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1.发明公开6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS 有权6-（4-羟基 - 苯基）-3-烷基-1H-吡唑并[3,4-B]吡啶-4-羰基氨基甲酸酯ALS KINASEINHIBITOREN
公开(公告)号：EP2760862A1
公开(公告)日：2014-08-06
申请号：EP12762007.8
申请日：2012-09-25
申请人： SANOFI
发明人： PLETTENBURG, Oliver , SCHOENAU, Christian , LOEHN, Matthias , HACHTEL, Stephanie , PFEIFFER-MAREK, Stefania , MENDEZ-PEREZ, Maria , KANNT, Aimo , DEDIO, Juergen , KOHLMANN, Markus , SCHIFFER, Alexander , BEGIS, Guillaume , DUCLOS, Olivier , JEANNOT, Fréderic
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D495/04 , C07D498/10 , C07D519/00
摘要： The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula (I), in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 and R
7 are defined as indicated below. The compounds of the formula (I) are protein kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.-
2.发明授权6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS 有权6-（4-羟基 - 苯基）-3-烷基-1H-吡唑并[3,4-b]吡啶-4-甲酰胺衍生物作为激酶抑制剂的
公开(公告)号：EP2760862B1
公开(公告)日：2015-10-21
申请号：EP12762007.8
申请日：2012-09-25
申请人： SANOFI
发明人： PLETTENBURG, Oliver , SCHOENAU, Christian , LOEHN, Matthias , HACHTEL, Stephanie , PFEIFFER-MAREK, Stefania , MENDEZ-PEREZ, Maria , KANNT, Aimo , DEDIO, Juergen , KOHLMANN, Markus , SCHIFFER, Alexander , BEGIS, Guillaume , DUCLOS, Olivier , JEANNOT, Fréderic
IPC分类号： A61K31/437 , A61P3/10 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D495/04 , C07D498/10 , C07D519/00
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