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1.发明公开USE OF NITRIC OXIDE DONORS OR NITRIC OXIDE INHIBITORS FOR REGULATING CERVICAL DILATATION AND EXTENSIBILITY 无效USE STICKSTOFFOXYDDONOREN或拮抗剂的调颈椎应变
公开(公告)号：EP0814785A1
公开(公告)日：1998-01-07
申请号：EP96909707.0
申请日：1996-03-14
CPC分类号： A61K45/06 , A61K31/04 , A61K31/198 , A61K31/21 , A61K31/223 , A61K31/295 , A61K31/34
摘要： The invention describes the regulation of cervical dilatation and extensibility by the use of nitric oxide donors and/or substrates or nitric oxide inhibitors. There can be used either (a) at least one nitric oxide donor and/or substrate for manufacture of a medicament to be administered locally intracervically or intravaginally for induction of cervical ripening or (b) at least one nitric oxide inhibitor for manufacture of a medicament to be administered locally intracervically or intravaginally for treatment of cervical insufficiency or preterm labor.
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2.发明公开TREATMENT OF URINARY INCONTINENCE WITH NITRIC OXIDE SYNTHASE SUBSTRATES AND/OR NITRIC OXIDE DONORS 失效尿失禁用氮气氧化氮合酶衬底及/或治疗DONORS
公开(公告)号：EP0874627A1
公开(公告)日：1998-11-04
申请号：EP97902990.0
申请日：1997-01-21
CPC分类号： A61K31/566 , A61K31/198 , A61K31/21 , A61K31/295 , A61K31/34 , A61K31/56 , A61K31/565 , A61K31/569 , A61K31/57 , A61K31/575 , A61K2300/00
摘要： The invention provides a method for the treatment and prevention of urinary incontinence in mammals, e.g., human males and females, especially nonpregnant female mammals, by administering a nitric oxide synthase substrate and/or nitric oxide donor, alone or in combination with an estrogenic agent and/or a progestational substance, with or without supplementation with an alpha-adrenergic agonist, beta-adrenergic receptor blocking agent, cholinergic-receptor blocking compound or a cholinergic-receptor-stimulating drug, as well as pharmaceutical compositions useful in practicing the methods of this invention.
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3.发明授权USE OF NITRIC OXIDE DONORS OR NITRIC OXIDE INHIBITORS FOR REGULATING CERVICAL DILATATION AND EXTENSIBILITY 无效USE STICKSTOFFOXYDDONOREN或拮抗剂的调颈椎应变
公开(公告)号：EP0814785B1
公开(公告)日：2007-11-07
申请号：EP96909707.0
申请日：1996-03-14
IPC分类号： A61K31/04 , A61K31/195 , A61P15/04
CPC分类号： A61K45/06 , A61K31/04 , A61K31/198 , A61K31/21 , A61K31/223 , A61K31/295 , A61K31/34
摘要： The invention describes the regulation of cervical dilatation and extensibility by the use of nitric oxide donors and/or substrates or nitric oxide inhibitors. There can be used either (a) at least one nitric oxide donor and/or substrate for manufacture of a medicament to be administered locally intracervically or intravaginally for induction of cervical ripening or (b) at least one nitric oxide inhibitor for manufacture of a medicament to be administered locally intracervically or intravaginally for treatment of cervical insufficiency or preterm labor.
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4.发明公开PROGESTERONANTAGONISTISCH- UND ANTIÖSTROGEN WIRKSAME VERBINDUNGEN ZUR GEMEINSAMEN VERWENDUNG FÜR DIE WEIBLICHE KONTRAZEPTION 失效PROGESTERONANTAGONISTISCH-和抗雌激素活性的化合物为女性避孕的使用
公开(公告)号：EP0799042A1
公开(公告)日：1997-10-08
申请号：EP95943194.0
申请日：1995-12-23
CPC分类号： A61K31/567 , A61K31/138 , A61K2300/00
摘要： The invention concerns the use of at least one compound with progesterone-antagonistic properties and at least one compound with anti-oestrogen properties, each in a dose which would not in itself inhibit ovulation, in a single dosing unit, in order to prepare medicaments for female contraception.
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5.发明公开TREATMENT OF UTERINE CONTRACTILITY DISORDERS WITH A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR, OR A NITRIC OXIDE INHIBITOR 失效处理与及其一氧化氮合酶底物和/或捐助，或STICKSTOFFOXIDHEMMER子宫收缩的申诉
公开(公告)号：EP0730448A1
公开(公告)日：1996-09-11
申请号：EP95900759.0
申请日：1994-11-17
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/557 , A61K31/57 , A61K38/11 , A61K31/41 , A61K31/34 , A61K31/295 , A61K31/21 , A61K2300/00
摘要： Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in combination with one or more of a prostaglandin inhibitor, a prostacyclin-mimetic, a progestin, an oxytocin antagonist or a β-agonist in an amount effective to ameliorate the symptoms thereof; and inadequate menses treated and induction of abortion or stimulation of labor in a pregnant female is achieved by uterine contractility stimulation by administering thereto a nitric oxide inhibitor, either alone or in a combination of progesterone antagonist, an oxytocin or oxytocin analogue antagonist or prostaglandin.
