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1.发明公开ANALOGUES OPTIQUEMENT PURS DE LA CAMPTOTHECINE, INTERMEDIAIRE DE SYNTHESE OPTIQUEMENT PUR ET SON PROCEDE DE PREPARATION 有权光学PURE CAMPTOTHECINANALOGE，光学纯合成中间体和工艺及其
公开(公告)号：EP1007527A1
公开(公告)日：2000-06-14
申请号：EP98941567.4
申请日：1998-08-07
发明人： CAZAUX, Jean-Bernard , LAVERGNE, Olivier , LE BRETON, Christine , MANGINOT, Eric,Lotissement "Les Sabines" , BIGG, Dennis
IPC分类号： C07D491/22 , C07D491/04 , A61K31/435
CPC分类号： C07D491/04
摘要： The invention concerns novel camptothecin analogues and in particular products corresponding to the following formulae: (+)-5-ethyl-9, 10-difluoro-5-hydroxy-4, 5,13,15-tetrahydro-1H, 3H-oxepino[3',4':6, 7]indolizino[1,2-b] quinoline-3,15-dione; (+)-1-[9-chloro-5- ethyl-5-hydroxy-10-methyl-3, 15-dioxo-4,5,13, 15-tetrahydro-1H,3H-oxepinol[3' ,4':6,7]indolizino [1,2-b]quinoline-12-ylmethyl] -4-methyl-hexahydropyridinium chloride; their application as medicine, pharmaceutical compositions containing them and their use for producing antitumoral, antiviral or antiparasitic medicines. The invention also concerns a novel synthesis intermediate of said products and a method for preparing said intermediate.
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2.发明公开
公开(公告)号：EP1095020A1
公开(公告)日：2001-05-02
申请号：EP99929395.4
申请日：1999-07-05
发明人： CHABRIER DE LASSAUNIERE, Pierre-Etienne , AUVIN, Serge , HARNETT, Jerry , PONS, Dominique , ULIBARRI, Gérard , BIGG, Dennis
IPC分类号： C07D213/73 , C07D405/12 , A61K31/44 , A61K31/495 , C07D401/04 , C07C233/44 , C07C271/22
CPC分类号： C07K14/70575 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0368 , A01K2267/0381 , A61K2039/505 , C07D213/73 , C07D401/04 , C07D405/12 , C07K16/2875 , C07K16/2878 , C12N15/8509
摘要： The invention concerns novel 2-aminopyridine derivatives having an activity inhibiting NO-synthase enzymes producing nitrogen monoxide NO and/or trapping reactive forms of oxygen, the methods for preparing them, pharmaceutical compositions containing them and their therapeutic uses, particularly their use as NO-synthase inhibitors and for trapping reactive forms of oxygen whether selectively or not.
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3.发明公开
公开(公告)号：EP0991654A1
公开(公告)日：2000-04-12
申请号：EP98932205.2
申请日：1998-06-15
IPC分类号： C07D521/00 , A61K31/38 , A61K31/425 , A61K31/445 , A61K31/415 , C07D417/12 , C07D277/04 , C07D409/12 , C07D211/70 , C07D333/70 , C07D277/06 , C07D307/68 , C07D233/78 , C07D277/14 , C07D207/16
CPC分类号： C07D417/12 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12
摘要： The invention concerns novel 2-(iminomethyl)amino-phenyl derivatives, their preparation, their application as medicines and compositions containing them.
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公开(公告)号：EP1305294A2
公开(公告)日：2003-05-02
申请号：EP01957342.7
申请日：2001-07-31
发明人： THURIEAU, Christophe, Alain , POITOUT, Lydie, Francine , GALCERA, Marie-Odile , GORDON, Thomas, D. , MORGAN, Barry, A. , MOINET, Christophe, Philippe , BIGG, Dennis
IPC分类号： C07D233/54 , C07D403/06 , A61P5/02
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D491/10 , C07D497/04
摘要： The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.
