公开(公告)号：EP2659275B1

公开(公告)日：2017-11-22

申请号：EP11810589.9

申请日：2011-12-21

申请人： Roche Diagnostics GmbH ,  F. Hoffmann-La Roche AG

发明人： GERG, Michael ,  HEINDL, Dieter ,  MERTENS, Alfred ,  RUTZ, Christoph ,  SCHRAEML, Michael ,  SOUKUPOVA, Monika ,  SUSTMANN, Claudio ,  TACKE, Michael ,  VAN DIECK, Jan

IPC分类号： C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  C07K16/44 ,  G01N33/68

CPC分类号： C07K16/468 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6857

摘要： A bivalent binding agent, capable of binding a polypeptide dimer, consisting of two monovalent binders linked to each other via a linker, the first monovalent binder binds an epitope of a first target polypeptide comprised in said dimer and the second monovalent binder binds to an epitope of a second target polypeptide comprised in said dimer. Each monovalent binder has a Kdiss in the range of 5×10-3/sec to 10-4/sec, and the bivalent binding agent has a Kdiss of 3×10-5/sec or less. Methods of making and using such bivalent binding agent in histological staining procedures are also disclosed.

公开(公告)号：EP4400842A1

公开(公告)日：2024-07-17

申请号：EP22864187.4

申请日：2022-08-08

申请人： HITACHI HIGH-TECH CORPORATION ,  F. Hoffmann-La Roche AG ,  Roche Diagnostics GmbH

发明人： MIYADA, Yuki ,  TAKADA, Eiichiro ,  HAMASAKI, Koshin ,  JOJI, Akira ,  FOESTER, Elisabeth ,  RUTZ, Christoph

IPC分类号： G01N35/00

CPC分类号： G01N35/00

摘要： Provided are an automatic analyzer that can decrease waiting time for a user and reduce running costs as compared with in the past and an operation method for the automatic analyzer. The analyzer includes: a first mechanism group 202 that is used only in analysis for biochemical items; a second mechanism group 203 that is used only in analysis for immunological items; a common mechanism group 204 that is used in analysis for both biochemical items and immunological items; and a control part 116 that activates the second mechanism group 203 and common mechanism group 204 without activating the first mechanism group 202 when analysis for biochemical items is not required, and activates the first mechanism group 202 and common mechanism group 204 without activating the second mechanism group 203 when analysis for immunological items is not required.

公开(公告)号：EP2659275A2

公开(公告)日：2013-11-06

申请号：EP11810589.9

申请日：2011-12-21

申请人： Roche Diagnostics GmbH ,  F.Hoffmann-La Roche AG

发明人： GERG, Michael ,  HEINDL, Dieter ,  MERTENS, Alfred ,  RUTZ, Christoph ,  SCHRAEML, Michael ,  SOUKUPOVA, Monika ,  SUSTMANN, Claudio ,  TACKE, Michael ,  VAN DIECK, Jan

IPC分类号： G01N33/68 ,  C07K16/46

CPC分类号： C07K16/468 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/6857

摘要： A bivalent binding agent, capable of binding a polypeptide dimer, consisting of two monovalent binders linked to each other via a linker, the first monovalent binder binds an epitope of a first target polypeptide comprised in said dimer and the second monovalent binder binds to an epitope of a second target polypeptide comprised in said dimer. Each monovalent binder has a Kdiss in the range of 5×10-3/sec to 10-4/sec, and the bivalent binding agent has a Kdiss of 3×10-5/sec or less. Methods of making and using such bivalent binding agent in histological staining procedures are also disclosed.

摘要翻译： 能够结合多肽二聚体的二价结合剂，其由通过接头彼此连接的两个单价结合物组成，第一单价键合物结合包含在所述二聚体中的第一靶多肽的表位，第二单价键结合结合到表位 的包含在所述二聚体中的第二目标多肽。 每个一价粘合剂的Kdiss的范围为5×10 -3 /秒至10 -4 /秒，二价结合剂的Kdiss为3×10-5 /秒以下。 还公开了在组织学染色方法中制备和使用这种二价结合剂的方法。