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公开(公告)号：EP3180328A1
公开(公告)日：2017-06-21
申请号：EP15753856.2
申请日：2015-08-14
发明人： CARROLL, David , SRAN, Arvinder , SINGH, Rajinder , HUANG, Jianing , TSVETKOV, Lyuben , ISSAKANI, Sarkiz , PAYAN, Donald , SHAW, Simon
IPC分类号： C07D401/14 , C07D215/40 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , A61K31/4706 , A61K31/496 , A61K31/5377 , A61P35/00
摘要： Disclosed are sulfonamidoquinoline compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein R1, R2, R3 and R4 are as described herein. In certain embodiments, a compound disclosed herein inhibits ubiquitination, and can be used to treat disease by blocking the degradation of tumor suppressors.
摘要翻译： 公开了磺酰胺基喹啉化合物，以及药物组合物和使用方法。 一个实施方案是具有结构和其药学上可接受的盐，前药和N-氧化物（及其溶剂化物和水合物）的化合物，其中R 1，R 2，R 3和R 4如本文所述。 在某些实施方案中，本文公开的化合物抑制泛素化，并且可用于通过阻断肿瘤抑制剂的降解来治疗疾病。
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2.发明授权COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY 有权ZUSAMMENSETZUNGEN UND VERFAHREN ZUR HEMMUNG DES JAK-PFADES
公开(公告)号：EP1991532B1
公开(公告)日：2017-01-11
申请号：EP07757438.2
申请日：2007-02-23
发明人： LI, Hui , ARGADE, Ankush , TSO, Kin , THOTA, Sambaiah , CARROLL, David , SRAN, Arvinder , COOPER, Robin , SINGH, Rajinder , BHAMIDIPATI, Somasekhar , MASUDA, Esteban , TAYLOR, Vanessa
IPC分类号： C07D239/48 , C07D417/12 , C07D401/12 , C07D403/12 , C07D409/12 , A61K31/505 , A61P37/06
CPC分类号： C07D239/50 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
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3.发明公开2,4 -PYRIMIDINEDIAMINE DERIVATIVES AS INHIBITORS OF JAK KINASES FOR THE TREATMENT OF AUTOIMMUNE DISEASES 有权2.4 PYRIDIMEDIAMON衍生物作为JAK激酶用于治疗自身免疫性疾病治疗的抑制剂
公开(公告)号：EP2089369A2
公开(公告)日：2009-08-19
申请号：EP07854253.7
申请日：2007-10-19
发明人： LI, Hui , ARGADE, Ankush , THOTA, Sambaiah , CARROLL, David , SRAN, Arvinder , COOPER, Robin , SINGH, Rajinder , TSO, Kin , BHAMIDIPATI, Somasekhar
IPC分类号： C07D239/48 , C07D403/12 , C07D498/04 , C07D401/12 , C07D417/12 , A61K31/505 , A61K31/506 , A61P37/06
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/052 , C07D498/04
摘要： The invention encompasses compounds having formula (I) and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases are therapeutically useful.
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4.发明授权2,4 -PYRIMIDINEDIAMINE DERIVATIVES AS INHIBITORS OF JAK KINASES FOR THE TREATMENT OF AUTOIMMUNE DISEASES 有权2.4 PYRIDIMEDIAMON衍生物作为JAK激酶用于治疗自身免疫性疾病治疗的抑制剂
公开(公告)号：EP2089369B1
公开(公告)日：2011-02-02
申请号：EP07854253.7
申请日：2007-10-19
发明人： LI, Hui , ARGADE, Ankush , THOTA, Sambaiah , CARROLL, David , SRAN, Arvinder , COOPER, Robin , SINGH, Rajinder , TSO, Kin , BHAMIDIPATI, Somasekhar
IPC分类号： C07D239/48 , C07D403/12 , C07D498/04 , C07D401/12 , C07D417/12 , A61K31/505 , A61K31/506 , A61P37/06
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/54 , A61K45/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/052 , C07D498/04
摘要： The invention encompasses compounds having formula (I) and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases are therapeutically useful.
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公开(公告)号：EP1991532A2
公开(公告)日：2008-11-19
申请号：EP07757438.2
申请日：2007-02-23
发明人： LI, Hui , ARGADE, Ankush , TSO, Kin , THOTA, Sambaiah , CARROLL, David , SRAN, Arvinder , COOPER, Robin , SINGH, Rajinder , BHAMIDIPATI, Somasekhar , MASUDA, Esteban , TAYLOR, Vanessa
IPC分类号： C07D239/48 , C07D417/12 , C07D401/12 , C07D403/12 , C07D409/12 , A61K31/505 , A61P37/06
CPC分类号： C07D239/50 , A61K31/505 , A61K31/506 , A61K45/06 , C07D239/48 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：EP3180328B1
公开(公告)日：2020-03-18
申请号：EP15753856.2
申请日：2015-08-14
发明人： CARROLL, David , SRAN, Arvinder , SINGH, Rajinder , HUANG, Jianing , TSVETKOV, Lyuben , ISSAKANI, Sarkiz , PAYAN, Donald , SHAW, Simon
IPC分类号： C07D401/14 , C07D215/40 , C07D401/04 , C07D401/12 , C07D405/04 , C07D409/04 , A61K31/4706 , A61K31/496 , A61K31/5377 , A61P35/00
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公开(公告)号：EP1904457B1
公开(公告)日：2017-09-06
申请号：EP06784727.7
申请日：2006-06-08
发明人： LI, Hui , THOTA, Sambaiah , CARROLL, David , ARGADE, Ankush , TSO, Kin , SRAN, Arvinder , CLOUGH, Jeffrey , KEIM, Holger , BHAMIDIPATI, Somasekhar , TAYLOR, Vanessa , COOPER, Robin , SINGH, Rajinder , WONG, Brian
IPC分类号： C07D239/48 , C07D413/12 , C07D498/04 , C07D405/12 , C07D403/12 , C07D417/14 , C07D401/12 , C07D417/12 , C07D401/14 , C07D413/14 , C07D409/12 , A61K31/505 , A61P37/06 , A61P37/08 , A61P35/00
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
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公开(公告)号：EP1904457A2
公开(公告)日：2008-04-02
申请号：EP06784727.7
申请日：2006-06-08
发明人： LI, Hui , THOTA, Sambaiah , CARROLL, David , ARGADE, Ankush , TSO, Kin , SRAN, Arvinder , CLOUGH, Jeffrey , KEIM, Holger , BHAMIDIPATI, Somasekhar , TAYLOR, Vanessa , COOPER, Robin , SINGH, Rajinder , WONG, Brian
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula (I-V) and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
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