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1.发明公开Device for performing multiple analyses in parallel 审中-公开Vorrichtung zur parallelenDurchführungmehrerer Analysen
公开(公告)号：EP1977829A1
公开(公告)日：2008-10-08
申请号：EP07006512.3
申请日：2007-03-29
发明人： Sarofim, Emad , Kopp, Martin, Dr. , Glauser, Michael , Siljegovic, Vuk, Dr. , Curcio, Mario, Dr.
CPC分类号： B01L3/5088 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L2200/0642 , B01L2200/0684 , B01L2300/0829 , B01L2300/0864 , B01L2300/14 , B01L2400/0406 , B01L2400/0694
摘要： The invention is directed to a device for performing multiple analyses from one sample in parallel with a liquid sample. It is proposed that the device comprises reaction sections (7) connected to a venting system comprising venting channels (8), wherein the capillary force of the reaction sections (7) to the sample is greater than the capillary force of the venting system and the venting system is designed for venting several reaction sections (7) in common.
摘要翻译： 本发明涉及一种用于与液体样品并行地从一个样品进行多次分析的装置。 提出该装置包括连接到包括通气通道（8）的排气系统的反应部分（7），其中反应部分（7）对样品的毛细力大于排气系统的毛细管力， 排气系统设计用于排放多个反应段（7）。
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2.发明公开Device having a reversibly closable fluid valve 审中-公开Vorrichtung mit reversibel verschliessbarem Fluidventil
公开(公告)号：EP1905514A1
公开(公告)日：2008-04-02
申请号：EP06020670.3
申请日：2006-09-30
CPC分类号： B29C45/1676 , B01L3/502707 , B01L3/502738 , B01L2300/0825 , B01L2400/0638 , B01L2400/0655 , B29C45/0053 , B29C2045/0094 , B29L2031/7506 , B29L2031/756 , F16K99/0001 , F16K99/0026 , F16K99/0034 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , G01N2035/00247
摘要： A device comprising a valve in a tubular channel (3) to open and close said channel (3), said valve being formed by a first wall (2) of said tubular channel, said first wall (2) being made of a thermoplastic elastomeric material, and a second wall being made of a thermoplastic material, said first wall (2) and said second wall being irreversibly bonded to each other is disclosed. The device can be used advantageously for reliable analyses in automated procedures, e.g., to control fluid flows within said device.
摘要翻译： 一种装置，包括在管状通道（3）中的阀，以打开和关闭所述通道（3），所述阀由所述管状通道的第一壁（2）形成，所述第一壁（2）由热塑性弹性体 材料和由热塑性材料制成的第二壁，所述第一壁（2）和所述第二壁彼此不可逆地接合。 该装置可以有利地用于自动化程序中的可靠分析，例如控制所述装置内的流体流动。
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公开(公告)号：EP1525919A1
公开(公告)日：2005-04-27
申请号：EP04025004.5
申请日：2004-10-21
CPC分类号： B01J19/0093 , B01J2219/00889 , B01J2219/00891 , B01L3/50273 , B01L3/502738 , B01L2200/0621 , B01L2300/0806 , B01L2300/0816 , B01L2400/0406 , B01L2400/0688 , B01L2400/084 , F16K99/0001 , F16K99/0017 , F16K2099/0074 , F16K2099/0076 , F16K2099/0084
摘要： The present invention is related to a microfluidic device capable of conveying a liquid (19) by capillary forces. Said microfluidic device comprises a microfluidic channel system (10, 12, 14; 43, 44; 63, 64) with
i) one liquid supply compartment (81, 91, 101) and ii) a first channel (10) connected to the liquid supply compartment (81, 91, 101), having at least one non-closing valve (1, 65, 73) located downstream of the liquid supply compartment (81, 91, 101) and
ii) a second channel (12, 43, 44). The second channel (12, 43, 44) branches-off from the first channel (10) downstream of the liquid supply compartment (81, 91, 101) but upstream of the at least one non-closing valve (1, 65, 73) and which re-united with the first channel (10) at the location of the non-closing valve (1, 65, 73) to form an outlet channel (14). The second channel (12, 43, 44) does not contain any non-closing or closing valve thus creating an unobstructed liquid flow path connecting the liquid supply compartment (81, 91, 101) with the outlet channel (14).-
公开(公告)号：EP1748081A1
公开(公告)日：2007-01-31
申请号：EP05106980.5
申请日：2005-07-28
CPC分类号： B01L7/52 , B01L3/508 , B01L2300/1816 , B01L2300/1827 , B01L2300/1838 , B01L2300/1861 , C12Q1/686 , H05B6/806 , C12Q2563/149
摘要： A method is provided that conveniently allows rapid amplification of nucleic acids. Two different heat sources are used to heat the reaction mixture.
