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    CELL ADHESIVE MATERIAL FOR BIOLOGICAL TISSUE
    1.
    发明公开
    CELL ADHESIVE MATERIAL FOR BIOLOGICAL TISSUE 审中-公开
    生物组织细胞粘附材料

    公开(公告)号：EP2636415A4

    公开(公告)日：2015-03-25

    申请号：EP11838001

    申请日：2011-11-01

    申请人： SANYO CHEMICAL IND LTD ,  TABATA YASUHIKO

    发明人： TABATA YASUHIKO ,  KAWABATA SHINGO

    IPC分类号： A61L27/00

    CPC分类号： A61L27/22 ,  A61L27/227 ,  A61L27/3804 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2420/02

    摘要： An object of the present invention is to provide a cell-adhesive material for biological tissues, in which the surface of a material for biological tissues (particularly metallic material) is modified strongly with a large amount of a cell-adhesive artificial peptide (P) that retains a biological activity. The present invention provides a cell-adhesive material for biological tissues including a cell-adhesive artificial peptide (P) and a material for biological tissues, wherein the cell-adhesive artificial peptide (P) is immobilized on the surface of the material for biological tissues through an electrochemical reaction. The cell-adhesive artificial peptide (P) is preferably a peptide (P1) that is synthesized by a genetic recombinant microorganism and has at least one cell-adhesive minimal amino acid sequence (X) in one molecule. The number of the cell-adhesive minimal amino acid sequences (X) in one molecule of the polypeptide (P1) is preferably 3 to 50.

    WOUND HEALING AGENT
    2.
    发明公开
    WOUND HEALING AGENT 审中-公开
    的主动伤口愈合

    公开(公告)号：EP2959912A4

    公开(公告)日：2016-11-30

    申请号：EP14754619

    申请日：2014-02-20

    申请人： SANYO CHEMICAL IND LTD

    发明人： KAWABATA SHINGO

    IPC分类号： A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61P17/02 ,  A61P43/00 ,  C07K14/00

    CPC分类号： A61K38/08 ,  A61K38/10 ,  C07K14/00

    摘要： The present invention aims to provide a wound healing agent that inhibits bacterial growth, promotes granulation tissue formation and epithelization, and minimizes foreign body reaction in the granulation tissue. The wound healing agent of the present invention contains protein (A) and water, wherein the protein (A) contains: GAGAGS (1); and an amino acid sequence (X) and/or an amino acid sequence (X'), and the total percentage of ² turns and random coils in the protein (A) as determined by circular dichroism spectroscopy is 60 to 85%, and the percentage of the total number of amino acid residues in the amino acid sequences (X) and (X') is 50 to 70% of the total number of amino acid residues in the protein (A). Amino acid sequence (X): at least one amino acid sequence selected from the group consisting of VPGVG (2), GVGVP (3), and GAHGPAGPK (4). Amino acid sequence (X'): an amino acid sequence in which 1 or 2 amino acid residues in the amino acid sequence (X) are independently replaced by a lysine (K) or arginine (R) residue.