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1.发明公开USE OF NITRIC OXIDE DONORS OR NITRIC OXIDE INHIBITORS FOR REGULATING CERVICAL DILATATION AND EXTENSIBILITY 无效USE STICKSTOFFOXYDDONOREN或拮抗剂的调颈椎应变
公开(公告)号：EP0814785A1
公开(公告)日：1998-01-07
申请号：EP96909707.0
申请日：1996-03-14
CPC分类号： A61K45/06 , A61K31/04 , A61K31/198 , A61K31/21 , A61K31/223 , A61K31/295 , A61K31/34
摘要： The invention describes the regulation of cervical dilatation and extensibility by the use of nitric oxide donors and/or substrates or nitric oxide inhibitors. There can be used either (a) at least one nitric oxide donor and/or substrate for manufacture of a medicament to be administered locally intracervically or intravaginally for induction of cervical ripening or (b) at least one nitric oxide inhibitor for manufacture of a medicament to be administered locally intracervically or intravaginally for treatment of cervical insufficiency or preterm labor.
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2.发明公开PROGESTERONANTAGONISTISCH- UND ANTIÖSTROGEN WIRKSAME VERBINDUNGEN ZUR GEMEINSAMEN VERWENDUNG FÜR DIE WEIBLICHE KONTRAZEPTION 失效PROGESTERONANTAGONISTISCH-和抗雌激素活性的化合物为女性避孕的使用
公开(公告)号：EP0799042A1
公开(公告)日：1997-10-08
申请号：EP95943194.0
申请日：1995-12-23
CPC分类号： A61K31/567 , A61K31/138 , A61K2300/00
摘要： The invention concerns the use of at least one compound with progesterone-antagonistic properties and at least one compound with anti-oestrogen properties, each in a dose which would not in itself inhibit ovulation, in a single dosing unit, in order to prepare medicaments for female contraception.
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3.发明公开TREATMENT OF UTERINE CONTRACTILITY DISORDERS WITH A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR, OR A NITRIC OXIDE INHIBITOR 失效处理与及其一氧化氮合酶底物和/或捐助，或STICKSTOFFOXIDHEMMER子宫收缩的申诉
公开(公告)号：EP0730448A1
公开(公告)日：1996-09-11
申请号：EP95900759.0
申请日：1994-11-17
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/557 , A61K31/57 , A61K38/11 , A61K31/41 , A61K31/34 , A61K31/295 , A61K31/21 , A61K2300/00
摘要： Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in combination with one or more of a prostaglandin inhibitor, a prostacyclin-mimetic, a progestin, an oxytocin antagonist or a β-agonist in an amount effective to ameliorate the symptoms thereof; and inadequate menses treated and induction of abortion or stimulation of labor in a pregnant female is achieved by uterine contractility stimulation by administering thereto a nitric oxide inhibitor, either alone or in a combination of progesterone antagonist, an oxytocin or oxytocin analogue antagonist or prostaglandin.
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4.发明公开COMBINATION OF A PROGESTATIONAL AGENT AND A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR FOR THE TREATMENT OF PREECLAMPSIA AND PRETERM LABOR 失效组合物先兆子痫和早期出生到PROGESTATIVES剂处理和氮氧化物合酶衬底和/或供体CONTAINS
公开(公告)号：EP0708647A1
公开(公告)日：1996-05-01
申请号：EP94924261.0
申请日：1994-07-18
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/341 , A61K31/57 , A61K31/60 , Y10S514/841 , Y10S514/843 , Y10S514/866 , Y10S514/903 , A61K31/557 , A61K31/34 , A61K31/26 , A61K31/21 , A61K2300/00
摘要： Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI2-mimetic, a thromboxane (TXA2) inhibitor, a compound possessing TXA2-agonistic and TXA2-inhibiting properties, a compound possessing TXA2-antagonistic and PGI2-memetic activities, and a TXA2 antagonist.
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5.发明授权KOMBINATIONSPRODUKT ZUR KONTRAZEPTION ENTHALTEND PROGESTERONANTAGONISTEN UND GESTAGENEN 失效组合产品，避孕含孕激素拮抗剂与孕激素
公开(公告)号：EP0735882B1
公开(公告)日：2002-05-08
申请号：EP95905102.0
申请日：1994-12-22
IPC分类号： A61K31/57 , A61K31/565
CPC分类号： A61K31/565 , A61K31/57 , Y10S514/843 , A61K2300/00
摘要： The invention pertains to a combination product consisting of individual dosage units of a competitive progesterone antagonist and, sequentially thereto, individual dosage units of a compound with progestational activity, and to the use of this combination product in preparing contraceptives based on inhibition of implantation (receptivity inhibition).
