公开(公告)号：EP3328345A1

公开(公告)日：2018-06-06

申请号：EP16831029.0

申请日：2016-07-14

申请人： ELC Management LLC

发明人： CARULLO, Anne ,  PALMER QUINTANO, Jennifer ,  KASSOUF, Joyce ,  PERNODET, Nadine ,  COLLINS, Donald ,  LAYMAN, Dawn ,  HAFKIN, Allan ,  FONTANET, Osvaldo

IPC分类号： A61K8/02 ,  A61K8/362 ,  A61K8/97 ,  A61K8/64 ,  A45D44/00 ,  A45D44/22 ,  A61Q19/00

CPC分类号： A45D44/002 ,  A45D44/22 ,  A61K8/0212 ,  A61K8/36 ,  A61K8/64 ,  A61K9/70 ,  A61K9/7007 ,  A61K9/7023 ,  A61K36/18 ,  A61K36/28 ,  A61L15/44 ,  A61L2300/25 ,  A61Q19/08

摘要： A sheet pack comprising an absorbent layer impregnated with a treatment composition containing at least one ingredient that when topically applied to skin stimulates a gene that is variably expressed over a 24 hour period in native untreated skin cells; the sheet pack contained in a package with user instructions to topically apply the sheet pack to the skin at a time when the gene that is stimulated by the ingredient is being maximally expressed in native untreated skin cells; and methods for treating skin and methods for making a sheet pack.

公开(公告)号：EP1675618B1

公开(公告)日：2018-05-09

申请号：EP04795954.9

申请日：2004-10-21

申请人： Allvivo, Inc.

发明人： NEFF, Jennifer, A. ,  CALDWELL, Karin, D. ,  ANDERSSON, Jonas ,  NILSSON, Bo ,  NILSSON-EKDAHL, Kristina

IPC分类号： A61L27/34 ,  A61L27/54 ,  A61K47/60 ,  A61K47/56

CPC分类号： A61L27/54 ,  A61K47/56 ,  A61K47/60 ,  A61L27/34 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/258 ,  A61L2300/604 ,  C08L71/02

摘要： Elutable coatings comprising protein resistant components and bioactive agent on medical devices are disclosed. The elutable coatings comprise labile linkers that can be cleaved under controlled conditions.

公开(公告)号：EP3294352A1

公开(公告)日：2018-03-21

申请号：EP16723466

申请日：2016-05-11

申请人： HAEMOSTATIX LTD

发明人： ZBOZIEN RENATA ,  NICHOLS BEN

IPC分类号： A61L15/28 ,  A61L15/32 ,  A61L15/44 ,  C07K17/06

CPC分类号： A61L15/28 ,  A61L15/32 ,  A61L15/44 ,  A61L2300/232 ,  A61L2300/25 ,  A61L2300/418 ,  A61L2400/04 ,  C07K17/12 ,  C08L1/04

摘要： Haemostatic materials are described, particularly haemostatic materials comprising an oxidised cellulose substrate covalently immobilised to a plurality of fibrinogen-binding peptides. Methods are described for covalently attaching fibrinogen binding peptides to oxidised cellulose substrates ad other substrates that have carboxyl groups on their surface.

公开(公告)号：EP2176420B1

公开(公告)日：2018-02-14

申请号：EP08772520.6

申请日：2008-07-11

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： MIETZNER, Timothy A. ,  MONTELARO, Ronald C.

IPC分类号： C12Q1/68 ,  C07K14/00 ,  C07K14/16

CPC分类号： A61L29/085 ,  A61K38/08 ,  A61K38/10 ,  A61K38/162 ,  A61L27/34 ,  A61L27/54 ,  A61L29/16 ,  A61L2300/25 ,  A61L2300/404 ,  C07K14/005 ,  C07K2319/10 ,  C12N2740/16022 ,  C12N2740/16033 ,  C12N2740/16122 ,  C12N2760/16134 ,  C08L89/00

摘要： Described herein are peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides, designated LBU, WLBU and WR, are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The antimicrobial peptides are monomers or multimers of peptides referred to as the Lytic Base Unit (LBU) peptides, derived from the LLP1 analogs and also having antimicrobial activity. Also described herein are using the peptides in a variety of contexts, including the treatment or prevention of infectious diseases. Methods of killing fungi, such as Candida and Cryptococcus species, and bacteria, such as B. anthracis, are provided herein. Methods of neutralizing enveloped viruses, such as poxvirus, herpesvirus, rhabdovirus, hepadnavirus, baculovirus, orthomyxovirus, paramyxovirus, retrovirus, togavirus, bunyavirus and flavivirus, including influenza virus and HIV-1 also are provided herein. Solid phase substrates and peptide-cargo complexes comprising the peptides also are provided.

