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公开(公告)号：EP1828228A1
公开(公告)日：2007-09-05
申请号：EP05819403.6
申请日：2005-12-13
CPC分类号： C07K7/56
摘要： The invention relates to an improved method for the enzymatic deacylation of lipopeptides to the corresponding nucleus by separating the lateral fatty acid chain of the lipopeptide.
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2.发明公开VERFAHREN ZUR AMIDIERUNG VON POLYPEPTIDEN MIT C-TERMINALEN BASISCHEN AMINOSÄUREN UNTER VERWENDUNG SPEZIFISCHER ENDOPROTEASEN 有权方法酰胺化多肽具有C-末端碱性氨基酸使用特定的内切蛋白酶
公开(公告)号：EP1931705A2
公开(公告)日：2008-06-18
申请号：EP06792022.3
申请日：2006-09-13
发明人： RISSOM, Sebastian , HABERMANN,Paul , SALAGNAD, Christophe , ZOCHER, Frank , LANDRIC-BURTAIN, Laure
IPC分类号： C07K14/575 , C07K14/605 , C12P21/02 , C12P21/06
CPC分类号： C07K1/00 , A61K38/00 , A61K38/16 , C07K14/57563 , C07K14/605 , C12P21/02 , Y02A50/473 , Y02A50/481
摘要： The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.
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3.发明公开
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公开(公告)号：EP1828228B1
公开(公告)日：2008-05-07
申请号：EP05819403.6
申请日：2005-12-13
CPC分类号： C07K7/56
摘要： The invention relates to an improved method for the enzymatic deacylation of lipopeptides to the corresponding nucleus by separating the lateral fatty acid chain of the lipopeptide.
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公开(公告)号：EP3957739A1
公开(公告)日：2022-02-23
申请号：EP21193737.0
申请日：2015-10-29
申请人： SANOFI
发明人： LATTEMANN, Claus , STILLGER, Thomas , JANOCHA, Bernd , RASSER, Hans-Falk , RISSOM, Sebastian , ANDERKO, Simone , BERNHARDT, Rita , HANNEMANN, Frank
IPC分类号： C12P33/06 , C07K14/245 , C12N9/02 , C12N15/52
摘要： Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.
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公开(公告)号：EP3212800A1
公开(公告)日：2017-09-06
申请号：EP15787993.3
申请日：2015-10-29
申请人： SANOFI
发明人： LATTEMANN, Claus , STILLGER, Thomas , JANOCHA, Bernd , RASSER, Hans-Falk , RISSOM, Sebastian , ANDERKO, Simone , BERNHARDT, Rita , HANNEMANN, Frank
IPC分类号： C12P33/06
CPC分类号： C12P33/06
摘要： Generally, the present invention relates to the field of steroid hydroxylation. More specifically, the present invention relates to a method for the 21-hydroxylation of steroids in cells. It also relates to cells expressing a steroid 21-hydroxylating enzyme or steroid 21-hydroxylase, expression vectors comprising a nucleic acid encoding for a steroid 21-hydroxylase and a kit for carrying out the method for the 21-hydroxylation of steroids in cells.
摘要翻译： 通常，本发明涉及类固醇羟基化领域。 更具体地说，本发明涉及细胞中类固醇的21-羟基化的方法。 本发明还涉及表达类固醇21-羟化酶或类固醇21-羟化酶的细胞，包含编码类固醇21-羟化酶的核酸的表达载体和用于实施细胞中类固醇21-羟化的方法的试剂盒。
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7.发明授权VERFAHREN ZUR AMIDIERUNG VON POLYPEPTIDEN MIT C-TERMINALEN BASISCHEN AMINOSÄUREN UNTER VERWENDUNG SPEZIFISCHER ENDOPROTEASEN 有权方法酰胺化多肽具有C-末端碱性氨基酸使用特定的内切蛋白酶
公开(公告)号：EP1931705B1
公开(公告)日：2011-09-07
申请号：EP06792022.3
申请日：2006-09-13
发明人： RISSOM, Sebastian , HABERMANN,Paul , SALAGNAD, Christophe , ZOCHER, Frank , LANDRIC-BURTAIN, Laure
IPC分类号： C07K14/575 , C07K14/605 , C12P21/02 , C12P21/06
CPC分类号： C07K1/00 , A61K38/00 , A61K38/16 , C07K14/57563 , C07K14/605 , C12P21/02 , Y02A50/473 , Y02A50/481
摘要： The invention relates to a method for producing C-terminal amidated dibasic or polybasic peptides, consisting in reacting two peptides in the presence of trypsin biologically active enzymes and, if necessary, in purifying the thus obtainable compounds of formula (I) by means of protein chemistry.
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