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公开(公告)号：EP3036259B1
公开(公告)日：2018-02-21
申请号：EP14777674.4
申请日：2014-10-02
发明人： SOUKUPOVA, Monika , SCHRAEML, Michael , BOSSENMAIER, Birgit , ROCHE, Patrick C. , GERG, Michael , DZIADEK, Sebastian
IPC分类号： C07K16/32
CPC分类号： C07K16/2863 , C07K16/3023 , C07K16/3046 , C07K16/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , G01N1/30 , G01N33/57492 , G01N33/74 , G01N2001/302 , G01N2333/71
摘要： The present invention relates to isolated antibodies, or an antigen portions thereof, which bind to human HER3. The novel antibodies are of great utility since they allow for the sensitive and specific detection of human HER3. Detection of human HER3 is, e.g., possible in a tissue sample, even when such tissue sample is a formalin-fixed paraffin embedded tissue (FFPET) sample.
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公开(公告)号：EP3833435A1
公开(公告)日：2021-06-16
申请号：EP19846750.8
申请日：2019-08-08
申请人： F. Hoffmann-La Roche AG , Ventana Medical Systems, Inc. , Prothena Biosciences Limited , Roche Diagnostics GmbH
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公开(公告)号：EP3036259A1
公开(公告)日：2016-06-29
申请号：EP14777674.4
申请日：2014-10-02
发明人： SOUKUPOVA, Monika , SCHRAEML, Michael , BOSSENMAIER, Birgit , ROCHE, Patrick C. , GERG, Michael , DZIADEK, Sebastian
IPC分类号： C07K16/32
CPC分类号： C07K16/2863 , C07K16/3023 , C07K16/3046 , C07K16/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , G01N1/30 , G01N33/57492 , G01N33/74 , G01N2001/302 , G01N2333/71
摘要： The present invention relates to isolated antibodies, or an antigen portions thereof, which bind to human HER3. The novel antibodies are of great utility since they allow for the sensitive and specific detection of human HER3. Detection of human HER3 is, e.g., possible in a tissue sample, even when such tissue sample is a formalin-fixed paraffin embedded tissue (FFPET) sample.
摘要翻译： 本发明涉及与人HER3结合的分离的抗体或其抗原部分。 新型抗体具有很好的实用性，因为它们允许对人HER3的敏感和特异性检测。 即使这样的组织样品是福尔马林固定的石蜡包埋组织（FFPET）样品，人类HER3的检测也可能在组织样品中。
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公开(公告)号：EP2880042B1
公开(公告)日：2017-02-01
申请号：EP13744980.7
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus, Miguel , JOSEL, Hans-Peter , LONGHI, Elena , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , C09K2211/14 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/1475 , C09K2211/1491 , C09K2211/185 , G01N33/582 , G01N2458/30
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公开(公告)号：EP2882764B1
公开(公告)日：2017-03-01
申请号：EP13744979.9
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus, Miguel , JOSEL, Hans-Peter , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1003 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1059 , C09K2211/1074 , C09K2211/14 , C09K2211/185 , G01N33/582
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公开(公告)号：EP2882823B1
公开(公告)日：2017-02-22
申请号：EP13750504.6
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus Miguel , JOSEL, Hans-Peter , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1007 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
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公开(公告)号：EP3138580A1
公开(公告)日：2017-03-08
申请号：EP16189277.3
申请日：2013-07-04
发明人： BRINKMANN, Ulrich , GEORGES, Guy , HOFFMANN, Eike , BENZ, Joerg , HAAS, Alexander , GROTE, Michael , DZIADEK, Sebastian , DENGL, Stefan
IPC分类号： A61K47/68 , C07K16/00 , A61K39/395
CPC分类号： A61K47/48507 , A61K39/385 , A61K47/6835 , A61K47/6879 , A61K47/6897 , A61K2039/6056 , A61K2039/627 , B82Y5/00 , C07K16/00 , C07K16/16 , C07K16/2896 , C07K16/40 , C07K16/44 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/624 , C07K2317/94 , G01N33/6857
摘要： Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.
摘要翻译： 本文报道了包含特异性结合抗原的抗原和抗体的缀合物，其中在抗体的CDR2中的抗原和氨基酸残基之间形成共价键，抗体包含在氨基酸位置53处的半胱氨酸残基（ 根据Kabat）在重链CDR2及其用途。
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9.发明公开IMMUNOCONJUGATES FOR SPECIFIC INDUCTION OF T CELL CYTOTOXICITY AGAINST A TARGET CELL 审中-公开免疫偶联物用于特异性诱导T细胞对靶细胞的细胞毒性
公开(公告)号：EP3258969A1
公开(公告)日：2017-12-27
申请号：EP16705139.0
申请日：2016-02-17
IPC分类号： A61K47/50
CPC分类号： A61K47/6811 , A61K47/642 , A61K47/65 , A61K47/6851 , A61K2039/505 , A61K2039/507 , A61K2039/627 , C07K16/2803 , C07K16/2818 , C07K16/2896 , C07K2317/77
摘要： The present invention relates to immunoconjugates for specific induction of T cell cytotoxicity against a target cell, comprising at least one T cell response eliciting peptide that is presentable via MHC class I coupled to a target cell binding moiety via a cleavable bond and methods of their production and uses thereof.
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公开(公告)号：EP3194610A1
公开(公告)日：2017-07-26
申请号：EP15763330.6
申请日：2015-09-15
发明人： BENTO PEREIRA DA SILVA, Ana Patricia , DZIADEK, Sebastian , ECABERT, Barbara , GERG, Michael , NOGOCEKE, Everson , MARCINOWSKI, Moritz , REIS, Bernhard , SCHINDLER, Thomas , THERON, Michel Achille Edouard
IPC分类号： C12Q1/37 , G01N33/569 , G01N33/573 , C07K16/00 , C07K16/28
摘要： The present invention relates to a method for monitoring Cathepsin S inhibitor activity in tissue samples of animals comprising: a) providing a tissue sample of an animal to whom a Cathepsin S inhibitor has been administered or providing a tissue sample of an animal that was contacted in vitro with a Cathepsin S inhibitor, wherein the tissue samples comprise white blood cells, b) measuring li p10 peptide level in white blood cells of the tissue sample of step a) by flow cytometry and c) correlating li p10 peptide level in white blood cells to Cathepsin S inhibitor dose, wherein a Cathepsin S inhibitor leads to increased level of li p10 peptide in the white blood cells.
摘要翻译： 本发明涉及用于监测动物组织样品中的组织样品中的组织样品中的组织样品S抑制剂活性的方法，包括：a）提供给予组织样品的组织样品，其中组织样品已经施用组织样品或提供接触过的动物的组织样品 其中所述组织样品包含白细胞，b）通过流式细胞术测量步骤a）的组织样品的白血细胞中的li p10肽水平，和c）将白血细胞中的li p10肽水平相关联 至组织蛋白酶S抑制剂剂量，其中组织蛋白酶S抑制剂导致白血细胞中li p10肽水平升高。
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