公开(公告)号：EP3110835A1

公开(公告)日：2017-01-04

申请号：EP15708869.1

申请日：2015-02-25

申请人： The University Of Birmingham ,  The Secretary of State of Defence of The United Kingdom of Great Britain and Northern Ireland

发明人： STAMBOULIS, Artemis ,  DE COGAN, Felicity Jane ,  SCOTT, Robert ,  PEACOCK, Anna Frances Acushla

IPC分类号： C07K14/47 ,  C07K17/14 ,  C12N15/62 ,  A61L27/54

CPC分类号： C07K7/08 ,  A01N25/08 ,  A01N47/44 ,  A61L27/54 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/02 ,  C07K14/001 ,  C07K14/4723 ,  C07K17/08 ,  C07K17/14 ,  C07K2319/20

摘要： The invention relates to an antimicrobial surface, in particular a surface functionalised with a peptide comprising an antimicrobial moiety. The invention comprises a surface functionalised with a peptide comprising an antimicrobial moiety and a binder moiety, wherein the peptide is immobilized on the surface by electrostatic interactions between the binder moiety and the surface. Further provided is a medical device, a peptide and a method for the immobilization of a peptide.

摘要翻译： 本发明涉及抗微生物表面，特别是用包含抗微生物部分的肽官能化的表面。 本发明包括用包含抗微生物部分和粘合剂部分的肽官能化的表面，其中通过粘合剂部分和表面之间的静电相互作用将肽固定在表面上。 还提供了用于固定肽的医疗装置，肽和方法。

公开(公告)号：EP2983725A4

公开(公告)日：2016-12-21

申请号：EP14782741

申请日：2014-04-07

申请人： INOSSIA AB

发明人： PERSSON CECILIA ,  LOPEZ ALEJANDRO

IPC分类号： A61L24/06 ,  A61L27/26 ,  A61L27/44 ,  C08L23/00

CPC分类号： A61L24/06 ,  A61L24/001 ,  A61L24/0015 ,  A61L27/16 ,  A61L27/50 ,  A61L2300/25 ,  A61L2300/406 ,  A61L2400/06 ,  A61L2430/02 ,  C08L33/12

摘要： The embodiments relate to an injectable composition for a bone cement material comprising a dry powder component, a liquid component and a modifier configured to modify a Young's modulus of the bone cement material. The modifier is linoleic acid or a derivative thereof and is present in a concentration of 0.1 to 12 v/v of the liquid component.

摘要翻译： 实施方案涉及用于骨水泥材料的可注射组合物，其包含干粉组分，液体组分和修饰剂，其被配置为改变骨水泥材料的杨氏模量。 改性剂是亚油酸或其衍生物，并且以0.1至12v / v的液体组分的浓度存在。

公开(公告)号：EP2921148A4

公开(公告)日：2015-11-25

申请号：EP13854481

申请日：2013-11-08

申请人： CONSEJO SUPERIOR INVESTIGACION ,  FUNDACION RIOJA SALUD ,  UNIV DE ALCALÁ DE HENARES

发明人： REYES ORTEGA FELISA ,  RODRÍGUEZ CRESPO GEMA ,  AGUILAR DE ARMAS MARÍA ROSA ,  GONZÁLEZ GÓMEZ ÁLVARO ,  SAN ROMÁN DEL BARRIO JULIO ,  SOLIS CORREA RAÚL ENRIQUE ,  GARCÍA HONDUVILLA NATALIO ,  BUJÁN VARELA JULIA ,  CIFUENTES NEGRETE ALBERTO ,  MARTÍNEZ RAMÍREZ ALFREDO ,  GARCÍA SANMARTÍN MIREN JOSUNE ,  STENZEL MARTINA

