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公开(公告)号：EP1912949A1
公开(公告)日：2008-04-23
申请号：EP06776307.8
申请日：2006-07-20
申请人： Sanofi-Aventis
发明人： PLETTENBURG, Oliver , HOFMEISTER, Armin , KADEREIT, Dieter , BRENDEL, Joachim , LOEHN, Matthias
IPC分类号： C07D217/24 , A61K31/472 , A61P9/12
CPC分类号： C07D217/24 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I’) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
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2.发明公开PIPERIDINYL-SUBSTITUTED ISOQUINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS 有权哌啶基取代的异喹啉酮衍生物作为Rho激酶抑制剂
公开(公告)号：EP1910333A1
公开(公告)日：2008-04-16
申请号：EP06776306.0
申请日：2006-07-20
申请人： Sanofi-Aventis
发明人： PLETTENBURG, Oliver , HOFMEISTER, Armin , KADEREIT, Dieter , BRENDEL, Joachim , LOEHN, Matthias
IPC分类号： C07D401/12 , A61K31/4725 , A61P9/12
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14
摘要： The invention relates to 6-piperidinyl-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I´) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的磷酸化相关的疾病的式（I）的6-哌啶基 - 取代的异喹诺酮衍生物或式（I'）的异喹啉衍生物 肌球蛋白轻链磷酸酶，以及含有这些化合物的组合物。
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3.发明公开6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS 有权6-（4-羟基 - 苯基）-3-烷基-1H-吡唑并[3,4-B]吡啶-4-羰基氨基甲酸酯ALS KINASEINHIBITOREN
公开(公告)号：EP2760862A1
公开(公告)日：2014-08-06
申请号：EP12762007.8
申请日：2012-09-25
申请人： SANOFI
发明人： PLETTENBURG, Oliver , SCHOENAU, Christian , LOEHN, Matthias , HACHTEL, Stephanie , PFEIFFER-MAREK, Stefania , MENDEZ-PEREZ, Maria , KANNT, Aimo , DEDIO, Juergen , KOHLMANN, Markus , SCHIFFER, Alexander , BEGIS, Guillaume , DUCLOS, Olivier , JEANNOT, Fréderic
IPC分类号： C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D495/04 , C07D498/10 , C07D519/00
摘要： The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula (I), in which R
1 , R
2 , R
3 , R
4 , R
5 , R
6 and R
7 are defined as indicated below. The compounds of the formula (I) are protein kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.-
4.发明公开BI-AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINE DERIVATIVES AS RHO KINASE INHIBITORS 有权双环和多环取代的异喹啉和异喹啉衍生物作为Rho激酶抑制剂的
公开(公告)号：EP2303845A2
公开(公告)日：2011-04-06
申请号：EP09768941.8
申请日：2009-06-18
申请人： Sanofi-Aventis
IPC分类号： C07D217/24 , C07D493/08 , C07D495/08 , A61K31/472 , A61P27/00 , A61P9/00 , A61P25/00 , A61P37/00
CPC分类号： C07D217/24 , C07D493/08 , C07D495/08
摘要： The invention relates to bi- and polycyclic substituted isoquinoline and isoquinolinones of the formula (I) wherein R
1 to R
12 are as defined in the application useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.-
5.发明授权HIGH-THROUGHPUT ENZYME-LINKED IMMUNO ABSORBENT ASSAY (ELISA) FOR DETERMINATON OF RHO-KINASE (ROK) ACTIVITY 有权ELISA（酶联免疫吸收剂测定法）HIGH THROUGHPUT FOR Rho激酶（ROK）活性的测定
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6.发明授权6-(4-HYDROXY-PHENYL)-3-ALKYL-1H-PYRAZOLO[3,4-B]PYRIDINE-4-CARBOXYLIC ACID AMIDE DERIVATIVES AS KINASE INHIBITORS 有权6-（4-羟基 - 苯基）-3-烷基-1H-吡唑并[3,4-b]吡啶-4-甲酰胺衍生物作为激酶抑制剂的
公开(公告)号：EP2760862B1
公开(公告)日：2015-10-21
申请号：EP12762007.8
申请日：2012-09-25
申请人： SANOFI
发明人： PLETTENBURG, Oliver , SCHOENAU, Christian , LOEHN, Matthias , HACHTEL, Stephanie , PFEIFFER-MAREK, Stefania , MENDEZ-PEREZ, Maria , KANNT, Aimo , DEDIO, Juergen , KOHLMANN, Markus , SCHIFFER, Alexander , BEGIS, Guillaume , DUCLOS, Olivier , JEANNOT, Fréderic
