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1.发明授权TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环酰胺和尿素衍生物用于抑制G蛋白功能和治疗疾病的PROLIFERATINEN
公开(公告)号：EP0723540B1
公开(公告)日：2001-12-12
申请号：EP94930650.0
申请日：1994-10-12
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , REMISZEWSKI, Stacy, W. , TAVERAS, Arthur, G. , WOLIN, Ronald, L.
IPC分类号： C07D401/04 , C07D221/16 , C07D401/14 , A61K31/55 , C07D401/12
CPC分类号： C07D231/12 , A61K31/444 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
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2.发明公开TRICYCLIC SULFONAMIDE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环磺酰胺衍生物用于抑制G-蛋白功能及治疗增生ERKRANTUNGEN的BEKANDLUNG
公开(公告)号：EP0723539A1
公开(公告)日：1996-07-31
申请号：EP94930649.0
申请日：1994-10-12
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J.
CPC分类号： C07D401/04 , C07D221/16 , C07D409/14 , C07D417/14
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound containing a tricyclic ring system to a biological system. In particular, the method inhibits cellular growth in a mammal such as a human being. Novel compounds of formula (4.0) are disclosed. Also disclosed are processes for making 3-substituted compounds of formula (4.0). Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of formula (4.0).
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3.发明公开TRICYCLIC CARBAMATE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环氨基甲酸酯衍生物用于抑制G-蛋白质功能和用于治疗增生性疾病
公开(公告)号：EP0723538A1
公开(公告)日：1996-07-31
申请号：EP94930074.0
申请日：1994-10-12
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , REMISZEWSKI, Stacy, W. , TAVERAS, Arthur, G. , WOLIN, Ronald, L.
CPC分类号： C07D401/04 , A61K31/4545 , A61K31/496 , C07D221/16 , C07D401/12 , C07D401/14 , Y02A50/395
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of formula (1.0). Also disclosed are novel compounds of formulae (1.1, 1.2 and 1.3). Also disclosed are processes for making 3-substituted compounds of formulae (1.1, 1.2 and 1.3). Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of formulae (1.1, 1.2 and 1.3).
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4.发明公开TRICYCLIC CARBAMATE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环氨基甲酸酯衍生物用于抑制G-蛋白质功能和用于治疗增生性疾病
公开(公告)号：EP0817632A1
公开(公告)日：1998-01-14
申请号：EP96908751.0
申请日：1996-03-21
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , WOLIN, Ronald, L. , TAVERAS, Arthur, G. , REMISZEWSKI, Stacy, W.
CPC分类号： C07D401/12 , A61K31/4545 , A61K31/496 , C07D221/16 , C07D401/04 , C07D401/14
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound selected from (800.00), (801.00), (802.00), (803.00), (804.00), or (805.00). Compounds of structures (800.00) - (805.00) are novel compounds.
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5.发明公开TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环酰胺和脲衍生物如适用G-蛋白质功能和抑制剂治疗增殖疾病治疗
公开(公告)号：EP0815100A1
公开(公告)日：1998-01-07
申请号：EP96909651.0
申请日：1996-03-21
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , WOLIN, Ronald, L. , TAVERAS, Arthur, G. , REMISZEWSKI, Stacy, W.
CPC分类号： C07D231/12 , A61K31/444 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds wherein X is N, C or OH and R is (I) or (II) are disclosed.
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6.发明授权TRICYCLIC CARBAMATE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环氨基甲酸酯衍生物用于抑制G-蛋白质功能和用于治疗增生性疾病
公开(公告)号：EP0723538B1
公开(公告)日：2001-12-12
申请号：EP94930074.3
申请日：1994-10-12
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , REMISZEWSKI, Stacy, W. , TAVERAS, Arthur, G. , WOLIN, Ronald, L.
IPC分类号： C07D401/04 , A61K31/445 , C07D221/16 , C07D401/14 , C07D401/12
CPC分类号： C07D401/04 , A61K31/4545 , A61K31/496 , C07D221/16 , C07D401/12 , C07D401/14 , Y02A50/395
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound of formula (1.0). Also disclosed are novel compounds of formulae (1.1, 1.2 and 1.3). Also disclosed are processes for making 3-substituted compounds of formulae (1.1, 1.2 and 1.3). Further disclosed are novel compounds which are intermediates in the processes for making the 3-substituted compounds of formulae (1.1, 1.2 and 1.3).
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7.发明公开TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环酰胺和尿素衍生物用于抑制G蛋白功能和治疗疾病的PROLIFERATINEN
公开(公告)号：EP0723540A1
公开(公告)日：1996-07-31
申请号：EP94930650.0
申请日：1994-10-12
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , REMISZEWSKI, Stacy, W. , TAVERAS, Arthur, G. , WOLIN, Ronald, L.
CPC分类号： C07D231/12 , A61K31/444 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds of formulae (5.0, 5.1, 5.2, 5.3, 5.3A and 5.3B) are disclosed. Also disclosed are processes for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3). Further disclosed are novel compounds which are intermediates in the process for making 3-substituted compounds of formulae (5.0, 5.1, 5.2 and 5.3).
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8.发明授权TRICYCLIC AMIDE AND UREA COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环酰胺和脲衍生物如适用G-蛋白质功能和抑制剂治疗增殖疾病治疗
公开(公告)号：EP0815100B1
公开(公告)日：2006-06-21
申请号：EP96909651.0
申请日：1996-03-21
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , WOLIN, Ronald, L. , TAVERAS, Arthur, G. , REMISZEWSKI, Stacy, W.
IPC分类号： C07D401/04 , A61K31/445 , C07D401/14 , C07D401/12
CPC分类号： C07D231/12 , A61K31/444 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14
摘要： A method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells is disclosed. The method comprises the administration of a compound of formula (1.0) to a biological system. In particular, the method inhibits the abnormal growth of cells in a mammal such as a human being. Novel compounds wherein X is N, C or OH and R is (I) or (II) are disclosed.
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9.发明授权TRICYCLIC CARBAMATE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环氨基甲酸酯衍生物用于抑制G-蛋白质功能和用于治疗增生性疾病
公开(公告)号：EP0817632B1
公开(公告)日：2003-02-05
申请号：EP96908751.9
申请日：1996-03-21
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J. , WOLIN, Ronald, L. , TAVERAS, Arthur, G. , REMISZEWSKI, Stacy, W.
IPC分类号： A61K31/495 , A61P35/00
CPC分类号： C07D401/12 , A61K31/4545 , A61K31/496 , C07D221/16 , C07D401/04 , C07D401/14
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a compound selected from (800.00), (801.00), (802.00), (803.00), (804.00), or (805.00). Compounds of structures (800.00) - (805.00) are novel compounds.
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10.发明授权TRICYCLIC SULFONAMIDE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效三环磺酰胺衍生物用于抑制G-蛋白功能及治疗增生ERKRANTUNGEN的BEKANDLUNG
公开(公告)号：EP0723539B1
公开(公告)日：2001-12-12
申请号：EP94930649.2
申请日：1994-10-12
申请人： SCHERING CORPORATION
发明人： BISHOP, W., Robert , DOLL, Ronald, J. , MALLAMS, Alan, K. , NJOROGE, F., George , PETRIN, Joanne, M. , PIWINSKI, John, J.
IPC分类号： C07D401/04 , A61K31/445 , C07D221/16 , C07D401/14
CPC分类号： C07D401/04 , C07D221/16 , C07D409/14 , C07D417/14
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