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公开(公告)号：EP2880042A1
公开(公告)日：2015-06-10
申请号：EP13744980.7
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus, Miguel , JOSEL, Hans-Peter , LONGHI, Elena , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , C09K2211/14 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/1475 , C09K2211/1491 , C09K2211/185 , G01N33/582 , G01N2458/30
摘要： The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
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公开(公告)号：EP2882823A2
公开(公告)日：2015-06-17
申请号：EP13750504.6
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus Miguel , JOSEL, Hans-Peter , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1007 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
摘要： The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
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公开(公告)号：EP2880123A2
公开(公告)日：2015-06-10
申请号：EP13744978.1
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus Miguel , JOSEL, Hans-Peter , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
摘要： The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
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公开(公告)号：EP2882764A1
公开(公告)日：2015-06-17
申请号：EP13744979.9
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus, Miguel , JOSEL, Hans-Peter , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K11/07 , C09K2211/1003 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/1059 , C09K2211/1074 , C09K2211/14 , C09K2211/185 , G01N33/582
摘要： The present invention relates to novel iridium-based Ir(III) luminescent complexes, conjugates comprising these complexes as a label and their application, e.g. in the electrochemiluminescence based detection of an analyte.
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公开(公告)号：EP2880123B1
公开(公告)日：2016-10-05
申请号：EP13744978.1
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus Miguel , JOSEL, Hans-Peter , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C09K2211/14 , C09K2211/1408 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/185 , G01N33/582
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公开(公告)号：EP2869848A1
公开(公告)日：2015-05-13
申请号：EP13737565.5
申请日：2013-07-04
发明人： BENZ, Joerg , BRINKMANN, Ulrich , DENGL, Stefan , DZIADEK, Sebastian , GEORGES, Guy , GROTE, Michael , HAAS, Alexander , HOFFMANN, Eike
IPC分类号： A61K47/48 , C07K16/00 , A61K39/395
CPC分类号： A61K47/48507 , A61K39/385 , A61K47/6835 , A61K47/6879 , A61K47/6897 , A61K2039/6056 , A61K2039/627 , B82Y5/00 , C07K16/00 , C07K16/16 , C07K16/2896 , C07K16/40 , C07K16/44 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/624 , C07K2317/94 , G01N33/6857
摘要： Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.
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7.发明公开A PHARMACEUTICAL COMPOSITION OF A COMPLEX OF AN ANTI-DIG ANTIBODY AND DIGOXIGENIN THAT IS CONJUGATED TO A PEPTIDE 审中-公开关于复从反DIG-抗体并与肽连接地高辛药物组合物
公开(公告)号：EP2661282A1
公开(公告)日：2013-11-13
申请号：EP11804712.5
申请日：2011-12-30
IPC分类号： A61K47/48 , A61K39/385 , A61K39/395 , A61P35/00 , A61P3/00 , A61P43/00
CPC分类号： A61K47/48692 , A61K39/385 , A61K47/554 , A61K47/6883
摘要： The present invention relates to a pharmaceutical composition of complex of a monospecific antibody that binds to digoxigenin, and a digoxigenin-conjugated peptide, to the isolated or recovered complex as well as to a method of producing such complex or composition. Furthermore the use of such a pharmaceutical composition as a medicament is described.
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公开(公告)号：EP2869848B1
公开(公告)日：2016-09-21
申请号：EP13737565.5
申请日：2013-07-04
发明人： BENZ, Joerg , BRINKMANN, Ulrich , DENGL, Stefan , DZIADEK, Sebastian , GEORGES, Guy , GROTE, Michael , HAAS, Alexander , HOFFMANN, Eike
IPC分类号： A61K47/48 , C07K16/00 , A61K39/385 , B82Y5/00 , C07K16/16 , C07K16/28 , C07K16/40 , C07K16/44 , C07K16/46 , G01N33/68 , A61K39/00
CPC分类号： A61K47/48507 , A61K39/385 , A61K47/6835 , A61K47/6879 , A61K47/6897 , A61K2039/6056 , A61K2039/627 , B82Y5/00 , C07K16/00 , C07K16/16 , C07K16/2896 , C07K16/40 , C07K16/44 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/624 , C07K2317/94 , G01N33/6857
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公开(公告)号：EP3036259B1
公开(公告)日：2018-02-21
申请号：EP14777674.4
申请日：2014-10-02
发明人： SOUKUPOVA, Monika , SCHRAEML, Michael , BOSSENMAIER, Birgit , ROCHE, Patrick C. , GERG, Michael , DZIADEK, Sebastian
IPC分类号： C07K16/32
CPC分类号： C07K16/2863 , C07K16/3023 , C07K16/3046 , C07K16/32 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94 , G01N1/30 , G01N33/57492 , G01N33/74 , G01N2001/302 , G01N2333/71
摘要： The present invention relates to isolated antibodies, or an antigen portions thereof, which bind to human HER3. The novel antibodies are of great utility since they allow for the sensitive and specific detection of human HER3. Detection of human HER3 is, e.g., possible in a tissue sample, even when such tissue sample is a formalin-fixed paraffin embedded tissue (FFPET) sample.
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公开(公告)号：EP2880042B1
公开(公告)日：2017-02-01
申请号：EP13744980.7
申请日：2013-08-02
发明人： BERGMANN, Frank , CYSEWSKI, Robert , DE COLA, Luisa , DZIADEK, Sebastian , FERNANDEZ HERNANDEZ, Jesus, Miguel , JOSEL, Hans-Peter , LONGHI, Elena , SEIDEL, Christoph
CPC分类号： C07F15/0033 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1059 , C09K2211/14 , C09K2211/1416 , C09K2211/1425 , C09K2211/1441 , C09K2211/1466 , C09K2211/1475 , C09K2211/1491 , C09K2211/185 , G01N33/582 , G01N2458/30
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