IPC分类号： A61F13/02 ,  A61L15/22 ,  A61L15/44 ,  A61L15/60

CPC分类号： A61L15/64 ,  A61F13/00017 ,  A61F13/00029 ,  A61F13/00063 ,  A61F2013/00221 ,  A61F2013/00582 ,  A61F2013/00646 ,  A61F2013/00906 ,  A61F2013/00927 ,  A61F2013/00982 ,  A61K9/5138 ,  A61K9/5153 ,  A61K9/7092 ,  A61K31/727 ,  A61K38/22 ,  A61L15/225 ,  A61L15/24 ,  A61L15/26 ,  A61L15/28 ,  A61L15/325 ,  A61L15/44 ,  A61L15/60 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/45 ,  A61L2300/602 ,  A61L2300/624 ,  A61L2400/12 ,  A61L2430/34 ,  C08L75/04

公开(公告)号：EP2897656A1

公开(公告)日：2015-07-29

申请号：EP13766000.7

申请日：2013-09-18

申请人： Corticalis AS

发明人： LYNGSTADAAS, Petter, S. ,  HAUGEN, Håvard, J. ,  TIAINEN, Hanna

IPC分类号： A61L27/06 ,  A61L27/10 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56

CPC分类号： A61L27/34 ,  A61L27/06 ,  A61L27/10 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/425 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/25 ,  A61L2300/412 ,  A61L2300/422 ,  A61L2300/64 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2420/04 ,  A61L2420/06 ,  A61L2430/02 ,  A61L2430/12

摘要： The present document is directed to a titanium dioxide scaffold comprising a hydrogel coating comprising a biologically active substance. Also disclosed is a method for producing a thin hydrogel coating on a titanium dioxide scaffold and uses of the hydrogel coated scaffolds as medical implants.

公开(公告)号：EP2855507A1

公开(公告)日：2015-04-08

申请号：EP13737423.7

申请日：2013-06-03

申请人： Ben-Gurion University of The Negev Research and Development Authority

发明人： RAPAPORT, Hanna ,  GITTELMAN, Anna

IPC分类号： C07K7/08 ,  A61L27/06 ,  A61C8/00

CPC分类号： A61L27/54 ,  A61C8/0012 ,  A61K38/02 ,  A61L27/06 ,  A61L27/30 ,  A61L27/34 ,  A61L31/00 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/606 ,  A61L2430/12 ,  A61L2430/24 ,  B82Y30/00 ,  C01G23/043 ,  C07K5/1013 ,  C07K7/06 ,  C07K7/08 ,  G01N33/54393 ,  C08L89/00

摘要： Use of the peptides and titanium devices comprising same are also disclosed.

摘要翻译： 公开了一种分离的肽。 肽包含经由β片断连接体与异源生物活性氨基酸序列连接的氧化钛结合氨基酸序列，其中：（i）选择氧化钛结合氨基酸序列与氧化钛协同结合; （ii）选择氧化钛结合氨基酸序列以诱导β片结构; 和（ii）氧化钛结合氨基酸序列以比所述生物活性氨基酸序列更高的亲和力结合氧化钛，在生理条件下与氧化钛结合。 还公开了包含其的肽和钛装置的用途。

公开(公告)号：EP2578245A3

公开(公告)日：2015-01-21

申请号：EP12182662.2

申请日：2012-08-31

申请人： Covidien LP

发明人： Hodgkinson, Gerald ,  Hadba, Ahmad Robert

IPC分类号： A61L27/04 ,  A61L27/34 ,  A61L31/02 ,  A61L31/10 ,  A61L27/54 ,  A61L31/16

CPC分类号： A61L27/34 ,  A61L27/047 ,  A61L27/54 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25

摘要： A surgical implant is provided which includes a body and a coating in contact with at least a portion of the body, the body including metallic magnesium, the coating including a hydrogel having an adhesion peptide contained therein. The adhesion peptide may be derived from an extracellular matrix protein and may be covalently bonded to the hydrogel. A method of making a surgical implant includes providing a magnesium based degradable implant body; applying and adhering a functionalized reactive silane based adhesion promoting layer to the implant body; providing a hydrogel monomeric solution having extracellular matrix adhesion peptides incorporated therein; and contacting the hydrogel monomeric solution with the adhesion promoting layer such that the hydrogel polymerizes and bonds to the adhesion promoting layer and encapsulates at least a portion of the implant.