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公开(公告)号：EP2311495B1
公开(公告)日：2014-09-24
申请号：EP10181992.8
申请日：1999-03-23
IPC分类号： A61K45/00 , A61K39/395 , A61K48/00 , A61K31/70 , A61K31/56 , A61K38/43 , A61P35/00 , A61K35/00
CPC分类号： G01N33/5011 , A61K38/1793
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公开(公告)号：EP0960935B1
公开(公告)日：2009-08-05
申请号：EP97954863.3
申请日：1997-02-07
发明人： KISHIMOTO, Tadamitsu , NAGASAWA, Takashi , TACHIBANA, Kazunobu , IIZASA, Hisashi , YOSHIDA, Nobuaki , NAKAJIMA, Toshihiro , YOSHIE, Osamu
IPC分类号： C12N15/12 , C07K14/715 , C12N5/10 , C12P21/02 , C12P21/08 , C07K16/28 , A61K38/18 , A61K38/19 , G01N33/577
CPC分类号： C07K14/7158 , A61K38/00
摘要： A DNA encoding a polypeptide comprising the whole amino acid sequence described in SEQ. ID NO: 17 of the Sequence Listing or a part of the same or a polypeptide containing the above polypeptide which has a receptor activity capable of binding to mouse PBSF/SDF-1; a polypeptide encoded by this DNA and having a receptor activity capable of binding to mouse PBSF/SDF-1; cells expressing this polypeptide and human CD4 protein; and a method for screening an AIDS onset inhibitor, an HIV-1 infection inhibitor, etc. which comprises using the above-mentioned cells. Thus the invention provides a novel mouse CXC chemokine receptor gene which is useful in studies on a remedy for AIDS or the mode of action in the infection with HIV-1, a method for screening an HIV-1 infection inhibitor, etc.
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3.发明公开Rheumatoid arthritis remedy containing il-6 antagonist as active ingredient 失效风湿性关节炎关节炎IL-6拮抗剂Aktivsubstanz
公开(公告)号：EP2077120A2
公开(公告)日：2009-07-08
申请号：EP09000787.3
申请日：1995-06-07
IPC分类号： A61K39/395 , A61K38/20 , C12P21/08 , C12R1/46 , C07K16/24
CPC分类号： C07K16/244 , A61K38/00 , C07K16/248 , C07K16/2866
摘要： There is provided a synovial cell growth inhibitor, or a pharmaceutical composition for treatment of chronic rheumatoid arthritis based on the synovial cell growth inhibitor.
The pharmaceutical composition for treatment of chronic rheumatoid arthritis or synovial cell growth inhibitor contains an IL-6 antagonist, such as IL-6 antibody or IL-6R antibody, as an effective component.摘要翻译： 提供滑膜细胞生长抑制剂或基于滑膜细胞生长抑制剂治疗慢性类风湿性关节炎的药物组合物。 用于治疗慢性类风湿性关节炎或滑膜细胞生长抑制剂的药物组合物含有IL-6拮抗剂如IL-6抗体或IL-6R抗体作为有效成分。
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4.发明授权LEUKEMIC CELL GROWTH INHIBITOR CONTAINING ANTISENSE OLIGONUCLEOTIDE DERIVATIVE AGAINST WILMS' TUMOR GENE (WT1) 失效生长抑制剂AGAINST反义寡核苷酸衍生物的白血病细胞对抗的肾母细胞瘤基因含有
公开(公告)号：EP0841068B1
公开(公告)日：2006-07-12
申请号：EP96914430.2
申请日：1996-05-24
CPC分类号： A61K31/7088 , A61K38/00 , C12N15/1135 , C12N2310/311 , C12N2310/3125 , C12N2310/313 , C12N2310/314 , C12N2310/315
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公开(公告)号：EP0960935A4
公开(公告)日：2003-02-05
申请号：EP97954863
申请日：1997-02-07
申请人： SHIONOGI & CO , KISHIMOTO TADAMITSU
发明人： KISHIMOTO TADAMITSU , NAGASAWA TAKASHI , TACHIBANA KAZUNOBU , IIZASA HISASHI , YOSHIDA NOBUAKI , NAKAJIMA TOSHIHIRO , YOSHIE OSAMU
IPC分类号： A61K38/00 , C07K14/715 , C12N15/12 , A61K38/18 , A61K38/19 , C07K16/28 , C12N5/10 , C12P21/02 , C12P21/08 , G01N33/577
CPC分类号： C07K14/7158 , A61K38/00
摘要： A DNA encoding a polypeptide comprising the whole amino acid sequence described in SEQ. ID NO: 17 of the Sequence Listing or a part of the same or a polypeptide containing the above polypeptide which has a receptor activity capable of binding to mouse PBSF/SDF-1; a polypeptide encoded by this DNA and having a receptor activity capable of binding to mouse PBSF/SDF-1; cells expressing this polypeptide and human CD4 protein; and a method for screening an AIDS onset inhibitor, an HIV-1 infection inhibitor, etc. which comprises using the above-mentioned cells. Thus the invention provides a novel mouse CXC chemokine receptor gene which is useful in studies on a remedy for AIDS or the mode of action in the infection with HIV-1, a method for screening an HIV-1 infection inhibitor, etc.
