公开(公告)号：EP3290424A4

公开(公告)日：2018-03-07

申请号：EP16786500

申请日：2016-04-27

申请人： SHIONOGI & CO

发明人： KAWAI MAKOTO ,  TOMITA KENJI ,  AKIYAMA TOSHIYUKI ,  OKANO AZUSA ,  MIYAGAWA MASAYOSHI

IPC分类号： C07D498/14 ,  A61K31/53 ,  A61K31/5383 ,  A61K31/542 ,  A61P31/16 ,  C07D471/14 ,  C07D491/22 ,  C07D513/14

CPC分类号： A61K31/53 ,  A61K31/5383 ,  A61K31/542 ,  A61K31/553 ,  A61K31/675 ,  A61P31/16 ,  C07D471/14 ,  C07D471/20 ,  C07D491/22 ,  C07D498/14 ,  C07D513/14 ,  C07F9/6561

摘要： The present inventon provides the following compounds having anti-viral activity. A 1 is CR 1A R 1B , S or O; A 2 is CR 2A R 2B , S or O; A 3 is CR 3A R 3B , S or O; A 4 is CR 4A R 4B , S or O; the number of hetero atoms among atoms constituting the ring which consists of A 1 , A 2 , A 3 , A 4 , nitrogen atom adjacent to A 1 and carbon atom adjacent to A 1 , is 1 or 2; R 1A and R 1B are each independently hydrogen, halogen, alkyl, or the like; R 2A and R 2B are each independently hydrogen, halogen, alkyl, or the like; R 3A and R 3B are each independently hydrogen, halogen, alkyl, or the like; R 4A and R 4B are each independently hydrogen, halogen, alkyl, or the like; R 3A and R 3B may be taken together to form non-aromatic carbocycle or non-aromatic heterocycle; X is CH 2 , S or O; R 1 is each independently halogen, hydroxy, or the like; m is any integer of 0 to 2; and n is any integer of 1 to 2.

公开(公告)号：EP3192794A4

公开(公告)日：2018-06-27

申请号：EP15839901

申请日：2015-09-10

申请人： SHIONOGI & CO

发明人： KAWASUJI TAKASHI ,  MIKAMIYAMA HIDENORI ,  SUZUKI NAOYUKI ,  MASUDA KOJI ,  SUGIMOTO HIDEKI ,  OKANO AZUSA ,  YOSHIDA MIHO ,  SUGIYAMA SHUICHI ,  ASAHI KENTAROU ,  KOZONO IORI ,  MIYAZAKI KEISUKE ,  OZASA HIROKI ,  MIYAGAWA MASAYOSHI

IPC分类号： C07D231/56 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4436 ,  A61K31/4525 ,  A61P31/18 ,  A61P43/00 ,  C07D333/72 ,  C07D409/12 ,  C07D493/04 ,  C12N9/99

CPC分类号： C07D493/04 ,  A61K31/381 ,  A61K31/397 ,  A61K31/40 ,  A61K31/416 ,  A61K31/427 ,  A61K31/428 ,  A61K31/4436 ,  A61K31/4525 ,  A61P31/18 ,  C07D231/56 ,  C07D333/72 ,  C07D409/12 ,  C07D519/00 ,  C12N9/99

摘要： The present invention provides useful compounds for HIV protease inhibitor. A compound represented by formula or its pharmaceutically acceptable salt Formula: wherein ring A is R 4 is -Y-Z, hydrogen atom, halogen, hydroxy and the like, R 5 is hydrogen atom, halogen, hydroxy and the like, R 6 is each independently halogen, hydroxy, carboxy and the like, ring A may be substituted with said R 6 at any substitutable position(s), a is an integer of 0 to 7, ring B is substituted or unsubstituted aromatic carbocyclyl, or substituted or unsubstituted aromatic heterocyclyl, ring C is substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, R 1 is -Y-Z, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl and the like, R 2 and R 3 are each independently -Y-Z or hydrogen atom, provided that at least one of R 1 , R 2 , R 3 and R 4 is a group represented by formula: -Y-Z, Y is a bond, or a spacer of any combination selected from the group consisting of -O-, -S-, -NR 7 -, -C(=O)-, -SO-, -SO 2 -, -NR 7 -C(=O)-, -C(=O)-NR 7 -, -NR 7 -C(=O)-NR 7 -, -NR 7 -C(=O)-O-, -SO 2 -NR 7 -, -NR 7 -SO 2 -, substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, substituted or unsubstituted alkynylene, substituted or unsubstituted aromatic carbocyclediyl, substituted or unsubstituted non-aromatic carbocyclediyl, substituted or unsubstituted aromatic heterocyclediyl and substituted or unsubstituted non-aromatic heterocyclediyl, R 7 are each independently hydrogen atom, hydroxy, carboxy and the like, and Z is substituted aromatic carbocyclyl, substituted non-aromatic carbocyclyl, substituted aromatic heterocyclyl or substituted non-aromatic heterocyclyl.

公开(公告)号：EP2620436A4

公开(公告)日：2015-03-04

申请号：EP11826859

申请日：2011-09-21

申请人： SHIONOGI & CO

发明人： TAKAHASHI CHIKA ,  MIKAMIYAMA HIDENORI ,  AKIYAMA TOSHIYUKI ,  TOMITA KENJI ,  TAODA YOSHIYUKI ,  KAWAI MAKOTO ,  ANAN KOSUKE ,  MIYAGAWA MASAYOSHI ,  SUZUKI NAOYUKI

IPC分类号： C07D471/04 ,  A61K31/53 ,  A61P31/16 ,  A61P43/00 ,  C07D471/14

CPC分类号： C07D471/04 ,  C07D471/14 ,  C07F9/6561 ,  C07F9/65616

摘要： The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of the compound being a substituted 3 - hydroxy-4-pyridone derivative prodrug having cap-dependent endonuclease inhibitory activity.

摘要翻译： 本发明提供了具有抗病毒作用的化合物，特别是具有对流感病毒的生长抑制活性的化合物，该化合物是具有cap依赖性内切核酸酶抑制活性的取代的3-羟基-4-吡啶酮衍生物前药的优选实例。

公开(公告)号：EP2460794A4

公开(公告)日：2013-01-23

申请号：EP10804498

申请日：2010-07-29

申请人： SHIONOGI & CO

发明人： TACHIBANA YUUKI ,  MIYAGAWA MASAYOSHI ,  MASUDA TSUTOMU ,  HASEGAWA TSUYOSHI

IPC分类号： C07D207/34 ,  A61K31/404 ,  A61K31/496 ,  A61K31/4985 ,  A61P11/06 ,  A61P17/04 ,  A61P29/00 ,  A61P43/00 ,  C07D209/42 ,  C07D209/52 ,  C07D209/70 ,  C07D235/24 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052

CPC分类号： A61K31/404 ,  A61K9/0019 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/4866 ,  A61K31/496 ,  A61K31/4985 ,  C07C2601/02 ,  C07D207/34 ,  C07D209/42 ,  C07D209/52 ,  C07D235/24 ,  C07D401/06 ,  C07D403/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/052