公开(公告)号：EP2676683A4

公开(公告)日：2015-01-14

申请号：EP12747857

申请日：2012-02-01

申请人： UNIV KYOTO ,  SANYO CHEMICAL IND LTD

发明人： SUZUKI SHIGEHIKO ,  KAWAI KATSUYA ,  KAWABATA SHINGO

IPC分类号： A61L27/00 ,  C07K5/083 ,  C07K7/06 ,  C07K14/00 ,  C12N15/09

CPC分类号： C07K14/78 ,  A61K38/00 ,  A61L26/0028 ,  A61L26/008 ,  A61L27/227 ,  C07K5/0806

公开(公告)号：EP2959912A4

公开(公告)日：2016-11-30

申请号：EP14754619

申请日：2014-02-20

申请人： SANYO CHEMICAL IND LTD

发明人： KAWABATA SHINGO

IPC分类号： A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61P17/02 ,  A61P43/00 ,  C07K14/00

CPC分类号： A61K38/08 ,  A61K38/10 ,  C07K14/00

摘要： The present invention aims to provide a wound healing agent that inhibits bacterial growth, promotes granulation tissue formation and epithelization, and minimizes foreign body reaction in the granulation tissue. The wound healing agent of the present invention contains protein (A) and water, wherein the protein (A) contains: GAGAGS (1); and an amino acid sequence (X) and/or an amino acid sequence (X'), and the total percentage of ² turns and random coils in the protein (A) as determined by circular dichroism spectroscopy is 60 to 85%, and the percentage of the total number of amino acid residues in the amino acid sequences (X) and (X') is 50 to 70% of the total number of amino acid residues in the protein (A). Amino acid sequence (X): at least one amino acid sequence selected from the group consisting of VPGVG (2), GVGVP (3), and GAHGPAGPK (4). Amino acid sequence (X'): an amino acid sequence in which 1 or 2 amino acid residues in the amino acid sequence (X) are independently replaced by a lysine (K) or arginine (R) residue.

公开(公告)号：EP2636415A4

公开(公告)日：2015-03-25

申请号：EP11838001

申请日：2011-11-01

申请人： SANYO CHEMICAL IND LTD ,  TABATA YASUHIKO

发明人： TABATA YASUHIKO ,  KAWABATA SHINGO

IPC分类号： A61L27/00

CPC分类号： A61L27/22 ,  A61L27/227 ,  A61L27/3804 ,  A61L27/54 ,  A61L2300/25 ,  A61L2300/252 ,  A61L2420/02

摘要： An object of the present invention is to provide a cell-adhesive material for biological tissues, in which the surface of a material for biological tissues (particularly metallic material) is modified strongly with a large amount of a cell-adhesive artificial peptide (P) that retains a biological activity. The present invention provides a cell-adhesive material for biological tissues including a cell-adhesive artificial peptide (P) and a material for biological tissues, wherein the cell-adhesive artificial peptide (P) is immobilized on the surface of the material for biological tissues through an electrochemical reaction. The cell-adhesive artificial peptide (P) is preferably a peptide (P1) that is synthesized by a genetic recombinant microorganism and has at least one cell-adhesive minimal amino acid sequence (X) in one molecule. The number of the cell-adhesive minimal amino acid sequences (X) in one molecule of the polypeptide (P1) is preferably 3 to 50.