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1.发明公开6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS 有权6-（4-羟基 - 苯基）-3-烷基-1H-吡唑并[3,4-B]吡啶-4-羰基氨基甲酸酯ALS KINASEINHIBITOREN
公开(公告)号：EP2760862A1
公开(公告)日：2014-08-06
申请号：EP12762007.8
申请日：2012-09-25
申请人： SANOFI
发明人： PLETTENBURG, Oliver , SCHOENAU, Christian , LOEHN, Matthias , HACHTEL, Stephanie , PFEIFFER-MAREK, Stefania , MENDEZ-PEREZ, Maria , KANNT, Aimo , DEDIO, Juergen , KOHLMANN, Markus , SCHIFFER, Alexander , BEGIS, Guillaume , DUCLOS, Olivier , JEANNOT, Fréderic
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D495/04 , C07D498/10 , C07D519/00
摘要： The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula (I), in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 and R
7 are defined as indicated below. The compounds of the formula (I) are protein kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.-
2.发明授权DÉRIVÉS DE 5-OXO-5,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE COMME INHIBITEURS DE KINASES CAMKII POUR LE TRAITEMENT DE MALADIES CARDIOVASCULAIRES 有权5-氧代-5,8-二氢吡啶并[2,3-D]嘧啶衍生物AS CAMKII-激酶的抑制剂对心血管疾病治疗
公开(公告)号：EP2521726B1
公开(公告)日：2013-12-18
申请号：EP11704258.0
申请日：2011-01-06
申请人： SANOFI
IPC分类号： C07D471/04 , A61K31/519 , A61P9/00
CPC分类号： C07D471/04
摘要： The present invention relates to 5-oxo-5,8-dihydropyrido[2,3-d]pyrimidine derivatives, to their preparation and to their therapeutic use.
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3.发明公开
公开(公告)号：EP4263493A1
公开(公告)日：2023-10-25
申请号：EP21839793.3
申请日：2021-12-16
申请人： Sanofi
发明人： MUELLER, Paul, Justin , AUGER, Florian , BEGIS, Guillaume , FORICHER, Yann , GREBNER, Christoph , HOURCADE, Stephane , MEYFROOT, Stephanie , RUF, Sven , WIRTH, Klaus
IPC分类号： C07C235/40 , C07C237/12 , C07C237/42 , C07C255/60 , C07C311/46 , A61P43/00 , C07D213/40 , C07D235/14 , C07D305/06 , C07D307/33 , C07D307/88 , C07D311/58 , C07D317/40 , C07D407/12
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4.发明授权6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS 有权6-（4-羟基 - 苯基）-3-烷基-1H-吡唑并[3,4-b]吡啶-4-甲酰胺衍生物作为激酶抑制剂的
公开(公告)号：EP2760862B1
公开(公告)日：2015-10-21
申请号：EP12762007.8
申请日：2012-09-25
申请人： SANOFI
发明人： PLETTENBURG, Oliver , SCHOENAU, Christian , LOEHN, Matthias , HACHTEL, Stephanie , PFEIFFER-MAREK, Stefania , MENDEZ-PEREZ, Maria , KANNT, Aimo , DEDIO, Juergen , KOHLMANN, Markus , SCHIFFER, Alexander , BEGIS, Guillaume , DUCLOS, Olivier , JEANNOT, Fréderic
IPC分类号： A61K31/437 , A61P3/10 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D495/04 , C07D498/10 , C07D519/00
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5.发明公开DERIVES DE 5 - OXO -5, 8- DIHYDROPYRIDO [2, 3 - D]PYRIMIDINE COMME INHIBITEURS DE KINASES CAMKII POUR LE TRAITEMENT DE MALADIES CARDIOVASCULAIRES 有权5-氧代-5,8-二氢吡啶并[2,3-D]嘧啶衍生物AS CAMKII-激酶的抑制剂对心血管疾病治疗
公开(公告)号：EP2521726A1
公开(公告)日：2012-11-14
申请号：EP11704258.0
申请日：2011-01-06
申请人： SANOFI
IPC分类号： C07D471/04 , A61K31/519 , A61P9/00
CPC分类号： C07D471/04
摘要： The invention relates to 5-oxo-5, 8-dihydropyrido [2, 3-d] pyrimidine derivatives of the general Formula (I). The invention also relates to the method for preparing same and to therapeutic use thereof.
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