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公开(公告)号：EP3031911B1
公开(公告)日：2018-12-05
申请号：EP15187136.5
申请日：2012-07-12
发明人： MARLIERE, Philippe
CPC分类号： C12P7/28 , C12N9/16 , C12N9/88 , C12N15/63 , C12P5/026 , C12P17/182 , C12P19/32 , C12Y301/03011 , C12Y401/02009 , C12Y401/02022 , Y02P20/52
摘要： Described are recombinant microorganisms characterized by having phosphoketolase activity, having a diminished or inactivated Embden-Meyerhof-Parnas pathway (EMPP) by inactivation of the gene(s) encoding phosphofructokinase or by reducing phosphofructokinase activity as compared to a non-modified microorganism and having a diminished or inactivated oxidative branch of the pentose phosphate pathway (PPP) by inactivation of the gene(s) encoding glucose-6-phosphate dehydrogenase or by reducing glucose-6-phosphate dehydrogenase activity as compared to a non-modified microorganism. These microorganisms can be used for the production of useful metabolites such as acetone, isobutene or propene.
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公开(公告)号：EP2331115B3
公开(公告)日：2018-12-05
申请号：EP09807420.6
申请日：2009-08-17
IPC分类号： A61K38/45 , A61K31/7076 , C12N9/10 , A61P35/00
CPC分类号： A61K38/45 , A61K31/7076 , A61K35/12 , A61K48/00 , A61K48/005 , C12N9/1077 , C12N2799/022 , C12N2799/027 , C12N2799/04 , C12P17/182 , C12Y204/02001 , Y02A50/473 , A61K2300/00
摘要： A process for inhibiting a mammalian cancerous cell or virally infected cell includes providing a Trichomonas vaginalis purine nucleoside phosphorylase enzyme or a tail mutant purine nucleoside phosphorylase enzyme in proximity to the mammalian cancerous cell or the virally infected cell and exposing the enzyme to a purine nucleoside phosphorylase enzyme cleavable substrate to yield a cytotoxic purine analog. The process includes introducing to the cell a vector containing the phosphorylase enzyme, or a DNA sequence coding for the same and delivering to the cell an effective amount of the substrate such as 9-(²-D-arabinofuranosyl)-2-fluoroadenine (F-araA).
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公开(公告)号：EP2978836B1
公开(公告)日：2018-09-26
申请号：EP14713106.4
申请日：2014-03-27
申请人： Roquette Frères
发明人： MACQUART, Gabriel
CPC分类号： C12P23/00 , C12N1/12 , C12P7/6409 , C12P7/6427 , C12P17/165 , C12P17/182 , C12P19/42
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公开(公告)号：EP2961844B1
公开(公告)日：2018-09-26
申请号：EP14757245.7
申请日：2014-02-24
申请人： Codexis, Inc.
CPC分类号： C12N9/1096 , C07D487/04 , C12P13/001 , C12P17/182 , C12Y206/01
摘要： The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.
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公开(公告)号：EP3353313A2
公开(公告)日：2018-08-01
申请号：EP16778886.8
申请日：2016-09-22
申请人： Pfizer Inc.
发明人： HILLER, Gregory Walter , MITCHELL, Jeffrey Joseph , MULUKUTLA, Bhanu Chandra , PEGMAN, Pamela Mary
IPC分类号： C12P21/00 , C07K16/00 , C07K14/435
CPC分类号： C12P7/62 , C07K16/00 , C12N2500/32 , C12N2500/34 , C12N2510/00 , C12N2510/02 , C12N2511/00 , C12P7/40 , C12P7/42 , C12P7/52 , C12P7/56 , C12P17/182
摘要： The invention relates to a method of cell culture where the cells are modified to reduce the level of synthesis of growth and/or productivity inhibitors by the cell. The invention also relates to a method of cell culture for improving cell growth and productivity, in particular in fed-batch culture of mammalian cells at high cell density. The invention further relates to a method of producing cells with improved cell growth and/or productivity in cell culture and to cells obtained or obtainable by such methods.
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6.发明公开ANTI-DANDRUFF COMPOSITIONS COMPRISING A SPIROFURANONE LACTAM TETRAMIC ACID DERIVATIVE 审中-公开含有螺内酯半乳糖苷四元酸衍生物的抗DONDRUFF组合物
公开(公告)号：EP3302713A1
公开(公告)日：2018-04-11
申请号：EP16730463.3
申请日：2016-06-08
IPC分类号： A61Q5/00 , A61K31/00 , A61K31/336
CPC分类号： A61K31/407 , A61K8/4973 , A61K31/336 , A61K31/4025 , A61Q5/006 , C12P17/162 , C12P17/182 , C12R1/645 , A61K2300/00
摘要： Anti-Dandruff Agents A novel anti-dandruff composition comprising spirofuranone-lactam tetramic acid or derivatives thereof, and optionally at least one biologically derivable meroterpene. The spirofuranone-lactam tetramic acid is preferably a bio-active heterospirocyclic secondary metabolite of Aspergillus, such as pseurotin A. The biologically derivable meroterpene may be selected from fumagillin, fumagillin derivative, chlovalicin, or ovalicin. Use of said agents as anti-dandruff actives in anti-dandruff compositions, particularly shampoos and conditioners is also provided. The active is particularly effective against Malassezia yeasts and Malassezia furfur which may cause dandruff. A method of obtaining the anti-dandruff actives from culturing of Peyronellaea sp. strain RKDO347 is also described.