IPC分类号： A61K31/437 , A61P3/10 , C07D471/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D495/04 , C07D498/10 , C07D519/00
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7.发明公开SUBSTITUTED 6-(4-HYDROXY-PHENYL)-1H-PYRAZOLO[3,4-B]PYRIDINE DERIVATIVES AS KINASE INHIBITORS 有权取代的6-（4-羟基 - 苯基）-1H-吡唑并[3,4-B]吡啶衍生物作为激酶INHIBITORS-
公开(公告)号：EP2847191A1
公开(公告)日：2015-03-18
申请号：EP13723442.3
申请日：2013-04-29
申请人： SANOFI
发明人： HACHTEL, Stephanie , SCHOENAU, Christian , LOEHN, Matthias , PLETTENBURG, Oliver , PFEIFFER-MAREK, Stefania , SCHIFFER, Alexander , GAUL, Holger , KANNT, Aimo , DEDIO, Juergen , DUDDA, Angela
IPC分类号： C07D471/04 , A61K31/437 , A61P25/00 , A61P29/00 , A61P35/00 , A61P9/00 , A61P3/10
CPC分类号： C07D417/04 , C07D471/04
摘要： Substituted 6-(4-Hydroxy-phenyl)-l H-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors The present invention relates to pyrazolo[3,4-b]pyridine compounds of the formula, in which R', R
2 , R
3 , R
4 , R
5 and R
6 are defined as indicated below. The compounds of the formula I are proteine kinase C (PKC) inhibitors, and are useful for the treatment of diseases associated with diabetes and diabetic complications, such as, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy, for example. The invention furthermore relates to the use of compounds of the formula, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.-
公开(公告)号：EP2313374B1
公开(公告)日：2013-09-18
申请号：EP09768948.3
申请日：2009-06-19
申请人： SANOFI
IPC分类号： C07D217/24 , C07D217/02 , C07D217/22 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/472 , A61K31/4725 , A61P9/12 , A61P43/00
CPC分类号： C07D417/12 , C07D217/02 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12
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9.发明授权CYCLOHEXYLAMIN ISOQUINOLONE DERIVATIVES AS RHO-KINASE INHIBITORS 有权CYOOHEXYLAMIN ISOQUINOLONE DERIVATIVES RHO-KINASE INHIBITORS
公开(公告)号：EP1912949B1
公开(公告)日：2011-08-24
申请号：EP06776307.8
申请日：2006-07-20
申请人： SANOFI
发明人： PLETTENBURG, Oliver , HOFMEISTER, Armin , KADEREIT, Dieter , BRENDEL, Joachim , LOEHN, Matthias
IPC分类号： C07D217/24 , A61K31/472 , A61P9/12
CPC分类号： C07D217/24 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The invention relates to 6-cyclohexylamine-substituted isoquinolone derivatives of the formula (I) or isoquinoline derivatives of the formula (I’) useful for the treatment and/or prevention of diseases associated with Rho-kinase and/or Rho-kinase mediated phosphorylation of myosin light chain phosphatase, and compositions containing such compounds.
摘要翻译： 本发明涉及用于治疗和/或预防与Rho-激酶和/或Rho-激酶介导的磷酸化相关的疾病的式（I）的6-环己胺取代的异喹诺酮衍生物或式（I'）的异喹啉衍生物 肌球蛋白轻链磷酸酶，以及含有这些化合物的组合物。
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10.发明公开HIGH-THROUGHPUT ENZYME-LINKED IMMUNO ABSORBENT ASSAY (ELISA) FOR DETERMINATON OF RHO-KINASE (ROK) ACTIVITY 有权ELISA（酶联免疫吸收剂测定法）HIGH THROUGHPUT FOR Rho激酶（ROK）活性的测定
公开(公告)号：EP1828406A2
公开(公告)日：2007-09-05
申请号：EP05817076.2
申请日：2005-12-07
CPC分类号： C12Q1/485
摘要： The invention is referring to an assay for measuring the activity of a ROK (Rho Kinase) protein by means of a biotinylated peptide.
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