摘要翻译： 提供了方便地允许核酸的快速扩增的方法。 使用两种不同的热源来加热反应混合物。
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5.发明公开
公开(公告)号：EP1878802A1
公开(公告)日：2008-01-16
申请号：EP06014680.0
申请日：2006-07-14
CPC分类号： B01L3/502715 , B01L3/502707 , B01L2200/10 , B01L2300/0809
摘要： The invention is directed to a disposable sample holding and processing device (1) dimensioned for being operated in a nucleic acid amplification apparatus for analyzing a liquid sample containing a nucleic acid by a nucleic acid amplification technique. The device (1) comprises chambers (15, 16) and channels (44) designed to perform the steps of capturing, amplification and detection of the nucleic acid within the device (1), and optionally also a lysis chamber (3). The binding chamber (15) contains a solid phase (14) for immobilization of a component of the sample to be analyzed, and the amplification chamber (16) is connected to the binding chamber (15) by a fluid channel (44). The device (1) comprises a rigid body (42) and at least one channel (44), the binding chamber (15) and the amplification chamber (16) are situated on side-surfaces (50) of the body (42), each of those side-surfaces (50), on which a channel (44), the binding chamber (15) or the amplification chamber (16) is situated, is covered by at least one wall (41) and these side-surfaces (50) are substantially vertical planes when the device (1) is operated in the nucleic acid amplification apparatus.
摘要翻译： 本发明涉及一种一次性样品保持和处理装置（1）的尺寸用于在核酸扩增装置被操作用于分析含有核酸通过核酸扩增技术的液体样品。 的装置（1）包括腔室（15，16）和设计为在装置（1）内执行捕获，扩增和核酸的检测步骤的通道（44），因此，任选的溶解室（3）。 的结合室（15）包含用于样品的组分的固定化在固相（14），以进行分析，并且所述扩增腔室（16）被连接到由一个流体通道（44）的结合室（15）。 所述装置（1）包括所述主体的刚性体（42）和至少一个通道（44），所述结合室（15）和放大腔室（16）位于上侧的表面（50）（42） 每个在其上的通道（44），该结合室（15）或所述扩增腔室（16）位于这些侧表面（50）的，由至少一个壁（41）和合成的侧表面（覆盖 50）是大体垂直的平面当装置（1）在核酸扩增装置被操作。
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6.发明公开Apparatus for performing nucleic acid analysis 审中-公开Vorrichtung zurDurchführungvonNukleinsäureanalyse
公开(公告)号：EP1878496A1
公开(公告)日：2008-01-16
申请号：EP06014681.8
申请日：2006-07-14
发明人： Sarofim, Emad , Elsenhans, Olivier, Dr. , Kopp, Martin, Dr. , Wahl, Hans-Peter, Dr. , Savatic, Goran , Hutter, Roland Christof
CPC分类号： B01L3/502715 , G01N35/0099 , G01N2035/00346
摘要： The embodiments of the present invention are directed to an automatic apparatus (55), which is designed for performing nucleic acid analysis, optionally including sample preparation, with integrated disposable sample holding and processing devices (1), which devices (1) comprise a sample to be analyzed with the apparatus (55). The apparatus (55) comprises workstations (17, 40) for receiving, holding and processing such integrated disposable devices (1), a reagents station (56) for reagents (25), transfer means (36) for performing movements of an actuator, fluid actuation means for processing the sample (32) and reagents in said disposable devices (1), temperature control means (37) for heating or cooling, detection means for measuring a property of the processed samples (32), and control means for controlling the sample (32) preparation, the handling of the disposable devices (1) and the sample analysis performed by the apparatus (55).
摘要翻译： 本发明的实施例涉及一种自动装置（55），其被设计用于执行核酸分析，任选地包括样品制备，具有集成的一次性样品保持和处理装置（1），所述装置（1）包括样品 用装置（55）进行分析。 装置（55）包括用于接收，保持和处理这种集成的一次性装置（1）的工作站（17,40），用于试剂（25）的试剂台（56），用于执行致动器的运动的传送装置（36） 用于处理所述一次性装置（1）中的样品（32）和试剂的流体致动装置，用于加热或冷却的温度控制装置（37），用于测量经处理样品（32）的性质的检测装置，以及用于控制 样品（32）制备，一次性装置（1）的处理和由装置（55）进行的样品分析。
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公开(公告)号：EP1658898A1
公开(公告)日：2006-05-24
申请号：EP04027624.8
申请日：2004-11-20
发明人： Kopp, Martin, Dr.
摘要： The present invention is directed to methods, devices and computer programs for preparing nucleic acids from a template nucleic acid by subjecting a sample to thermocycles. After a first number of thermocycles, a partial amount of the reaction mixture is being subjected to a second number of thermocycles. This two step amplification method allows to speed up overall reaction time without affecting the limit of detection.
摘要翻译： 本发明涉及通过使样品经历热循环从模板核酸制备核酸的方法，装置和计算机程序。 在第一批次的热循环之后，部分量的反应混合物进行第二次热循环。 这种两步扩增方法可以在不影响检测极限的情况下加快整体反应时间。
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