公开(公告)号：EP2068851A4

公开(公告)日：2010-07-14

申请号：EP07871111

申请日：2007-10-02

申请人： SCRIPPS RESEARCH INST

发明人： CRAVATT BENJAMIN F ,  CHIANG KYLE P ,  NIESSEN SHERRY ,  SAGHATELIAN ALAN

IPC分类号： A61K31/00 ,  C12Q1/34

CPC分类号： A61K31/325 ,  C12Q1/34 ,  G01N33/92 ,  G01N2500/02

公开(公告)号：EP1769071A4

公开(公告)日：2008-12-31

申请号：EP05788798

申请日：2005-06-01

申请人： SCRIPPS RESEARCH INST

发明人： CRAVATT BENJAMIN F ,  SAGHATELIAN ALAN ,  JESSANI NADIM ,  JOSEPH ARUL

IPC分类号： C12N9/50 ,  C07D249/04 ,  C12Q1/37 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6803 ,  C12Q1/37 ,  G01N33/573 ,  G01N33/6818 ,  G01N33/6842 ,  G01N2333/96486

摘要： Activity-based compositions for analyzing metalloproteases are disclosed, where the compositions include a chemical compound including a hydroxamate moiety and a benzophenone moiety. Methods for synthesizing these compounds are also disclosed, as well as methods of using them for determining the bioactivity of a compositions comprising active compounds toward a metalloproteases and for determining the potency of an inhibitor against a metalloprotease.