利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

3 条记录 (耗时 0.009 秒)

    Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
    1.
    发明公开
    Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors 失效
    芳氧基和芳基酰氧基甲基酮作为巯基蛋白酶抑制剂

    公开(公告)号：EP0272671A3

    公开(公告)日：1990-06-13

    申请号：EP87118949.4

    申请日：1987-12-21

    申请人： SANDOZ LTD.

    发明人： Krantz, Alexander ,  Pauls, Heinz W. ,  Smith, Roger A. ,  Spencer, Robin W.

    IPC分类号： C07K5/00 ,  A61K37/64 ,  C07C225/02 ,  A61K31/13

    CPC分类号： C07K5/0812 ,  A61K38/00 ,  C07C271/22 ,  C07K5/06078 ,  C07K5/06165 ,  C07K5/06191 ,  Y02P20/55

    摘要： Thiol protease inhibitors are disclosed having the formula:
    or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:
    n is 0 or 1;
    m is 0, 1 or 2;
    X is H or an N-protecting group;
    each Y is independently an optionally protected α-amino acid residue;
    R is an optionally protected α-amino acid side chain that is H or CH₃ or that is bonded to the α-carbon atom to which it is attached by a methylene, methine or phenyl radical; and
    Rʹ is optionally substituted aryl.

    摘要翻译： 公开了具有下式的硫醇蛋白酶抑制剂：或其光学异构体或其药学上可接受的盐，其中：n是0或1; m是0,1或2; X是H或N-保护基团; 每个Y独立地为任选保护的α-氨基酸残基; R是任选保护的α-氨基酸侧链，它是H或CH 3或与亚甲基，次甲基或苯基连接的α-碳原子键合; 并且R'是任选取代的芳基。

    Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
    2.
    发明公开
    Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors 失效
    芳氧基 - 芳酰氧基甲基 - 酮类硫醇蛋白酶 - Hemmungsstoffe。

    公开(公告)号：EP0272671A2

    公开(公告)日：1988-06-29

    申请号：EP87118949.4

    申请日：1987-12-21

    申请人： SANDOZ LTD.

    发明人： Krantz, Alexander ,  Pauls, Heinz W. ,  Smith, Roger A. ,  Spencer, Robin W.

    IPC分类号： C07K5/00 ,  A61K37/64 ,  C07C225/02 ,  A61K31/13

    CPC分类号： C07K5/0812 ,  A61K38/00 ,  C07C271/22 ,  C07K5/06078 ,  C07K5/06165 ,  C07K5/06191 ,  Y02P20/55

    摘要： Thiol protease inhibitors are disclosed having the formula:
    or an optical isomer thereof, or a pharmaceutically acceptable salt thereof, wherein:
    n is 0 or 1;
    m is 0, 1 or 2;
    X is H or an N-protecting group;
    each Y is independently an optionally protected α-amino acid residue;
    R is an optionally protected α-amino acid side chain that is H or CH₃ or that is bonded to the α-carbon atom to which it is attached by a methylene, methine or phenyl radical; and
    Rʹ is optionally substituted aryl.

    摘要翻译： 公开了具有下式的硫醇蛋白酶抑制剂：其中：n为0或1; m为0,1或2; X是H或N-保护基; 每个Y独立地是任选保护的α-氨基酸残基; R是任选保护的α-氨基酸侧链，其是H或CH 3，或者通过亚甲基，次甲基或苯基与其连接的α-碳原子键合; 且R'为任选取代的芳基。