31/506 , A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00
CPC分类号： C07D498/04 , A61K31/5383 , C07D498/14
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公开(公告)号：EP2387572A2
公开(公告)日：2011-11-23
申请号：EP10732030.1
申请日：2010-01-13
发明人： ZHAO, Haoran , KOLLURI, Rao , VALDEZ, Carlos , TSO, Kin , SINGH, Rajinder , RAMPHAL, John
IPC分类号： C07D413/14 , C07D413/12 , A61K31/506 , A61K31/407 , A61P3/00 , A61P9/00 , A61P29/00
CPC分类号： C07D498/04 , A61K31/5383 , C07D498/14
摘要： This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
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公开(公告)号：EP1412745A2
公开(公告)日：2004-04-28
申请号：EP02723908.6
申请日：2002-04-18
发明人： CHU, Peter , JIANG, Yingping , LI, Congfen , LIAO, X., Charlene , MASUDA, Esteban , PARDO, Jorge , SPENCER, Colin , ZHAO, Haoran
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： C07K14/705 , G01N33/56972 , G01N2333/4703 , G01N2500/10
摘要： The present invention relates to regulation of lymphocyte activa tion and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.
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7.发明授权2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES 有权2.4 PYRIMIDINDIAMINVERBINDUNGEN用于治疗或 预防自身免疫性疾病
公开(公告)号：EP1984357B1
公开(公告)日：2013-10-02
申请号：EP07778258.9
申请日：2007-02-16
发明人： CLOUGH, Jeffrey Wayne , BHAMIDIPATI, Somasekhar , SINGH, Rajinder , MASUDA, Esteban , ZHAO, Haoran
IPC分类号： C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , A61K31/506 , A61P29/00
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D498/04
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8.发明公开
公开(公告)号：EP2183225A1
公开(公告)日：2010-05-12
申请号：EP08782014.8
申请日：2008-07-17
发明人： SINGH, Rajinder , LI, Hui , ZHAO, Haoran , PAYAN, Donald G. , KOLLURI, Rao , TSO, Kin , RAMPHAL, John , GU, Shihai
IPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04 , A61K31/506 , A61P35/00
CPC分类号： C07D401/12 , C07D239/48 , C07D401/14 , C07D407/14 , C07D413/14 , C07D417/14 , C07D498/04
摘要： The invention encompasses Pyrimidine compounds and the compositions and methods using these compounds in the treatment of conditions in which inhibition of PKC and PKD is therapeutically useful.
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9.发明公开2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES 有权2.4 PYRIMIDINDIAMINVERBINDUNGEN用于治疗或 预防自身免疫性疾病
公开(公告)号：EP1984357A2
公开(公告)日：2008-10-29
申请号：EP07778258.9
申请日：2007-02-16
发明人： CLOUGH, Jeffrey Wayne , BHAMIDIPATI, Somasekhar , SINGH, Rajinder , MASUDA, Esteban , ZHAO, Haoran
IPC分类号： C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , A61K31/506 , A61P29/00
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D498/04
摘要： The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula (I), as well as related compositions and methods for treating a variety of autoimmune diseases.
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