公开(公告)号：EP1176871A4

公开(公告)日：2004-03-17

申请号：EP00932358

申请日：2000-05-11

申请人： SCIOS INC ,  LILLY CO ELI

发明人： ZHONG ZIYANG ,  CORDELL BARBARA ,  QUON DIANA HOM ,  LIU YU-WANG ,  XU QIANG ,  JOHNSTONE EDWARD MARION ,  HYSLOP PAUL ANDREW ,  SCHIMMOELLER FRAUKE ,  LITTLE SHEILA PARKS ,  QUEENER STEPHEN WYATT ,  YIN TINGGUI

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K45/00 ,  A61P25/28 ,  A61P43/00 ,  C07B61/00 ,  C12N9/64 ,  C12N9/99 ,  C12Q1/02 ,  C12Q1/37 ,  C12R1/91 ,  G01N33/15 ,  G01N33/53

CPC分类号： C12N9/6478 ,  A61K38/00 ,  C07K14/4711 ,  C12N9/6421 ,  C12Q1/37 ,  G01N33/6896 ,  G01N2500/00

摘要： The invention concerns a novel β-secretase, a method of partially purifying this novel β-secretase, and its use in assays to screen for potential drug candidates against Alzheimer's disease and other neurological diseases. The novel β-secretase has an estimated molecular weight of about 32-39 kDa or 22-26 kDa in HEK293 cell membrane extracts and human brain samples, respectively, as calculated from radiation inactivation analysis, and has a pH optimum at about pH 6.5-7.0.

公开(公告)号：EP0769051A4

公开(公告)日：1998-01-28

申请号：EP95926709

申请日：1995-07-14

申请人： LILLY CO ELI

发明人： QUEENER STEPHEN WYATT ,  ZOCK JOSEPH MARTIN

IPC分类号： C12N15/09 ,  C12N1/21 ,  C12N9/78 ,  C12N9/80 ,  C12N15/55 ,  C12P7/44 ,  C12P17/10 ,  C12P17/16 ,  C12P17/18 ,  C12P21/02

CPC分类号： C12P7/44 ,  C12N9/80 ,  C12P17/10 ,  C12P17/16 ,  C12P17/182 ,  Y10S930/30