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公开(公告)号：EP3408219A1
公开(公告)日：2018-12-05
申请号：EP17745013.7
申请日：2017-01-27
CPC分类号： G01N33/48721
摘要： A DNA or genome sequencing structure is disclosed. The structure includes an electrode pair, each electrode having a tip-shaped end, the electrodes separated by a nanogap defined by facing tip-shaped ends; at least one conductive island deposited at or near each tip-shaped end; and a biomolecule having two ends, each end attached to the conductive islands in the electrode pair such that one biomolecule bridges over the nanogap in the electrode pair, wherein nucleotide interactions with the biomolecule provides electronic monitoring of DNA or genome sequencing without the use of a fluorescing element.
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公开(公告)号：EP3545076A1
公开(公告)日：2019-10-02
申请号：EP17874229.2
申请日：2017-11-22
发明人： CHOI, Chulmin , JIN, Sungho , MERRIMAN, Barry, L. , MOLA, Paul , GEISER, Tim
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公开(公告)号：EP3571286A1
公开(公告)日：2019-11-27
申请号：EP17893481.6
申请日：2017-11-22
发明人： CHOI, Chulmin , JIN, Sungho , MERRIMAN, Barry, L. , MOLA, Paul , GEISER, Tim
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公开(公告)号：EP4137808A1
公开(公告)日：2023-02-22
申请号：EP22186552.0
申请日：2017-01-27
发明人： CHOI, Chulmin , JIN, Sungho , MOLA, Paul , MERRIMAN, Barry
IPC分类号： G01N27/327
摘要： The present invention provides a method of making a genome or DNA sequencing device, the method comprising the steps of:
(a) disposing an array of electrode pairs (71) on a substrate, each electrode within a given pair of electrodes having a tip-shaped end, with the electrodes in each pair separated by a nanogap defined by tip-shaped ends facing one another;
(b) electrodepositing gold at each tip-shaped end by applying a voltage to the electrode pair whereby high current density in the region of each tip-shaped end of each electrode directs preferential electrodeposition of gold to each tip-shaped end to form a gold nano-tip on each electrode; and
(c) attaching each end of a biomolecule having two ends to the gold nano-tips such that one biomolecule bridges over each nanogap in each electrode pair.-
公开(公告)号：EP3948248A1
公开(公告)日：2022-02-09
申请号：EP20776849.0
申请日：2020-03-26
发明人： JIN, Sungho , CHOI, Chulmin , MOLA, Paul
IPC分类号： G01N27/327 , G01N27/30 , C12Q1/6869 , C12Q1/68 , C12Q1/00
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公开(公告)号：EP3882616A1
公开(公告)日：2021-09-22
申请号：EP21160955.7
申请日：2017-02-09
发明人： CHOI, Chulmin , JIN, Sungho , MOLA, Paul, W. , MERRIMAN, Barry L.
IPC分类号： G01N27/327
摘要： A method of manufacturing a device useable in DNA or genome sequencing comprises disposing pairs of electrodes (49) on a substrate, the electrodes within each pair separated by a nanogap; depositing a resist layer (48) over the electrodes (49); patterning the resist layer (48) to create an exposed region (44) on each electrode (49) at or near each nanogap; roughening the electrode surface within each exposed region using various methods; and exposing the exposed regions to biomolecules (42), wherein one biomolecule (42) bridges each nanogap of each electrode pair, with each end of each biomolecule (42) bound to the electrodes (49) at each exposed region (44).
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公开(公告)号：EP3491148A1
公开(公告)日：2019-06-05
申请号：EP17835231.6
申请日：2017-07-26
发明人： JIN, Sungho , MERRIMAN, Barry, L. , GEISER, Tim , CHOI, Chulmin , MOLA, Paul, W.
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9.发明公开
公开(公告)号：EP3408220A1
公开(公告)日：2018-12-05
申请号：EP17745026.9
申请日：2017-01-27
IPC分类号： B82Y15/00 , G01N27/414 , H01L21/764 , H01L29/06 , H01L29/41 , H01L51/10
CPC分类号： H01L29/06 , B82Y15/00 , G01N27/4145 , H01L21/764 , H01L29/41 , H01L51/0093 , H01L51/0558
摘要： In various embodiments of the present disclosure, a molecular electronics sensor array chip comprises: (a) an integrated circuit semiconductor chip; and (b) a plurality of molecular electronic sensor devices disposed thereon, each of said sensor devices comprising: (i) a pair of nanoscale source and drain electrodes separated by a nanogap; (ii) a gate electrode; and (iii) a bridge and/or probe molecule spanning the nanogap and connecting the source and drain electrodes, wherein the molecular electronic sensor devices are organized into an electronically addressable, controllable, and readable array of sensor pixels.
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公开(公告)号：EP3403079A1
公开(公告)日：2018-11-21
申请号：EP16885434.7
申请日：2016-12-28
IPC分类号： G01N27/00
CPC分类号： G01N27/4145
摘要： Electronic sensors configured to detect single molecules and methods of using and manufacturing same are disclosed. A sensor may include source and drain electrodes spaced apart by a sensor gap; a gate electrode, wherein the source, drain and gate electrodes cooperate to form an electrode circuit; and a bridge molecule bridging across the sensor gap, connecting source and drain electrodes; and a probe coupled to the bridge molecule, wherein interaction of the probe with a nucleic acid is detectible by monitoring a parameter of the electrode circuit. In various examples, the nucleic acid comprises DNA or RNA.
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