公开(公告)号：EP1095020A1

公开(公告)日：2001-05-02

申请号：EP99929395.4

申请日：1999-07-05

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

发明人： CHABRIER DE LASSAUNIERE, Pierre-Etienne ,  AUVIN, Serge ,  HARNETT, Jerry ,  PONS, Dominique ,  ULIBARRI, Gérard ,  BIGG, Dennis

IPC分类号： C07D213/73 ,  C07D405/12 ,  A61K31/44 ,  A61K31/495 ,  C07D401/04 ,  C07C233/44 ,  C07C271/22

CPC分类号： C07K14/70575 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0325 ,  A01K2267/0368 ,  A01K2267/0381 ,  A61K2039/505 ,  C07D213/73 ,  C07D401/04 ,  C07D405/12 ,  C07K16/2875 ,  C07K16/2878 ,  C12N15/8509

摘要： The invention concerns novel 2-aminopyridine derivatives having an activity inhibiting NO-synthase enzymes producing nitrogen monoxide NO and/or trapping reactive forms of oxygen, the methods for preparing them, pharmaceutical compositions containing them and their therapeutic uses, particularly their use as NO-synthase inhibitors and for trapping reactive forms of oxygen whether selectively or not.

公开(公告)号：EP1115719A2

公开(公告)日：2001-07-18

申请号：EP99943024.2

申请日：1999-09-22

申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

发明人： AUVIN, Serge ,  CHABRIER DE LASSAUNIERE, Pierre-Etienne ,  HARNETT, Jeremiah ,  PONS, Dominique ,  ULIBARRI, Gérard

IPC分类号： C07D333/36 ,  A61K31/38 ,  A61K31/495 ,  C07D409/12 ,  C07D333/38

CPC分类号： C07D409/12 ,  C07C217/84 ,  C07D333/20 ,  C07D333/36 ,  C07D333/38 ,  C07D409/14 ,  C07D417/12 ,  C07D473/08

摘要： The invention concerns novel amidine derivatives, and in particular the following compounds: 2-hydroxy -5-methoxy -N-{2-[4-[(2 -thienyl(imino) methyl) amino]phenyl]ethyl} -benzamide; 2.5-dihydroxy -N-{2-[4[2 -thienyl(imino)methyl) amino]phenyl]ethyl} -benzamide ; and their use as medicines and pharmaceutical compositions containing them.