公开(公告)号：EP1828106B1

公开(公告)日：2012-10-31

申请号：EP05825390.7

申请日：2005-12-15

申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

发明人： HUI, Raymond, A. ,  VITONE, Stephen, S.

IPC分类号： C07C233/18 ,  C07C233/31 ,  C07C217/06 ,  C07D207/36 ,  C07C271/16 ,  C07C331/28 ,  C07K16/44 ,  C07D207/404

CPC分类号： C07C331/28 ,  C07C233/18 ,  C07C271/16 ,  C07D207/404 ,  C07K16/44 ,  Y02P20/55 ,  Y10S436/815 ,  Y10S436/901 ,  Y10T436/13 ,  Y10T436/173845

公开(公告)号：EP1828106A2

公开(公告)日：2007-09-05

申请号：EP05825390.7

申请日：2005-12-15

申请人： Roche Diagnostics GmbH ,  F. Hoffmann-Roche AG

发明人： HUI, Raymond, A. ,  VITONE, Stephen, S.

IPC分类号： C07C233/31 ,  C07C217/06 ,  C07D207/36 ,  A61K31/16 ,  A61K31/40 ,  A61K31/135

CPC分类号： C07C331/28 ,  C07C233/18 ,  C07C271/16 ,  C07D207/404 ,  C07K16/44 ,  Y02P20/55 ,  Y10S436/815 ,  Y10S436/901 ,  Y10T436/13 ,  Y10T436/173845

摘要： Compounds of methamphetamine derivatives having a meta-substituted alkyl linker on the benzene ring and a protective group on the nitrogen of the methamphetamine hapten. Such compounds have the structure (I) wherein R1 is an alkyl linker comprising 2-15 carbon atoms and 0-6 heteroatoms, R2 is a leaving group, and R3 is a protecting group. Compounds having the formula (II), wherein R1 is an alkyl linker comprising 2-15 carbon atoms and 0-6 heteroatoms and R2 is a polysaccharide or a microparticle. Immunoassays for determining metamphetamine in a sample and test kits for use in determining methamphetamine in a sample.

摘要翻译： 在苯环上具有间位取代的烷基连接体并且在甲基苯丙胺半抗原的氮上具有保护基团的甲基苯丙胺衍生物化合物。 这样的化合物具有结构（I），其中R 1是包含2-15个碳原子和0-6个杂原子的烷基连接基，R 2是离去基团，并且R 3是保护基。 具有式（II）的化合物，其中R 1是包含2-15个碳原子和0-6个杂原子的烷基连接基，并且R 2是多糖或微粒。 用于测定样品中甲基苯丙胺的免疫分析和用于测定样品中甲基苯丙胺的测试试剂盒。

公开(公告)号：EP1824883A2

公开(公告)日：2007-08-29

申请号：EP05804954.5

申请日：2005-12-08

申请人： Roche Diagnostics GmbH ,  F. Hoffmann-Roche AG

发明人： HUI, Raymond, A. ,  SIGLER, Gerald, F. ,  ROOT, Richard, T. ,  YUAN, Wie

IPC分类号： C07K14/81 ,  C07D217/26 ,  C07D471/04 ,  A61P31/18

CPC分类号： C07K14/81 ,  C07D401/12 ,  C07D401/14 ,  Y10S436/815 ,  Y10S530/809

摘要： Analogs of saquinavir functionalized at the quinoline portion of the molecule are described. These include pyridyl analogs (replacing the quinoline ring) with a functional handle out of the ring allowing for elaboration with linkers terminated by a functional group, such as an activated ester which are useful for attaching the molecule to other entities such as proteins, polysaccharides, and the like. Analogs of saquinavir derivatized out of the quinoline ring are also described. Further described are antibodies generated in response to pyridyl analogs and quinoline analogs of saquinavir.