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5.发明公开UTILISATION DE DIAZEPINES POUR LA PREPARATION DE MEDICAMENTS DESTINES A TRAITER LES ETATS PATHOLOGIQUES OU LES MALADIES DANS LESQUELS UN DES RECEPTEURS DE LA SOMATOSTATINE EST IMPLIQUE 审中-公开二氮杂的用途是用于药物的病理状况或疾病的治疗方法哪一种somatostatins受体所涉及的生产
公开(公告)号：EP1087978A1
公开(公告)日：2001-04-04
申请号：EP99925093.9
申请日：1999-06-15
IPC分类号： C07D495/22 , A61K31/55
CPC分类号： C07D495/22
摘要： The invention concerns the use of pyrido-thieno-triazolo-diazepins for preparing a medicine for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors. The invention also concerns novel pyrido-thieno-triazolo-diazepins and therapeutic compositions containing them.
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6.发明公开NOUVEAUX ANALOGUES TETRACYCLIQUES DE CAMPTOTHECINES, LEURS PROCEDES DE PREPARATION, LEUR APPLICATION COMME MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES CONTENANT 有权四环CAMPOTHECINEANALOGUE，PROCESS FOR他们对使用药物和装有药剂
公开(公告)号：EP1042323A1
公开(公告)日：2000-10-11
申请号：EP98962480.4
申请日：1998-12-16
IPC分类号： C07D471/14 , A61K31/44 , C07D213/64
CPC分类号： C07D213/64 , C07D471/14
摘要： The invention concerns novel camptothecin tetracyclic analogues of formula (I), preparation methods, applications as medicines and pharmaceutical compositions containing them. Said analogues, among which figures in particular 3-hydroxy-3-(4-oxo-4,6-dihydroindolizino [1,2-b] quinoline-2-yl)pentanoic acid, have a powerful biological activity for inhibiting topoisomerase I and/or topoisomerase II.
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7.发明公开
公开(公告)号：EP1115720A2
公开(公告)日：2001-07-18
申请号：EP99943025.9
申请日：1999-09-22
发明人： BIGG, Dennis , CHABRIER DE LASSAUNIERE, Pierre-Etienne , AUVIN, Serge , HARNETT, Jeremiah , ULIBARRI, Gérard
IPC分类号： C07D333/38 , A61K31/38 , C07D409/12 , C07D417/12
CPC分类号： C07D333/38
摘要： The invention concerns novel N-(iminomethyl)amine derivatives comprising in their skeleton the aminophenylamine, oxodiphenylamine, carbazole, phenazine, phenoxazine or oxodiphenyl motif, their use as medicines and pharmaceutical compositions containing them. The invention concerns in particular the following compounds: -4-{[2-thienyl (imino) methyl]amino}-N- [2-(phenylamino) phenyl]- benzenebutanamide; -4-{[2- thienyl (imino) methyl]amino}- N-[4-(phenylamino) phenyl]- benzenebutanamide; -N'-[4- (10H- phenothiazin - 2-yloxy) phenyl]- 2-thiophenecarboximidamide; -4-(4-{[amino (2-thienyl) methylidene] amino}phenyl) -N-(10H- phenothiazin- 3-ylH) butanamide; -3-[(3-{[amino (2-thienyl) methylidene] amino}-benzyl) amino]-N- (4-anilinophenyl) propanamide; -N'-(4-{2- [(10H-phenothiazin- 3-ylmethyl) amino] ethyl}phenyl- 2-thiophene carboximidamide.
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8.发明公开UTILISATION D'YLURES DE PHOSPHORE EN TANT QUE BASES FORTES FAIBLEMENT NUCLEOPHILES 失效磷叶立德，生产和使用过弱亲核STARK碱性化合物
公开(公告)号：EP0986585A1
公开(公告)日：2000-03-22
申请号：EP98925783.7
申请日：1998-05-26
申请人： SOCIETE DE CONSEILS DE RECHERCHESET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) , CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE
发明人： BERTRAND, Guy , BIGG, Dennis , CAZAUX, Jean-Bernard , GOUMRI, StéphanieBâtiment A - Appartement A 36 , GUERRET, Olivier
CPC分类号： C07D207/267 , C07D227/087 , C07D243/16 , C07F9/5352 , C07K1/082 , C08F8/40
摘要： The invention concerns the use of ylides of phosphorus of general formula (I') in which R'1, R'2, R'3, R'4, R'5 represent different variable groups, as a slightly nucleophilic base. The invention also concerns novel ylides of general formula (I) in which R1, R2 and R3 and R4 represent different variable groups and R5 represents a polymeric support.
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