公开(公告)号：EP0960935A4

公开(公告)日：2003-02-05

申请号：EP97954863

申请日：1997-02-07

申请人： SHIONOGI & CO ,  KISHIMOTO TADAMITSU

发明人： KISHIMOTO TADAMITSU ,  NAGASAWA TAKASHI ,  TACHIBANA KAZUNOBU ,  IIZASA HISASHI ,  YOSHIDA NOBUAKI ,  NAKAJIMA TOSHIHIRO ,  YOSHIE OSAMU

IPC分类号： A61K38/00 ,  C07K14/715 ,  C12N15/12 ,  A61K38/18 ,  A61K38/19 ,  C07K16/28 ,  C12N5/10 ,  C12P21/02 ,  C12P21/08 ,  G01N33/577

CPC分类号： C07K14/7158 ,  A61K38/00

摘要： A DNA encoding a polypeptide comprising the whole amino acid sequence described in SEQ. ID NO: 17 of the Sequence Listing or a part of the same or a polypeptide containing the above polypeptide which has a receptor activity capable of binding to mouse PBSF/SDF-1; a polypeptide encoded by this DNA and having a receptor activity capable of binding to mouse PBSF/SDF-1; cells expressing this polypeptide and human CD4 protein; and a method for screening an AIDS onset inhibitor, an HIV-1 infection inhibitor, etc. which comprises using the above-mentioned cells. Thus the invention provides a novel mouse CXC chemokine receptor gene which is useful in studies on a remedy for AIDS or the mode of action in the infection with HIV-1, a method for screening an HIV-1 infection inhibitor, etc.

公开(公告)号：EP0860446A4

公开(公告)日：2000-02-02

申请号：EP96932016

申请日：1996-09-27

申请人： SHIONOGI & CO

发明人： IMAI TOSHIO ,  YOSHIDA TETSUYA ,  YOSHIE OSAMU

IPC分类号： A61K38/00 ,  C07K14/52 ,  C12N15/19 ,  G01N33/68 ,  C07K16/24 ,  C12N5/10 ,  C12P21/02 ,  C12P21/08 ,  G01N33/53 ,  G01N33/577

CPC分类号： C07K14/523 ,  A61K38/00 ,  G01N33/6863 ,  G01N2500/00

摘要： An isolated novel type CC chemokine-like protein which is expressed from monocytes of peripheral blood under an immunological stimulus and has a cell migration activity; a DNA encoding the protein; an expression vector and a transformant containing the DNA; a process for producing a recombinant protein by using the transformant; and a medicinal composition containing the protein.