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公开(公告)号：EP1034793A4
公开(公告)日：2003-07-09
申请号：EP99937073
申请日：1999-08-13
IPC分类号： C07D213/75 , A61K9/20 , A61K31/00 , A61K31/437 , A61K31/44 , A61K31/4409 , A61K31/4545 , A61K31/496 , A61K31/551 , A61K45/00 , A61P27/02 , A61P27/06 , A61P27/10 , A61P43/00 , C07D471/04 , A61K31/445
CPC分类号： A61K31/551 , A61K31/00 , A61K31/437 , A61K31/4409 , A61K31/4545 , A61K31/496 , Y10S514/912 , Y10S514/913
摘要： Preventives/remedies for glaucoma containing compounds having an Rho kinase inhibitory activity, in particular, those represented by general formula (I), wherein each symbol is as defined in the specification. These preventives/remedies are novel ones having effects of lowering ocular tension, ameliorating optic papilla blood flow and promoting humor aqueous outflow.
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公开(公告)号：EP1112749A4
公开(公告)日：2004-06-16
申请号：EP99937066
申请日：1999-08-12
申请人： SENJU PHARMA CO
发明人： INOUE JUN , WAKI MITSUNORI
IPC分类号： A61K9/00 , A61K31/00 , A61K31/4166 , A61K45/00 , A61K31/40 , A61K31/445 , A61K31/505 , A61K31/53 , A61K31/66
CPC分类号： A61K31/4166 , A61K9/0048 , A61K31/00
摘要： To treat diseases caused by eye circulatory failure including glaucoma, there have been used various drugs, for example, steroid preparations for oral administration and eye drops containing sympathetic β-blocking agents. However, these drugs each suffers from some problem such as an insufficient effect or the occurrence of a side effect associated with the drug function. Preventives or remedies for diseases caused by eye circulatory failure characterized by comprising a chymase inhibitor which enable adequate prevention and treatment of these diseases while causing little side effect.
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3.发明公开
公开(公告)号：EP1179345A4
公开(公告)日：2006-08-09
申请号：EP00901928
申请日：2000-01-27
申请人： SENJU PHARMA CO , KYOTO PHARMA IND
发明人： WAKI MITSUNORI
IPC分类号： A61K31/496 , A61P27/00 , A61P29/00 , C07D211/90
CPC分类号： A61K31/496
摘要： Anti-inflammatory agents and inhibitors against increase in ocular tension caused by irradiation with lasers, containing as the active ingredient 1,4-dihydropyridine derivatives represented by general formula (I) or acid addition salts thereof wherein X and X are each independently hydrogen, fluoromethyl, fluoromethoxy, halogeno, cyano, or nitro; R is lower alkyl; R is acyl, alkoxycarbonyl, acylalkyl, N-alkylated carbamoylalkyl, alkoxyalkyl, alkoxycarbonylalkyl, acyloxyalkyl, nitratoalkyl, cyanoalkyl, heterocycle-bearing alkyl, haloalkyl, alkenyl, or alkynyl; A is alkylene bearing a carbon atom which two alkyl groups are bonded to and having 5 or more carbon atoms in total; and m is an integer of 1 to 3.
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4.发明公开
公开(公告)号：EP1224945A4
公开(公告)日：2004-08-18
申请号：EP00969999
申请日：2000-10-23
申请人： SENJU PHARMA CO
发明人： TSUZUKI MASAKATSU , WAKI MITSUNORI , KAWAMOTO YOKO
IPC分类号： A61K31/00 , A61K31/4166 , A61K31/4174 , A61K31/4188 , A61K31/513 , A61K38/00 , A61P27/10 , A61P43/00 , A61K45/00
CPC分类号： A61K38/005 , A61K31/00 , A61K31/4166 , A61K31/4174 , A61K31/4188 , A61K31/513
摘要： Use of a chymase inhibitor in preventing and treating nearsightedness caused by the continuous tension of ciliary muscles makes it possible to achieve exact preventive and therapeutic effects with little side effects.
摘要翻译： 使用糜蛋白酶抑制剂预防和治疗由睫状肌持续张力引起的近视，可以实现确切的预防和治疗效果，且副作用小。
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公开(公告)号：EP0955045A4
公开(公告)日：2000-11-15
申请号：EP97933066
申请日：1997-07-25
发明人： OGAWA TAKAHIRO , WATANABE NORIKO , WAKI MITSUNORI
CPC分类号： A61K31/18
摘要： Drugs for improving ocular circulation disorders which contain as the active ingredient 5-{1-hydroxy-2-[2-(2-methoxyphenoxy)ethylamino]ethyl}-2-methylbenzenesulfonamide or its acid-addition salt. These drugs are usable as preventives or remedies for various diseases caused by ocular circulation disorders, such as glaucoma with normal ocular tension, retinal pigment degeneration, macular degeneration, ischemic optic nerve disease, iridocyclitis, retinal arterial obliteration, retinal venous obliteration, diabetic retinopathy, choroid diseases following retinal lesions, and retinal choroid diseases associated with systemic diseases without showing any side effect. Also when dropped into the eyes, these drugs can exert excellent effects.
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公开(公告)号：EP0968716A4
公开(公告)日：2003-05-21
申请号：EP97909623
申请日：1997-10-23
申请人： SENJU PHARMA CO , KYOTO PHARMA IND
发明人： OGAWA TAKAHIRO , WATANABE NORIKO , WAKI MITSUNORI
IPC分类号： A61K31/4439 , A61K31/496 , A61K31/551 , A61K31/5377 , A61K45/06 , A61P27/00 , A61P27/06
CPC分类号： A61K31/4439 , A61K31/496 , A61K31/551 , Y10S514/912 , Y10S514/913
摘要： Drugs for ameliorating ocular circulatory disorders characterized by containing as the active ingredient 1,4-dihydropyridine derivatives represented by general formula (I) or acid-addition salts thereof, wherein each symbol is as defined in the specification. When dropped into the eyes, in particular, the above drugs enhance the blood flow in optic papillae and inhibit retinal vasoconstriction, a decrease in the blood flow in optic papillae and attenuation of VEP amplitude in the eyes with circulatory disorders caused by ET-1 without elevating the ocular tension. These facts suggest that the above drugs are useful as remedies for glaucoma, in particular with normal ocular tension, caused by ocular circulatory disorders, retinal pigment degeneration, macular degeneration, ischemic optic neuritis, iridocyclitis, retinal arterial obliteration, retinal phlebemphraxis, diabetic retinitis, choroid diseases following retinal lesions, retinal/choroid diseases associated to systemic diseases, etc.
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公开(公告)号：EP1050308A4
公开(公告)日：2002-09-04
申请号：EP99901151
申请日：1999-01-25
发明人： OGAWA TAKAHIRO , WATANABE NORIKO , WAKI MITSUNORI
摘要： Preventives or remedies for vision disorders based on ocular circulatory disorders (for example, intraocular hypertension and glaucoma) and vision disorders based on ciliary tension (for example, shortsightedness) which contain vasopressin antagonists as the active ingredient.
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