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    Leukotriene antagonists
    3.
    发明公开
    Leukotriene antagonists 失效
    Leukotrienantagonisten。

    公开(公告)号：EP0403249A1

    公开(公告)日：1990-12-19

    申请号：EP90306438.4

    申请日：1990-06-13

    申请人： SMITHKLINE BEECHAM CORPORATION

    发明人： Frazee, James Simpson ,  Gleason, John Gerald ,  Hall, Ralph Floyd

    IPC分类号： C07C317/46 ,  C07C323/62 ,  C07C323/56 ,  C07D311/24 ,  A61K31/19 ,  A61K31/215 ,  A61K31/35

    CPC分类号： C07D311/24 ,  C07C317/46 ,  C07C323/56 ,  C07C323/62

    摘要： Compounds represented by the following structural formula (I):
    wherein q is O or 2;
    R₁ is (L) a -(CH₂) b -(T) c -M
    a is 0 or 1;
    b is 3 to 14;
    c is 0 or 1;
    L and T are independently oxygen or CH₂;
    M is C₁₋₄ alkyl, ethynyl, trifluoromethyl, isopropenyl, furanyl, thienyl, cyclohexyl or phenyl optionally monosubstituted with Br, Cl, CF₃, alkoxy, alkyl, methylthio, or trifluoromethylthio;
    Y is (CHX)(CH₂) p -Z wherein
    Z is COR₃, or tetrazolyl; in which
    R₃ is OH, NH₂, aryloxy, or C₁₋₆ alkoxy;
    p is 0, 1 or 2;
    X is OH, or alkoxy;
    R is -(CH₂) p -W;
    d is 0 to 6;
    W is phenyl substituted with B, C, or D;
    B is-(CH₂) p -V wherein p is 0 to 6 and V is COR₃, SO₃H, SO₂H, SO₂NH₂, COCH₂OH, CHOHCH₂OH, or tetrazolyl, with R₃ as defined above;
    C and D are independently selected from H, OH, F, Cl, Br, CF₃, alkyl, alkoxy, methylthio, trifluoromethylthio, NO₂, NH₂, NHalkyl, or CalkylCO-; or
    pharmaceutically acceptable salts thereof, can be used in the preparation of a medicament for the treatment of asthma.

    摘要翻译： 由以下结构式（I）表示的化合物：其中q为O或2; R 1是（L）a-（CH 2）b - （T）c-M a是0或1; b为3〜14; c为0或1; L和T独立地是氧或CH 2; M是C 1-6烷基，乙炔基，三氟甲基，异丙烯基，呋喃基，噻吩基，环己基或任选被Br，Cl，CF 3，烷氧基，烷基，甲硫基或三氟甲硫基单取代的苯基; Y是（CHX）（CH2）p -Z，其中Z是COR3或四唑基; 其中R 3是OH，NH 2，芳氧基或C 1-6烷氧基; p为0,1或2; X是OH或烷氧基; R是 - （CH 2）p -W; d为0〜6; W是被B，C或D取代的苯基; B为 - （CH 2）p -V，其中p为0至6，V为COR 3，SO 3 H，SO 2 H，SO 2 NH 2，COCH 2 OH，CHOHCH 2 OH或四唑基， C和D独立地选自H，OH，F，Cl，Br，CF 3，烷基，烷氧基，甲硫基，三氟甲硫基，NO 2，NH 2，NH烷基或C烷基CO-; 或其药学上可接受的盐可用于制备用于治疗哮喘的药物。