公开(公告)号：EP1403367A4

公开(公告)日：2005-08-17

申请号：EP02733390

申请日：2002-06-07

申请人： SANKYO CO

发明人： KOISHI RYUTA ,  ANDO YOSUKE ,  ONO MITSURU ,  YASUMO HIROAKI ,  SHIMIZUGAWA TETSUYA ,  YOSHIDA KENICHI ,  SHIMAMURA MITSURU ,  FURUKAWA HIDEHIKO

IPC分类号： C07K14/47 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N15/12 ,  C12P21/08 ,  C12Q1/68 ,  C12N15/09 ,  C07K16/08 ,  C12N5/10 ,  C12P21/02 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/53

CPC分类号： C07K14/47 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

摘要： It is intended to provide a novel method of testing a remedy or a preventive for at least one disease selected from among hyperlipemia, arteriosclerosis and hyperglycemia. More specifically, a method which comprises culturing cultured cells in the presence or absence of a test substance, detecting the mRNA expression dose, promoter activity or protein production level of “angiopoetin−associated protein 3 or 4” gene, and thus selecting a test substance showing a lowered mRNA expression dose, promoter activity or protein production level thus detected in the cells cultured in the presence thereof compared with the cells cultured in the absence thereof.

公开(公告)号：EP1239050A4

公开(公告)日：2004-07-21

申请号：EP00981649

申请日：2000-12-08

申请人： SANKYO CO

发明人： KOISHI RYUTA ,  ANDO YOSUKE ,  ONO MITSURU ,  FURUKAWA HIDEHIKO ,  HORIKOSHI HIROYOSHI ,  FUJIWARA TOSHIHIKO

IPC分类号： A61K38/00 ,  A61P3/06 ,  C07K16/18 ,  C07K16/22 ,  C12N15/12 ,  G01N33/50 ,  G01N33/68 ,  C12Q1/68 ,  A61K48/00 ,  C07K14/47 ,  C12N5/10 ,  C12Q1/02 ,  G01N33/563 ,  G01N33/92

CPC分类号： G01N33/5067 ,  A01K2267/0362 ,  C07K16/18 ,  C07K16/22 ,  C12N2799/022 ,  G01N33/50 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5023 ,  G01N33/6893 ,  G01N2500/20 ,  G01N2800/044

摘要： A novel method of testing a remedy or a preventive for hyperlipemia; and a nucleic acid probe, a primer and an antibody which are employed in this method. More particularly speaking, a method of testing the effect of a test substance as a remedy or a preventive for hyperlipemia by using the expression of a gene represented by SEQ ID NO:1 or 2 in Sequence Listing, which participates in the control of the blood neutral fat level of mammalians, as an indication; and a nucleic acid probe, a primer and an antibody employed in this method. By using this method, candidates for preventives or remedies for hyperlipemia can be searched for.