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6.发明授权STEROIDESTER, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE PHARMAZEUTISCHE VERWENDUNG 失效甾族酯，PROCESS FOR THEIR和制药用
公开(公告)号：EP0942920B1
公开(公告)日：2002-01-30
申请号：EP97954725.4
申请日：1997-12-08
发明人： KLAR, Ulrich , CLEVE, Arwed , SCHWEDE, Wolfgang , NEEF, Günter , OTTOW, Eckhard , CHWALISZ, Kristof , SCHNEIDER, Martin
IPC分类号： C07J53/00 , A61K31/565
CPC分类号： C07J53/002 , Y10S514/843
摘要： Disclosed are novel steroid esters of formula (I), wherein m means 1 or 2, n is 0 or 1, X is F or CN and the line drawn between carbon atoms 15 and 16 symbolizes the possible presence of a dual bond, excluding compound (Z)-6'-(4-cyanphenyl)-9,11 alpha -dihydro-17 beta -hydroxy-17 alpha -[3-(1-oxo-2-methylpropoxy)-1-propenyl]-4'H-naphto[3',2',1';10,9,11] ester-4-en-3-on. Derivatization occurs with a carboxylic acid. The novel compounds are characterized by a significantly enhanced solubility in comparison with the basic hydroxy compounds, and by enhanced biological effectiveness and selectivity. Said novel compounds are suitable for the production of medicaments.
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7.发明公开KOMPETITIVE PROGESTERONANTAGONISTEN ZUR BEDARFSORIENTIERTEN WEIBLICHEN FERTILITÄTSKONTROLLE 失效竞争孕激素拮抗剂需求为导向女性生育控制
公开(公告)号：EP0787002A1
公开(公告)日：1997-08-06
申请号：EP95937845.0
申请日：1995-10-24
CPC分类号： A61K31/567 , A61K31/00 , A61K31/569 , A61K31/575 , A61K31/58 , Y10S514/843
摘要： The present invention concerns the novel use of competitive progesterone antagonists in the preparation of a drug for regulating female fertility as required (pill to be taken as required). This drug can be administered in a single dose at any time during the menstrual cycle, its dosage being less than the ovulation-inhibiting dosage.
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8.发明公开TREATMENT OF CLIMACTERIC DISORDERS WITH NITRIC OXIDE SYNTHASE SUBSTRATES AND/OR DONORS 失效用硝酸衬底和/或DONORS更年期症状治疗
公开(公告)号：EP0730445A1
公开(公告)日：1996-09-11
申请号：EP95900760.0
申请日：1994-11-17
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/341 , A61K31/57 , A61K31/60 , Y10S514/899 , A61K31/41 , A61K31/34 , A61K31/21 , A61K2300/00 , A61K31/557 , A61K31/26
摘要： The symptoms of the climacterium are ameliorated by the administration to an afflicted individual one or both of a nitric oxide substrate and/or nitric acid donor, alone or optionally in combination with a progestin or, in the case of non-pregnant female, either a progestin or an estrogen or both.
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9.发明授权USE OF NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR, OR A NITRIC OXIDE INHIBITOR FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF UTERINE CONTRACTILITY DISORDERS 失效一氧化氮合酶基材和/或或捐助STICKSTOFFOXIDHEMMER的药品生产用于病症子宫活动的处理
公开(公告)号：EP0730448B1
公开(公告)日：2002-02-06
申请号：EP95900759.2
申请日：1994-11-17
IPC分类号： A61K31/195 , A61K31/04
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/557 , A61K31/57 , A61K38/11 , A61K31/41 , A61K31/34 , A61K31/295 , A61K31/21 , A61K2300/00
摘要： Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in combination with one or more of a prostaglandin inhibitor, a prostacyclin-mimetic, a progestin, an oxytocin antagonist or a β-agonist in an amount effective to ameliorate the symptoms thereof; and inadequate menses treated and induction of abortion or stimulation of labor in a pregnant female is achieved by uterine contractility stimulation by administering thereto a nitric oxide inhibitor, either alone or in a combination of progesterone antagonist, an oxytocin or oxytocin analogue antagonist or prostaglandin.
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10.发明授权KOMBINATION VON PROGESTERONANTAGONISTEN UND ANTIÖSTROGENEN MIT PARTIALER AGONISTISCHER WIRKUNG FÜR DIE HORMONSUBSTITUTIONS-THERAPIE FÜR PERI- UND POSTMENOPAUSALE FRAUEN 失效组合孕激素拮抗剂与激素治疗部分激动效应代课，围绝经期和绝经后妇女雌激素拮抗剂
公开(公告)号：EP0723439B1
公开(公告)日：2000-09-13
申请号：EP94929553.9
申请日：1994-10-17
IPC分类号： A61K31/00 , A61K31/565 , A61K31/135 , A61K31/40 , A61K31/38
CPC分类号： A61K31/565 , A61K31/575 , Y10S514/01 , A61K31/40 , A61K31/135 , A61K31/445 , A61K2300/00
摘要： The application describes the use of at least one compound with progesterone antagonistic (PA) action and at least one compound with anti-oestrogenic (AO) action, together with partial agonistic action, in the preparation of drugs for hormone-replacement therapy (HRT) for peri- and post-menopausal women. When PA and AO are used in combination, the stimulation of the endometrium which is caused by the partial agonistic action of the AO when the AO is used alone is inhibited by the PA. A drug as proposed by the invention could, for instance, contain onapriston (PA) and tamoxifen (AO).
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