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公开(公告)号：EP0257406B2
公开(公告)日：1998-08-12
申请号：EP87111409.6
申请日：1987-08-06
发明人： Kishimoto, Tadamitsu 5-31, Nakano 3 chome , Hirano, Toshio , Matsui, Hiroshi c/o Ajinomoto Co., Inc. , Takahara, Yoshiyuki c/o Ajinomoto Co., Inc. , Akiyama, Yukio c/o Ajinimoto Co., Inc. , Okano, Akira c/o Ajinomo Co., Inc.
CPC分类号： C07K14/54 , A61K38/00 , C07K14/5403 , C07K14/5412 , C07K14/55 , C07K2319/00 , C07K2319/02 , C07K2319/75 , Y10S514/885
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公开(公告)号：EP0676469A2
公开(公告)日：1995-10-11
申请号：EP95104670.5
申请日：1995-03-29
申请人： Kishimoto, Tadamitsu
CPC分类号： H01L23/5258 , A61K38/00 , C07K14/4705 , H01L2924/0002 , Y10S438/958 , H01L2924/00
摘要： Mammal transcription factor APRF, process for the preparation of it, DNAs encoding the said product, replication and expression vector comprising the said DNA, host cells transformed or tranfected with the said replication and expression vector, evaluating and screening method for searching an inhibitory agent on the function of APRF and an inhibitory agent against the function of the said APRF. The peptide of the present invention (APRF) may be useful for complement or suppression of the function of APRF, screening an inhibitory agent against the function of APRF. Inhibiting agent containing the said product as active ingredient of the present invention may be also useful for treatment of diseases related cytokine such as IL-6 i.e. inflammatory diseases.
摘要翻译： 哺乳动物转录因子APRF，其制备方法，编码所述产物的DNA，包含所述DNA的复制和表达载体，用所述复制和表达载体转化或转染的宿主细胞，用于搜索抑制剂的评估和筛选方法 APRF的功能和抗APRF功能的抑制剂。 本发明的肽（APRF）可用于补体或抑制APRF的功能，筛选抗APRF功能的抑制剂。 含有所述产物作为本发明活性成分的抑制剂也可用于治疗与疾病相关的细胞因子如IL-6即炎性疾病。
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公开(公告)号：EP0411946A2
公开(公告)日：1991-02-06
申请号：EP90308530.6
申请日：1990-08-02
申请人： Kishimoto, Tadamitsu
发明人： Kishimoto, Tadamitsu
CPC分类号： C07K14/705
摘要： Human gp130 protein having at least the following properties: (1) the protein has an affinity with a complex of IL-6 (interleukin-6) and an IL-6 receptor (interleukin-6 receptor); (2) the protein shows an apparent molecular weight of 130 kDa in SDS-polyacrylamide electrophoresis; and (3) the protein participates in the transmission of IL-6 signal; DNA coding for the protein, an expression plasmid containing the DNA; and a process for production of the protein using the expression plasmid.
摘要翻译： 具有以下性质的人gp130蛋白质：（1）该蛋白质与IL-6（白细胞介素-6）和IL-6受体（白细胞介素-6受体）的复合物具有亲和性; （2）蛋白质在SDS-聚丙烯酰胺电泳中的表观分子量为130kDa; 和（3）蛋白质参与IL-6信号的传递; 编码该蛋白质的DNA，含有该DNA的表达质粒; 以及使用表达质粒生产蛋白质的方法。
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公开(公告)号：EP0325474A3
公开(公告)日：1990-06-06
申请号：EP89300536.3
申请日：1989-01-20
申请人： Kishimoto, Tadamitsu
发明人： Kishimoto, Tadamitsu
IPC分类号： C07K14/00 , C12N15/00 , A61K39/395 , C12P21/02
CPC分类号： C07K14/7155 , A61K38/00
摘要： Isolated receptor proteins for human B cell stimulating factor-2 are capable of specifically binding to human B cell stimulating factor-2. DNA coding for the above-mentioned receptor protein, expression vectors containing the above-mentioned DNA, host organisms transformed with the above-mentioned expression vector, a process for production of the receptor protein comprising culturing the host organisms in a medium to produce the receptor protein and recovering the receptor protein from the culture, and an antibody reacting with the protein are also disclosed.
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10.发明公开Soluble recombinant Fc-Epsilon-receptor, the preparation and the use thereof 失效Auflösbarerrekombinanter Fc-Rezeptor，dessen Herstellung und Verwendung。
公开(公告)号：EP0321842A1
公开(公告)日：1989-06-28
申请号：EP88120878.9
申请日：1988-12-14
发明人： Kishimoto, Tadamitsu, Prof. Dr. , Suemura, Masaki, Dr. , Kikutani, Hitoshi, Dr. , Barsumian, Edward L., Dr. , Schneider, Franz-Josef, Dr. , Schwendenwein, Renate, Dr. , Sommergruber, Wolfgang, Dr. , Swetly, Peter, Dr.
CPC分类号： C12N15/85 , C07K14/5412 , C07K14/7056 , C07K2319/02
摘要： The present invention describes the expression of highly bioactive water-soluble Fc ε R in cells derived from multicellular organismns and the use thereof.
摘要翻译： 本发明描述了高生物活性水溶性FcεR在衍生自多细胞生物体的细胞中的表达及其用途。
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