公开(公告)号：EP1349841A2

公开(公告)日：2003-10-08

申请号：EP01999564.6

申请日：2001-12-05

申请人： SIGNAL PHARMACEUTICALS, INC.

发明人： KOIS, Adam ,  MACFARLANE, Karen, J. ,  SATOH, Yoshitaka ,  BHAGWAT, Shripad, S. ,  PARNES, Jason, S. ,  PALANKI, Moorthy, S., S. ,  ERDMAN, Paul, E.

IPC分类号： C07D239/42 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D403/12 ,  A61K31/505 ,  A61P29/00

CPC分类号： C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

摘要： Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: (A) wherein R1 and R6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to IKK inhibition. Thus, methods or treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

公开(公告)号：EP1349840A2

公开(公告)日：2003-10-08

申请号：EP01996103.6

申请日：2001-12-05

申请人： SIGNAL PHARMACEUTICALS, INC.

发明人： KOIS, Adam ,  MACFARLANE, Karen, J. ,  SATOH, Yoshitaka ,  BHAGWAT, Shripad, S. ,  PARNES, Jason, S. ,  PALANKI, Moorthy, S., S. ,  ERDMAN, Paul, E.

IPC分类号： C07D239/00

CPC分类号： C07D239/42 ,  A61K31/496 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D487/08 ,  C07D491/10 ,  A61K2300/00

摘要： Compounds having activity as inhibitors of the JNK pathway are disclosed. The compounds of this invention are anilinopyrimidine derivatives having the following structure: (I) wherein R1 through R6 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to inhibition of the JNK pathway. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

公开(公告)号：EP1515964A1

公开(公告)日：2005-03-23

申请号：EP03735581.5

申请日：2003-06-07

申请人： ALTANA Pharma AG ,  Signal Pharmaceuticals, Inc.

发明人： BAUDLER, Monika ,  BHAGWAT, Shripad, S. ,  ERDMAN, Paul, E. ,  GANTNER, Florian ,  PALANKI, Moorthy S., S. ,  SCHUDT, Christian ,  STADLWIESER, Josef ,  ZAPF, James

IPC分类号： C07D401/14 ,  C07D409/14 ,  A61K31/506 ,  A61P11/00 ,  C07D405/14

CPC分类号： C07D409/14 ,  C07D401/14 ,  C07D405/14 ,  C07D417/14

摘要： The invention relates to substituted diaminopyrimidine compounds, which are effective therapeutic compounds for treating diseases and disorders associated with those commonly treated by Protein Kinase C theta (PKCtheta) inhibitors.

摘要翻译： 本发明涉及取代的二氨基嘧啶化合物，其是治疗与通常由蛋白激酶Cθ（PKCθ）抑制剂治疗的疾病和病症有关的疾病和病症的有效治疗性化合物。