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1.发明授权DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION 有权抗体结合带双可变区相关蛋白及结合区域交叉对准
公开(公告)号：EP2691416B1
公开(公告)日：2016-05-18
申请号：EP12716818.5
申请日：2012-03-28
申请人： SANOFI
发明人： BAURIN, Nicolas , BEIL, Christian , CORVEY, Carsten , LANGE, Christian , LI, Danxi , MIKOL, Vincent , STEINMETZ, Anke , RAO, Ercole
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.
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公开(公告)号：EP4408988A1
公开(公告)日：2024-08-07
申请号：EP22800601.1
申请日：2022-09-29
申请人： Sanofi
CPC分类号： C12N9/13 , C12Y208/02001 , C12P11/00 , C12P19/26
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3.发明授权NOUVEAUX DERIVES IMIDAZOLONES, LEUR PREPARATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES, UTILISATION COMME INHIBITEURS DE PROTEINES KINASES NOTAMMENT CDC7 有权新的咪唑啉衍生物积极的准备，其药物组合物及其作为蛋白激酶抑制剂，特别是CDC7
公开(公告)号：EP2094699B1
公开(公告)日：2011-07-20
申请号：EP07858418.2
申请日：2007-10-10
申请人： Sanofi-Aventis
发明人： LEROY, Vincent , BACQUE, Eric , CONSEILLER, Emmanuel , STEINMETZ, Anke , RONAN, Baptiste , LETALLEC, Jean-Philippe
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to products of the formula (I) in which : X-Y is NH-C(S), N=C-NR7R8, N=C-SR, N=C-R or N=C-OR; R and R1 are H or optionally substituted cycloalkyl, alkyl, heterocycloalkyl, aryl or heteroaryl,; R2 is H, Hal or alkyl; R3 is H, Hal, OH, alkyl or alkoxy; R4 is H, Hal, CN or alkyl; R5 is essentially H, Hal, OH, NR7R8, cycloalkyl, alkyl, alkoxy, heterocycloalkyl, aryl or heteroaryl, optionally substituted; R6 is H, Hal, OH, NH2, NHalk, N(alk)2, alkyl or alkoxy; with R7 et R8 being such that one is H or optionally substituted alk, while the other is H or optionally substituted cycloalkyl, alkyl, heterocycloalkyl, heteroaryl or aryl; or with R7 and R8 forming together with N an optionally substituted cyclic radical optionally containing O, S or N. The invention also relates to isomers and salts thereof used as drugs and essentially as protein kinase inhibitors, in particular CDC7.
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公开(公告)号：EP4408987A2
公开(公告)日：2024-08-07
申请号：EP22798260.0
申请日：2022-09-29
申请人： Sanofi
CPC分类号： C12N9/13 , C12Y208/02001 , C12N15/52
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5.发明公开DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION 审中-公开抗体结合带双可变区相关蛋白及结合区域交叉对准
公开(公告)号：EP3112380A1
公开(公告)日：2017-01-04
申请号：EP16169620.8
申请日：2012-03-28
申请人： SANOFI
发明人： BAURIN, Nicolas , BEIL, Christian , CORVEY, Carsten , LANGE, Christian , LI, Danxi , MIKOL, Vincent , STEINMETZ, Anke , RAO, Ercole
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.
摘要翻译： 本发明提供了抗体样结合蛋白包含四个多肽链没有形成四个抗原结合位点，worin每对多肽形成抗体样结合蛋白的具有具有交叉定向双重可变结构域。 因此本发明提供用于制备抗原搜索样结合蛋白的方法。
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6.发明公开NOUVEAUX DERIVES IMIDAZOLONES, LEUR PREPARATION A TITRE DE MEDICAMENTS, COMPOSITIONS PHARMACEUTIQUES, UTILISATION COMME INHIBITEURS DE PROTEINES KINASES NOTAMMENT CDC7 有权新的咪唑啉衍生物积极的准备，其药物组合物及其作为蛋白激酶抑制剂，特别是CDC7
公开(公告)号：EP2094699A2
公开(公告)日：2009-09-02
申请号：EP07858418.2
申请日：2007-10-10
申请人： Sanofi-Aventis
发明人： LEROY, Vincent , BACQUE, Eric , CONSEILLER, Emmanuel , STEINMETZ, Anke , RONAN, Baptiste , LETALLEC, Jean-Philippe
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to products of the formula (I) in which : X-Y is NH-C(S), N=C-NR7R8, N=C-SR, N=C-R or N=C-OR; R and R1 are H or optionally substituted cycloalkyl, alkyl, heterocycloalkyl, aryl or heteroaryl,; R2 is H, Hal or alkyl; R3 is H, Hal, OH, alkyl or alkoxy; R4 is H, Hal, CN or alkyl; R5 is essentially H, Hal, OH, NR7R8, cycloalkyl, alkyl, alkoxy, heterocycloalkyl, aryl or heteroaryl, optionally substituted; R6 is H, Hal, OH, NH2, NHalk, N(alk)2, alkyl or alkoxy; with R7 et R8 being such that one is H or optionally substituted alk, while the other is H or optionally substituted cycloalkyl, alkyl, heterocycloalkyl, heteroaryl or aryl; or with R7 and R8 forming together with N an optionally substituted cyclic radical optionally containing O, S or N. The invention also relates to isomers and salts thereof used as drugs and essentially as protein kinase inhibitors, in particular CDC7.
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7.发明公开DUAL VARIABLE REGION ANTIBODY-LIKE BINDING PROTEINS HAVING CROSS-OVER BINDING REGION ORIENTATION 有权抗体结合带双可变区相关蛋白及结合区域交叉对准
公开(公告)号：EP2691416A1
公开(公告)日：2014-02-05
申请号：EP12716818.5
申请日：2012-03-28
申请人： SANOFI
发明人： BAURIN, Nicolas , BEIL, Christian , CORVEY, Carsten , LANGE, Christian , LI, Danxi , MIKOL, Vincent , STEINMETZ, Anke , RAO, Ercole
CPC分类号： C07K16/46 , C07K16/00 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2866 , C07K16/32 , C07K16/461 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/55 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2318/00
摘要： The invention provides antibody-like binding proteins comprising four polypeptide chains that form four antigen binding sites, wherein each pair of polypeptides forming an antibody-like binding protein possesses dual variable domains having a crossover orientation. The invention also provides methods for making such antigen-like binding proteins.
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