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    COMPOSITIONS AND METHODS FOR FLUID BIOPSY OF MELANOMA
    4.
    发明公开
    COMPOSITIONS AND METHODS FOR FLUID BIOPSY OF MELANOMA 审中-公开

    公开(公告)号：EP3140656A4

    公开(公告)日：2017-11-22

    申请号：EP15788742

    申请日：2015-05-08

    申请人： SCRIPPS RESEARCH INST

    发明人： KUHN PETER ,  VELASCO CARMEN RUIZ

    IPC分类号： G01N33/574 ,  G01N33/50 ,  G01N33/569

    CPC分类号： G01N33/5743 ,  G01N33/56972 ,  G01N33/57488 ,  G01N2333/70589

    摘要： The present invention provides methods for identifying circulating melanoma cells (CMCs) in a biological sample and methods for diagnosing metastatic melanoma in a subject. The methods disclosed can be used on non-enriched blood samples to identify CMC using detectable agents that are specific for a biomarker of CMCs and assessing the morphology of the cells having the detectable agents. The presence or absence of a detectable agent in combination with morphological characteristics of the cells can be used diagnose a subject with metastatic melanoma based on the number of CMCs is present in the sample.

    CIRCULATING TUMOR CELL DIAGNOSTICS FOR LUNG CANCER
    8.
    发明公开
    CIRCULATING TUMOR CELL DIAGNOSTICS FOR LUNG CANCER 审中-公开
    DIAGNOSE ZIRKULIERENDER TUMORZELLENFÜRLUNGENKREBS

    公开(公告)号：EP3090264A4

    公开(公告)日：2017-06-07

    申请号：EP14876751

    申请日：2014-12-23

    申请人： SCRIPPS RESEARCH INST ,  UNIV LELAND STANFORD JUNIOR

    发明人： KUHN PETER ,  CARLSSON ANDERS ,  KOLATKAR ANAND ,  GAMBHIR SANJIV SAM ,  NAIR VISWAM S

    IPC分类号： G01N33/574 ,  G01N21/00

    CPC分类号： G01N33/5026 ,  A61K49/00 ,  A61K51/0491 ,  G01N33/5005 ,  G01N2800/12 ,  G01N2800/7028

    摘要： The present invention provides methods for diagnosing lung cancer in a subject comprising (a) generating circulating tumor cell (CTC) data from a blood sample obtained from the subject based on a direct analysis comprising immunofluorescent staining and morphological characteristics of nucleated cells in the sample, wherein CTCs are identified in context of surrounding nucleated cells based on a combination of the immunofluorescent staining and morphological characteristics; (b) obtaining clinical data for the subject; (c) combining the CTC data with the clinical data to diagnose lung cancer in the subject.

    摘要翻译： 本发明提供了用于诊断受试者中肺癌的方法，其包括（a）基于包括免疫荧光染色和样品中有核细胞的形态特征的直接分析，从获自受试者的血液样品产生循环肿瘤细胞（CTC）数据， 其中基于免疫荧光染色和形态特征的组合在周围有核细胞的背景下鉴定CTC; （b）获得对象的临床数据; （c）将CTC数据与临床数据相结合以诊断受试者中的肺癌。

    GENOTYPIC AND PHENOTYPIC ANALYSIS OF CIRCULATING TUMOR CELLS TO MONITOR TUMOR EVOLUTION IN PROSTATE CANCER PATIENTS
    9.
    发明公开
    GENOTYPIC AND PHENOTYPIC ANALYSIS OF CIRCULATING TUMOR CELLS TO MONITOR TUMOR EVOLUTION IN PROSTATE CANCER PATIENTS 审中-公开
    GENOTYPEN- UNDPHÄNOTYPANANALYSEZIRKULIERENDER TUMORZELLEN ZURÜBERWACHUNGDER TUMORENTWICKLUNG BEI PATIENTEN MIT PROSTATAKREBS

    公开(公告)号：EP3052940A4

    公开(公告)日：2017-05-24

    申请号：EP14849862

    申请日：2014-09-30

    申请人： SCRIPPS RESEARCH INST ,  COLD SPRING HARBOR LABORATORIES ,  KUHN PETER ,  DAGO RODRIGUEZ ANGEL ERNESTO ,  CARLSSON ANDERS ,  LIU WEI ,  HICKS JIM

    发明人： KUHN PETER ,  DAGO RODRIGUEZ ANGEL ERNESTO ,  CARLSSON ANDERS ,  LIU WEI ,  HICKS JIM

    IPC分类号： G01N33/574

    CPC分类号： G01N33/57434 ,  G01N33/57488 ,  G01N33/57492 ,  G01N2800/52

    摘要： The present invention provides methods for predicting response to a hormone-directed therapy or chemotherapy in a prostate cancer (PCa) patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to identify and enumerate circulating tumor cells (CTC); (b) individually characterizing genotypic, morphometric and protein expression parameters to generate a profile for each of the CTCs, and (c) predicting response to hormone-directed therapy in the prostate cancer PCa patient based on said profile. In some embodiments, the methods comprise repeating steps (a) through (c) at one or more timepoints after initial diagnosis of prostate cancer to sequentially monitor said genotypic, morphometric and protein expression parameters.

    摘要翻译： 本发明提供了用于预测前列腺癌（PCa）患者对激素引导的疗法或化学疗法的反应的方法，其包括（a）进行直接分析，包括免疫荧光染色和从患者获得的血样中的有核细胞的形态表征， 鉴定和列举循环肿瘤细胞（CTC）; （b）分别表征基因型，形态计量学和蛋白质表达参数以产生每种CTC的谱，以及（c）基于所述谱预测前列腺癌PCa患者对激素引导疗法的反应。 在一些实施方案中，所述方法包括在初次诊断前列腺癌之后的一个或多个时间点重复步骤（a）至（c），以顺序监测所述基因型，形态计量和蛋白质表达参数。