公开(公告)号：EP3090264A4

公开(公告)日：2017-06-07

申请号：EP14876751

申请日：2014-12-23

申请人： SCRIPPS RESEARCH INST ,  UNIV LELAND STANFORD JUNIOR

发明人： KUHN PETER ,  CARLSSON ANDERS ,  KOLATKAR ANAND ,  GAMBHIR SANJIV SAM ,  NAIR VISWAM S

IPC分类号： G01N33/574 ,  G01N21/00

CPC分类号： G01N33/5026 ,  A61K49/00 ,  A61K51/0491 ,  G01N33/5005 ,  G01N2800/12 ,  G01N2800/7028

摘要： The present invention provides methods for diagnosing lung cancer in a subject comprising (a) generating circulating tumor cell (CTC) data from a blood sample obtained from the subject based on a direct analysis comprising immunofluorescent staining and morphological characteristics of nucleated cells in the sample, wherein CTCs are identified in context of surrounding nucleated cells based on a combination of the immunofluorescent staining and morphological characteristics; (b) obtaining clinical data for the subject; (c) combining the CTC data with the clinical data to diagnose lung cancer in the subject.

摘要翻译： 本发明提供了用于诊断受试者中肺癌的方法，其包括（a）基于包括免疫荧光染色和样品中有核细胞的形态特征的直接分析，从获自受试者的血液样品产生循环肿瘤细胞（CTC）数据， 其中基于免疫荧光染色和形态特征的组合在周围有核细胞的背景下鉴定CTC; （b）获得对象的临床数据; （c）将CTC数据与临床数据相结合以诊断受试者中的肺癌。

公开(公告)号：EP2491395A4

公开(公告)日：2013-05-22

申请号：EP10825626

申请日：2010-10-20

申请人： SCRIPPS RESEARCH INST ,  EPIC SCIENCES INC

发明人： KUHN PETER ,  KOLATKAR ANAND ,  KUNKEN JOSHUA ,  MARRINUCCI DENA ,  YANG XING ,  STUELPNAGEL JOHN R

IPC分类号： G01N33/574

CPC分类号： G01N33/574 ,  G01N33/5076 ,  G01N33/5091 ,  G01N33/6875 ,  G01N2800/52 ,  G01N2800/56

摘要： The invention provides seminal computational approaches utilizing data from non-rare cells to detect rare cells, such as circulating tumor cells (CTCs). The invention is applicable at two distinct stages of CTC detection; the first being to make decisions about data collection parameters and the second being to make decisions during data reduction and analysis. Additionally, the invention utilizes both one and multi-dimensional parameterized data in a decision making process.

公开(公告)号：EP3080245A4

公开(公告)日：2017-05-17

申请号：EP14869363

申请日：2014-12-08

申请人： SCRIPPS RESEARCH INST ,  KUHN PETER ,  LUTTGEN MADELYN ,  KOLATKAR ANAND

发明人： KUHN PETER ,  LUTTGEN MADELYN ,  KOLATKAR ANAND

IPC分类号： C12N5/071 ,  C12N5/07 ,  C12N5/10

CPC分类号： G01N33/6887 ,  G01N2333/70503 ,  G01N2333/70589 ,  G01N2333/745 ,  G01N2800/324

公开(公告)号：EP2788773A4

公开(公告)日：2015-09-09

申请号：EP12855719

申请日：2012-12-07

申请人： SCRIPPS RESEARCH INST ,  MARIENFELD GERD

发明人： MARIENFELD GERD ,  KUHN PETER ,  KOLATKAR ANAND ,  MARRINUCCI DENA

IPC分类号： G01N33/74 ,  G02B21/34

CPC分类号： G01N33/57492 ,  B01L3/508 ,  B01L3/5088 ,  B01L2300/0822 ,  B01L2300/161 ,  G01N33/4833 ,  G01N33/5011 ,  G02B21/34 ,  G02B21/365