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公开(公告)号：EP1541571A4
公开(公告)日：2008-12-03
申请号：EP03765317
申请日：2003-07-17
申请人： SANKYO CO
IPC分类号： A61P1/00 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/12 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/04 , A61P25/28 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P37/08 , A61P43/00 , C07D471/04 , A61K31/444
CPC分类号： C07D471/04
摘要： A bicyclic unsaturated tertiary amine compound which can inhibit the production of inflammatory cytokine. It is a compound represented by the following general formula (I), pharmacologically acceptable salt thereof, pharmacologically acceptable ester thereof, or pharmacologically acceptable other derivative thereof: (I) wherein A represents pyrrole or pyrazole; R1 represents optionally substituted aryl or heteroaryl; R2 represents optionally substituted heteroaryl; and R3 represents indolizine.
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公开(公告)号：EP2620434A4
公开(公告)日：2014-07-09
申请号：EP11826892
申请日：2011-09-22
发明人： OHKAWA NOBUYUKI , IIDA KOUKI , NAGASAKI TAKAYOSHI
IPC分类号： C07D317/72 , A61K31/357 , A61P29/00 , A61P31/04 , A61P31/12 , A61P43/00
CPC分类号： C07D317/72 , A61K31/357
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公开(公告)号：EP2862861A4
公开(公告)日：2015-04-22
申请号：EP13804804
申请日：2013-06-13
发明人： KOBAYASHI HIDEKI , OHKAWA NOBUYUKI , TAKANO DAISUKE , KUBOTA HIDEKI , ONODA TOSHIO , KANEKO TOSHIO , ARAI MASAMI , TERASAKA NAOKI
IPC分类号： C07D471/04 , A61K31/4545 , A61K31/4709 , A61K31/497 , A61K31/501 , A61K31/506 , A61P3/06 , A61P9/10 , A61P13/12 , A61P43/00
CPC分类号： C07D471/04 , A61K9/0019 , A61K9/0095 , A61K9/2054 , A61K9/2059 , A61K9/4858 , A61K9/4875
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公开(公告)号：EP1935879A4
公开(公告)日：2011-07-06
申请号：EP06810068
申请日：2006-09-13
IPC分类号： C07C311/14 , A61K31/215 , A61K31/336 , A61K31/343 , A61K31/357 , A61K31/385 , A61K31/39 , A61K31/40 , A61K31/4025 , A61K31/443 , A61K31/5375 , A61P43/00 , C07D207/50 , C07D303/36 , C07D307/94 , C07D311/96 , C07D317/72 , C07D319/08 , C07D327/04 , C07D339/06 , C07D405/12
CPC分类号： C07C311/14 , C07C2601/16 , C07C2602/50 , C07D303/38 , C07D307/94 , C07D317/72 , C07D319/08 , C07D321/10 , C07D327/04 , C07D339/06 , C07D339/08 , C07D493/04 , C07D493/10
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5.发明公开Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses 有权杂芳基取代吡咯，Verfahren zu ihrer Herstellung und ihre therapeutische Anwendung
公开(公告)号：EP1070711A2
公开(公告)日：2001-01-24
申请号：EP00306196
申请日：2000-07-20
申请人： SANKYO CO
发明人： KIMURA TOMIO , AOKI KAZUMASA , NAKAO AKIRA , USHIYAMA SHIGERU , SHIMOZATO TAKAICHI , OHKAWA NOBUYUKI
IPC分类号： A61P9/10 , A61P11/06 , A61P17/06 , A61P29/00 , C07D401/04 , C07D401/14 , C07D451/02 , C07D453/02 , C07D455/02 , C07D471/04 , A61K31/4375 , A61K31/4427
CPC分类号： C07D451/02 , C07D401/04 , C07D401/14 , C07D453/02 , C07D455/02 , C07D471/04
摘要： Compounds of formula (I): wherein: A is a pyrrole ring; R is an optionally substituted aryl or heteroaryl group; R is an optionally substituted nitrogen-containing heteroaryl group; R represents a group of the formula -X-R , wherein X is a single bond or an optionally substituted alkylene, alkenylene or alkynylene group, and R is a substituted cycloalkyl group, a substituted aryl group, a substituted heterocyclyl group, an optionally substituted nitrogen-containing heterocyclyl group, a substituted heteroaryl group, an optionally substituted nitrogen-containing heteroaryl group, or -NR R , wherein each of R and R is a hydrogen atom or an alkyl, alkenyl, alkynyl, aralkyl or alkylsulfonyl group; PROVIDED THAT said substituents R and R are bonded to the two atoms of said pyrrole ring which are adjacent to the atom of the pyrrole ring to which said substituent R is bonded have excellent inhibitory activity against the production of inflammatory cytokines.
摘要翻译： 式（I）化合物：其中：A是吡咯环; R 1是任选取代的芳基或杂芳基; R 2是任选取代的含氮杂芳基; R 3表示式-XR 4的基团，其中X是单键或任选取代的亚烷基，亚烯基或亚炔基，并且R 4是取代的环烷基，取代的芳基， 取代的杂环基，任选取代的含氮杂环基，取代的杂芳基，任选取代的含氮杂芳基或-NRR，其中R和R各自为氢原子或烷基，烯基，炔基，芳烷基 或烷基磺酰基; 提供所述取代基R 1和R 3与所述吡咯环的两个与所述取代基R 2所键合的吡咯环的原子相邻的原子结合的化合物具有优异的抗生产抑制活性 炎性细胞因子。
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