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公开(公告)号：EP3223621A1
公开(公告)日：2017-10-04
申请号：EP15862653.1
申请日：2015-11-24
IPC分类号： A23F5/00
CPC分类号： C12P17/182 , C07D473/12 , C12N9/1007 , C12N9/78 , C12Y305/04003
摘要： The present invention provides an enzymatic means for the biosynthetic production of caffeine. The present invention provides biosynthetic methods for production of caffeine comprising: providing guanine, a guanine deaminase, at least one methyl transferase, and a methyl donor; contacting the guanine with the gtheuanine deaminase to produce xanthine; contacting the xanthine with the methyl transferase and a methyl donor, under conditions wherein the xanthine is methylated, to produce a monomethylxanthine; contacting the monomethylxanthine with the methyl transferase and a methyl donor, under conditions wherein the monomethylxanthine is methylated, to produce a dimethylxanthine; and contacting the dimethylxanthine with the methyl transferase and a methyl donor, under conditions wherein the dimethylxanthine is methylated, to produce caffeine (i.e., 1,3,7-trimethylxanthine).
摘要翻译： 本发明提供了用于生物合成咖啡因生产的酶手段。 本发明提供了生产咖啡因的生物合成方法，包括：提供鸟嘌呤，鸟嘌呤脱氨酶，至少一种甲基转移酶和甲基供体; 使鸟嘌呤与鸟嘌呤脱氨酶接触以产生黄嘌呤; 在黄嘌呤被甲基化的条件下使黄嘌呤与甲基转移酶和甲基供体接触以产生单甲基黄嘌呤; 在单甲基黄嘌呤被甲基化的条件下，使单甲基黄嘌呤与甲基转移酶和甲基供体接触以产生二甲基黄嘌呤; 并在二甲基黄嘌呤被甲基化的条件下使二甲基黄嘌呤与甲基转移酶和甲基供体接触以产生咖啡因（即1,3,7-三甲基黄嘌呤）。
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8.发明公开CYTOKININ SYNTHASE ENZYMES, CONSTRUCTS, AND RELATED METHODS 审中-公开CYTOKININSYNTHASEENZYME，KONSTRUKTE UNDZUGEHÖRIGEVERFAHREN
公开(公告)号：EP3146055A2
公开(公告)日：2017-03-29
申请号：EP15796311.7
申请日：2015-05-21
申请人： Dow AgroSciences LLC
CPC分类号： C12N9/1085 , A01N43/90 , A01N63/00 , C07K5/1021 , C07K2319/21 , C12N9/88 , C12P17/182 , C12P19/32 , C12Y205/01
摘要： The present disclosure relates to a new class of cytokinin biosynthetic enzymes, cytokinin synthases, which have two domains: an isopentenyl transfer (IPT)-like domain and a cytokinin nucleotide phosphoribohydrolase (PRH)-like domain. The invention provides compositions and methods for the recombinant production of cytokinin synthase, host cells and transformants that include the cytokinin synthases, as well as compositions and formulations that include the disclosed cytokinin synthase.
摘要翻译： 本公开涉及一类新的细胞分裂素生物合成酶，细胞分裂素合成酶，其具有两个结构域：异戊烯基转移（IPT）样结构域和细胞分裂素核苷酸磷酸水解酶（PRH）样结构域。 本发明提供了重组产生细胞分裂素合酶，宿主细胞和包括细胞分裂素合成酶的转化体的组合物和方法，以及包括所公开的细胞分裂素合成酶的组合物和制剂。
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9.发明授权GLYCOSYLATED INDOLECARBAZOLES, METHOD FOR OBTAINING SAME AND USES THEREOF 有权谷氨酰胺吲哚酮，VERFAHREN ZU DEREN GEWINNUNG UND ANWENDUNGEN DAVON
公开(公告)号：EP2277885B1
公开(公告)日：2017-03-15
申请号：EP09731404.1
申请日：2009-04-06
发明人： PÉREZ SALAS, Aaroa , SÁNCHEZ REILLO, César , FERNÁNDEZ BRAÑA, Alfredo , MÉNDEZ FERNÁNDEZ, Carmen , SALAS FERNÁNDEZ, Jose Antonio , MORÍS VARAS, Francisco
CPC分类号： C07H19/23 , C07H1/00 , C07H9/06 , C12N15/52 , C12N15/76 , C12P17/182 , C12P17/188 , C12P19/28
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公开(公告)号：EP2961844A4
公开(公告)日：2016-10-19
申请号：EP14757245
申请日：2014-02-24
申请人： CODEXIS INC
CPC分类号： C12P17/182 , C07D487/04 , C12N9/1096 , C12P13/001 , C12Y206/01
摘要： The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.
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