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公开(公告)号：EP1095141B1
公开(公告)日：2006-04-19
申请号：EP99932242.3
申请日：1999-07-08
申请人： SCIOS INC.
发明人： POLLITT, N., Stephen , BUCKLEY, Douglas, I. , STATHIS, Peter, A. , HARTMAN, Taymar, E. , ZHONG, Ziyang
CPC分类号： C07K1/36 , C07K1/122 , C07K14/58 , C07K2319/00 , C07K2319/35 , C07K2319/75 , C12N9/1033 , C12N15/62 , C12P21/06 , C12Y203/01028
摘要： A method is described for producing a peptide having a pI above 8 or below 5 wherein the peptide is expressed as a fusion protein in which it is linked to a fusion partner through an acid cleavage site. The peptide is released from the fusion partner by acid cleavage in the absence of chaotrope. The fusion partner and its acid cleavage products, if any, have a net charge sufficiently different from that of the desired peptide to allow isolation of the peptide by ion-exchange chromatography.
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公开(公告)号：EP1082431A2
公开(公告)日：2001-03-14
申请号：EP99926138.1
申请日：1999-06-03
申请人： SCIOS INC.
发明人： WHITE, R., Tyler , DAMM, Deborah , LESIKAR, David, D. , McFADDEN, Kathleen , GARRICK, Brett, L. , LUCAS, Anne, Bergstrom , POLLITT, N., Stephen , LAM, Andrew, O.
CPC分类号： C07K14/8114 , A61K38/00 , C07K14/4711
摘要： Analogues of the Kunitz Protease Inhibitor (KPI) domain of amyloid precursor protein bind to an inhibit activity of serine proteases, including kallikrein, plasmin and coagulation factors such as factors VIIa, IXa, Xa, XIa, and XIIa. Pharmaceutical compositions containing the KPI analogs, along with methods for using such compositions, are useful for ameliorating and treating clinical conditions associated with increased serine protease activity, such as blood loss related to cardiopulmonary bypass surgery. Nucleic acid sequences encoding these analogs and systems for expression of the peptides of the invention are provided.
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公开(公告)号：EP1095141A2
公开(公告)日：2001-05-02
申请号：EP99932242.3
申请日：1999-07-08
申请人： SCIOS INC.
发明人： POLLITT, N., Stephen , BUCKLEY, Douglas, I. , STATHIS, Peter, A. , HARTMAN, Taymar, E. , ZHONG, Ziyang
CPC分类号： C07K1/36 , C07K1/122 , C07K14/58 , C07K2319/00 , C07K2319/35 , C07K2319/75 , C12N9/1033 , C12N15/62 , C12P21/06 , C12Y203/01028
摘要： A method is described for producing a peptide having a pI above 8 or below 5 wherein the peptide is expressed as a fusion protein in which it is linked to a fusion partner through an acid cleavage site. The peptide is released from the fusion partner by acid cleavage in the absence of chaotrope. The fusion partner and its acid cleavage products, if any, have a net charge sufficiently different from that of the desired peptide to allow isolation of the peptide by ion-exchange chromatography.
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公开(公告)号：EP1183352A1
公开(公告)日：2002-03-06
申请号：EP00932525.9
申请日：2000-05-18
申请人： SCIOS INC.
摘要： The invention is directed to a method of enhancing the biological activity of vascular endothelial growth factors (VEGF). The invention further concerns certain VEGF variants having enhanced biological activity, methods and means for preparing these variants, and pharmaceutical compositions comprising them. In a further aspect, the invention concerns methods of treatment using, and articles of manufacture containing such VEGF variants.
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公开(公告)号：EP1183357A2
公开(公告)日：2002-03-06
申请号：EP00932559.8
申请日：2000-05-18
申请人： SCIOS INC.
发明人： JUE, Rodney, Alan , SCHELLENBERGER, Ute , STATHIS, Peter, A. , ADRIAENSSENS, Peter, Isadore , ABRAHAM, Judith, A. , BALDWIN, Patricia, Ann , POLLITT, N., Stephen
CPC分类号： C07K14/52 , A61K38/00 , A61K2039/525 , C12N2740/15011
摘要： This invention concerns novel vascular endothelial growth factor (VEGF) dimers, compositions containing such dimers, processes for making such dimers, and methods for the treatment of various diseases by administering such dimers or compositions.
摘要翻译： 本发明涉及新的血管内皮生长因子（VEGF）二聚体，含有这种二聚体的组合物，制备这种二聚体的方法，以及通过施用这种二聚体或组合物治疗各种疾病的方法。
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