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公开(公告)号：EP4034558A1
公开(公告)日：2022-08-03
申请号：EP20785923.2
申请日：2020-09-25
IPC分类号： C07K16/24 , C07K14/715 , C07K16/28 , A61K39/00
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公开(公告)号：EP4010366A1
公开(公告)日：2022-06-15
申请号：EP20760778.9
申请日：2020-08-06
发明人： LIEDKE, Sarah , KRONER, Frank , SCHRAEML, Michael
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公开(公告)号：EP3562845A2
公开(公告)日：2019-11-06
申请号：EP17832237.6
申请日：2017-12-22
发明人： GERG, Michael , HEINDL, Dieter , HILLRINGHAUS, Lars , HIRZEL, Klaus , HOJER, Caroline Dorothea , HUBER, Florian , JOSEL, Hans-Peter , MEIER, Thomas , SCHRAEML, Michael , VOSS, Edgar
IPC分类号： C07K16/44 , C07D495/04 , G01N33/82 , A61K47/51 , A61K31/4188 , C07K16/00 , C07K16/40 , G01N33/53
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公开(公告)号：EP3036259B1
公开(公告)日：2018-02-21
申请号：EP14777674.4
申请日：2014-10-02
发明人： SOUKUPOVA, Monika , SCHRAEML, Michael , BOSSENMAIER, Birgit , ROCHE, Patrick C. , GERG, Michael , DZIADEK, Sebastian
IPC分类号： C07K16/32
CPC分类号： C07K16/2863 , C07K16/3023 , C07K16/3046 , C07K16/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , G01N1/30 , G01N33/57492 , G01N33/74 , G01N2001/302 , G01N2333/71
摘要： The present invention relates to isolated antibodies, or an antigen portions thereof, which bind to human HER3. The novel antibodies are of great utility since they allow for the sensitive and specific detection of human HER3. Detection of human HER3 is, e.g., possible in a tissue sample, even when such tissue sample is a formalin-fixed paraffin embedded tissue (FFPET) sample.
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5.发明公开A METHOD FOR DETERMINING THE TOTAL AMOUNT AND/OR CONCENTRATION OF AN ANALYTE IN THE PRESENCE OF A BINDING MOLECULE AS WELL AS KITS, COMPOSITIONS AND USES RELATING THERETO 有权方法用于测定分析物的总的和/或浓度IN PRESENCE的结合分子和试剂盒，组合物和用途
公开(公告)号：EP3066469A1
公开(公告)日：2016-09-14
申请号：EP14792817.0
申请日：2014-11-03
IPC分类号： G01N33/53 , G01N33/536
CPC分类号： G01N33/543 , G01N33/53
摘要： The present invention relates to a method for determining the total amount and/or concentration of an analyte in the presence of a binding molecule as well as kits, compositions and uses relating thereto.
摘要翻译： 本发明涉及一种用于采矿确定性在结合分子的存在以及试剂盒，组合物的分析物的总量和/或浓度和使用与其相关。
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6.发明公开
公开(公告)号：EP4217399A1
公开(公告)日：2023-08-02
申请号：EP21782511.6
申请日：2021-09-21
发明人： SWIATEK-DE LANGE, Magdalena , SIEBENHAAR, Joanna , JONES, Carol , PRITCHETT, Thomas , MURANYI, Andrea , HOJER, Caroline Dorothea , GERG, Michael , HILLRINGHAUS, Lars , TABARES, Gloria , ROESSLER, Christian , SCHRAEML, Michael , SINGH, Shalini , KOTT, Theresa
IPC分类号： C07K16/30
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公开(公告)号：EP3781600A1
公开(公告)日：2021-02-24
申请号：EP19715804.1
申请日：2019-04-16
发明人： DUEFEL, Hartmut , ENGEL, Alfred , KRONER, Frank , MEIER, Thomas , RUTZ, Sandra , SCHRAEML, Michael , TABARES, Gloria , KURTKAYA, Ulrike , PINCHUK, Boris , ZIMMERMANN, Christina
IPC分类号： C07K16/40 , G01N33/577
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公开(公告)号：EP3765498A1
公开(公告)日：2021-01-20
申请号：EP19710668.5
申请日：2019-03-12
发明人： LIEDKE, Sarah , KRONER, Frank , SCHRAEML, Michael
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公开(公告)号：EP2659275B1
公开(公告)日：2017-11-22
申请号：EP11810589.9
申请日：2011-12-21
发明人： GERG, Michael , HEINDL, Dieter , MERTENS, Alfred , RUTZ, Christoph , SCHRAEML, Michael , SOUKUPOVA, Monika , SUSTMANN, Claudio , TACKE, Michael , VAN DIECK, Jan
CPC分类号： C07K16/468 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K16/44 , C07K2317/31 , C07K2317/34 , C07K2317/55 , C07K2317/92 , C07K2317/94 , G01N33/6857
摘要： A bivalent binding agent, capable of binding a polypeptide dimer, consisting of two monovalent binders linked to each other via a linker, the first monovalent binder binds an epitope of a first target polypeptide comprised in said dimer and the second monovalent binder binds to an epitope of a second target polypeptide comprised in said dimer. Each monovalent binder has a Kdiss in the range of 5×10-3/sec to 10-4/sec, and the bivalent binding agent has a Kdiss of 3×10-5/sec or less. Methods of making and using such bivalent binding agent in histological staining procedures are also disclosed.
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