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6.发明公开COMBINATION OF A PROGESTATIONAL AGENT AND A NITRIC OXIDE SYNTHASE SUBSTRATE AND/OR DONOR FOR THE TREATMENT OF PREECLAMPSIA AND PRETERM LABOR 失效组合物先兆子痫和早期出生到PROGESTATIVES剂处理和氮氧化物合酶衬底和/或供体CONTAINS
公开(公告)号：EP0708647A1
公开(公告)日：1996-05-01
申请号：EP94924261.0
申请日：1994-07-18
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/341 , A61K31/57 , A61K31/60 , Y10S514/841 , Y10S514/843 , Y10S514/866 , Y10S514/903 , A61K31/557 , A61K31/34 , A61K31/26 , A61K31/21 , A61K2300/00
摘要： Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase inhibitor, a PGI2-mimetic, a thromboxane (TXA2) inhibitor, a compound possessing TXA2-agonistic and TXA2-inhibiting properties, a compound possessing TXA2-antagonistic and PGI2-memetic activities, and a TXA2 antagonist.
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7.发明授权KOMBINATIONSPRODUKT ZUR KONTRAZEPTION ENTHALTEND PROGESTERONANTAGONISTEN UND GESTAGENEN 失效组合产品，避孕含孕激素拮抗剂与孕激素
公开(公告)号：EP0735882B1
公开(公告)日：2002-05-08
申请号：EP95905102.0
申请日：1994-12-22
IPC分类号： A61K31/57 , A61K31/565
CPC分类号： A61K31/565 , A61K31/57 , Y10S514/843 , A61K2300/00
摘要： The invention pertains to a combination product consisting of individual dosage units of a competitive progesterone antagonist and, sequentially thereto, individual dosage units of a compound with progestational activity, and to the use of this combination product in preparing contraceptives based on inhibition of implantation (receptivity inhibition).
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8.发明授权STEROIDESTER, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE PHARMAZEUTISCHE VERWENDUNG 失效甾族酯，PROCESS FOR THEIR和制药用
公开(公告)号：EP0942920B1
公开(公告)日：2002-01-30
申请号：EP97954725.4
申请日：1997-12-08
发明人： KLAR, Ulrich , CLEVE, Arwed , SCHWEDE, Wolfgang , NEEF, Günter , OTTOW, Eckhard , CHWALISZ, Kristof , SCHNEIDER, Martin
IPC分类号： C07J53/00 , A61K31/565
CPC分类号： C07J53/002 , Y10S514/843
摘要： Disclosed are novel steroid esters of formula (I), wherein m means 1 or 2, n is 0 or 1, X is F or CN and the line drawn between carbon atoms 15 and 16 symbolizes the possible presence of a dual bond, excluding compound (Z)-6'-(4-cyanphenyl)-9,11 alpha -dihydro-17 beta -hydroxy-17 alpha -[3-(1-oxo-2-methylpropoxy)-1-propenyl]-4'H-naphto[3',2',1';10,9,11] ester-4-en-3-on. Derivatization occurs with a carboxylic acid. The novel compounds are characterized by a significantly enhanced solubility in comparison with the basic hydroxy compounds, and by enhanced biological effectiveness and selectivity. Said novel compounds are suitable for the production of medicaments.
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9.发明公开KOMPETITIVE PROGESTERONANTAGONISTEN ZUR BEDARFSORIENTIERTEN WEIBLICHEN FERTILITÄTSKONTROLLE 失效竞争孕激素拮抗剂需求为导向女性生育控制
公开(公告)号：EP0787002A1
公开(公告)日：1997-08-06
申请号：EP95937845.0
申请日：1995-10-24
CPC分类号： A61K31/567 , A61K31/00 , A61K31/569 , A61K31/575 , A61K31/58 , Y10S514/843
摘要： The present invention concerns the novel use of competitive progesterone antagonists in the preparation of a drug for regulating female fertility as required (pill to be taken as required). This drug can be administered in a single dose at any time during the menstrual cycle, its dosage being less than the ovulation-inhibiting dosage.
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10.发明公开TREATMENT OF CLIMACTERIC DISORDERS WITH NITRIC OXIDE SYNTHASE SUBSTRATES AND/OR DONORS 失效用硝酸衬底和/或DONORS更年期症状治疗
公开(公告)号：EP0730445A1
公开(公告)日：1996-09-11
申请号：EP95900760.0
申请日：1994-11-17
CPC分类号： A61K31/565 , A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/341 , A61K31/57 , A61K31/60 , Y10S514/899 , A61K31/41 , A61K31/34 , A61K31/21 , A61K2300/00 , A61K31/557 , A61K31/26
摘要： The symptoms of the climacterium are ameliorated by the administration to an afflicted individual one or both of a nitric oxide substrate and/or nitric acid donor, alone or optionally in combination with a progestin or, in the case of non-pregnant female, either a progestin or an estrogen or both.
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