公开(公告)号：EP1412745A2

公开(公告)日：2004-04-28

申请号：EP02723908.6

申请日：2002-04-18

申请人： Rigel Pharmaceuticals, Inc.

发明人： CHU, Peter ,  JIANG, Yingping ,  LI, Congfen ,  LIAO, X., Charlene ,  MASUDA, Esteban ,  PARDO, Jorge ,  SPENCER, Colin ,  ZHAO, Haoran

IPC分类号： G01N33/53 ,  G01N33/566

CPC分类号： C07K14/705 ,  G01N33/56972 ,  G01N2333/4703 ,  G01N2500/10

摘要： The present invention relates to regulation of lymphocyte activa tion and migration. More particularly, the present invention is directed to nucleic acids encoding EDG family GPCR proteins, e.g., EDG-1, 2, 3, 4, 5, 6, 7, or 8, which are involved in modulation of lymphocyte activation and migration. The invention further relates to methods for identifying and using agents, including small organic molecules, antibodies, peptides, cyclic peptides, nucleic acids, antisense nucleic acids, sphingolipid analogs, and ribozymes, that modulate lymphocyte activation or migration via modulation of EDG GPCRs and EDG related signal transduction; as well as to the use of expression profiles and compositions in diagnosis and therapy related to lymphocyte activation and suppression, and lymphocyte migration.