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1.发明授权VARIANTS OF SOLUBLE PYRROLOQUINOLINE QUINONE-DEPENDENT GLUCOSE DEHYDROGENASE 有权可溶性PYRROLOQUINOLIN醌依赖性葡萄糖脱氢酶的变异研究
公开(公告)号：EP1332216B1
公开(公告)日：2011-08-17
申请号：EP01988775.1
申请日：2001-10-20
发明人： KRATZSCH, Peter , SCHMUCK, Rainer , BUNK, Daniela , SHAO, Zhixin , THYM, Detlef , KNAPPE, Wolfgang-Reinhold
CPC分类号： C12N9/0006
摘要： The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.
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2.发明公开A WALK-THROUGH TECHNIQUE FOR i IN VITRO /i RECOMBINATION OF POLYNUCLEOTIDE SEQUENCES 审中-公开A“步行通过”以科技求多核苷酸的体外重组
公开(公告)号：EP1404825A2
公开(公告)日：2004-04-07
申请号：EP02747439.4
申请日：2002-06-26
IPC分类号： C12N9/16
CPC分类号： C12N9/0034 , C12N9/16 , C12N15/102
摘要： A simple and efficient method for random in vitro mutagenesis and recombination of polynucleotide sequences based on walk-through with chain-elongating molecules and chain terminating molecules e.g. dNTPs/ddNTPs followed by reassembly and amplification is described. The utility of this method for improving protein structure and/or function is demonstrated by creating novel sarcosine oxidase variants and by recombining human placental alkaline phosphates and calf intestinal alkaline phosphatase for better mutants with improved properties.
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3.发明公开VARIANTS OF SOLUBLE PYRROLOQUINOLINE QUINONE-DEPENDENT GLUCOSE DEHYDROGENASE 有权可溶性PYRROLOQUINOLIN醌依赖性葡萄糖脱氢酶的变异研究
公开(公告)号：EP1332216A1
公开(公告)日：2003-08-06
申请号：EP01988775.1
申请日：2001-10-20
发明人： KRATZSCH, Peter , SCHMUCK, Rainer , BUNK, Daniela , SHAO, Zhixin , THYM, Detlef , KNAPPE, Wolfgang-Reinhold
CPC分类号： C12N9/0006
摘要： The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different applications of these s-GDH variants, particularly for determining concentrations of sugar, especially of glucose in a sample.
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公开(公告)号：EP4400515A3
公开(公告)日：2024-10-23
申请号：EP24168363.0
申请日：2021-04-23
发明人： SHAO, Zhixin
摘要： The present invention relates to proteins, particularly antibodies such as anti-CD20/anti-CD3 bispecific antibodies and anti a-synuclein antibodies, having monogalactosylated (Gl) and digalactosylated (G2) glycans. More particular, the present invention relates to galactosylation engineering to generate proteins with improved therapeutic properties, including proteins with increased titer. Further, the invention relates to a cell culture medium and a mammalian cell as well as methods using said cell culture medium and said mammalian cell for producing said proteins. Moreover, the present invention relates to the use of said antibodies as a medicament such as for the treatment of cancer, particularly cancer associated with B-cells, or Parkinson's disease.
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公开(公告)号：EP4400515A2
公开(公告)日：2024-07-17
申请号：EP24168363.0
申请日：2021-04-23
发明人： SHAO, Zhixin
IPC分类号： C07K16/28
CPC分类号： C07K2317/3120130101 , C07K2317/4120130101 , C07K2317/7120130101 , C07K2317/7220130101 , C07K16/18 , A61P35/00 , C07K16/2809 , C07K16/2887
摘要： The present invention relates to proteins, particularly antibodies such as anti-CD20/anti-CD3 bispecific antibodies and anti a-synuclein antibodies, having monogalactosylated (Gl) and digalactosylated (G2) glycans. More particular, the present invention relates to galactosylation engineering to generate proteins with improved therapeutic properties, including proteins with increased titer. Further, the invention relates to a cell culture medium and a mammalian cell as well as methods using said cell culture medium and said mammalian cell for producing said proteins. Moreover, the present invention relates to the use of said antibodies as a medicament such as for the treatment of cancer, particularly cancer associated with B-cells, or Parkinson's disease.
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公开(公告)号：EP3717656A1
公开(公告)日：2020-10-07
申请号：EP18811260.1
申请日：2018-11-29
发明人： GREPPMAIR, Katrin , LINK, Thomas , SHAO, Zhixin
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